Irinotecan-impurities | Pharmaffiliates

irinotecan

Irinotecan main use is in colon cancer, in particular, in combination with other chemotherapy agents. This includes the regimen FOLFIRI, which consists of infusional 5-fluorouracil, leucovorin, and irinotecan. It is sold under the brand name Camptosar. Reference standards of Irinotecan API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

stdClass Object
(
    [pname] => 4-Ethyl-4-hydroxy-11-isopropyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate;
    [catalogue_number] => PA 09 16570
    [category_ids] => ,69,76,75,78,70,82,
    [chemical_name] => 
    [weight] => 600.7
    [form] => C34H40N4O6
    [cas] => NA
    [pslug] => 4-ethyl-4-hydroxy-11-isopropyl-3-14-dioxo-3-4-12-14-tetrahydro-1h-pyrano-3-4-6-7-indolizino-1-2-b-quinolin-9-yl-1-4-bipiperidine-1-carboxylate-pa0916570
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PA 09 16570

4-Ethyl-4-hydroxy-11-isopropyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate;


  • Catalogue No.:PA 09 16570

  • CAS :

    NA

  • Molecular Formula : C34H40N4O6

  • Molecular Weight : 600.7

stdClass Object
(
    [pname] => rac-Desmethyl Irinotecan Hydrochloride
    [catalogue_number] => PA 09 16580
    [category_ids] => ,82,78,76,75,70,69,
    [chemical_name] => 
    [weight] => 609.11
    [form] => C32H37ClN4O6
    [cas] => NA
    [pslug] => rac-desmethyl-irinotecan-hydrochloride-pa0916580
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PA 09 16580

rac-Desmethyl Irinotecan Hydrochloride


  • Catalogue No.:PA 09 16580

  • CAS :

    NA

  • Molecular Formula : C32H37ClN4O6

  • Molecular Weight : 609.11

stdClass Object
(
    [pname] => 10-O-Acetyl SN-38-d3
    [catalogue_number] => PA STI 003450
    [category_ids] => ,69,76,78,70,82,98,
    [chemical_name] => 
    [weight] => 437.46
    [form] => C24H19D3N2O6
    [cas] => NA
    [pslug] => 10-o-acetyl-sn-38-d3-pasti003450
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PA STI 003450

10-O-Acetyl SN-38-d3


  • Catalogue No.:PA STI 003450

  • CAS :

    NA

  • Molecular Formula : C24H19D3N2O6

  • Molecular Weight : 437.46

stdClass Object
(
    [pname] => 7-Ethyl-10-(4-N-aminopentanoic acid)-1-piperidino)carbonyloxycamptothecin-d3
    [catalogue_number] => PA STI 038750
    [category_ids] => ,76,75,78,70,82,98,
    [chemical_name] => 
    [weight] => 621.70
    [form] => C33H35D3N4O8
    [cas] => 1217816-76-6
    [pslug] => 1217816-76-6-7-ethyl-10-4-n-aminopentanoic-acid-1-piperidino-carbonyloxycamptothecin-d3-pasti038750
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PA STI 038750

7-Ethyl-10-(4-N-aminopentanoic acid)-1-piperidino)carbonyloxycamptothecin-d3


  • Catalogue No.:PA STI 038750

  • CAS :

    1217816-76-6

  • Molecular Formula : C33H35D3N4O8

  • Molecular Weight : 621.70

stdClass Object
(
    [pname] => 7-Ethyl-10-(4-amino-1-piperidino)carbonyloxycamptothecin-d3
    [catalogue_number] => PA STI 038760
    [category_ids] => ,76,75,78,70,82,98,
    [chemical_name] => 
    [weight] => 521.58
    [form] => C28H27D3N4O6
    [cas] =>  1217625-98-3
    [pslug] => 1217625-98-3-7-ethyl-10-4-amino-1-piperidino-carbonyloxycamptothecin-d3-pasti038760
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PA STI 038760

7-Ethyl-10-(4-amino-1-piperidino)carbonyloxycamptothecin-d3


  • Catalogue No.:PA STI 038760

  • CAS :

    1217625-98-3

  • Molecular Formula : C28H27D3N4O6

  • Molecular Weight : 521.58

stdClass Object
(
    [pname] => 1-(2-Amino-5-hydroxyphenyl)propan-1-one
    [catalogue_number] => PA 09 0151000
    [category_ids] => ,75,76,70,78,82,
    [chemical_name] => 
    [weight] => 165.19
    [form] => C9H11NO2
    [cas] => 35364-15-9
    [pslug] => 35364-15-9-1-2-amino-5-hydroxyphenyl-propan-1-one-pa090151000
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PA 09 0151000

1-(2-Amino-5-hydroxyphenyl)propan-1-one


  • Catalogue No.:PA 09 0151000

  • CAS :

    35364-15-9

  • Molecular Formula : C9H11NO2

  • Molecular Weight : 165.19

stdClass Object
(
    [pname] => 4-Piperidinopiperidine-1-carbonyl Chloride
    [catalogue_number] => PA 09 0161000
    [category_ids] => ,78,75,76,82,
    [chemical_name] => 
    [weight] => 230.74
    [form] => C11H19ClN2O
    [cas] => 103816-19-9
    [pslug] => 103816-19-9-4-piperidinopiperidine-1-carbonyl-chloride-pa090161000
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PA 09 0161000

4-Piperidinopiperidine-1-carbonyl Chloride


  • Catalogue No.:PA 09 0161000

  • CAS :

    103816-19-9

  • Molecular Formula : C11H19ClN2O

  • Molecular Weight : 230.74

stdClass Object
(
    [pname] => Irinotecan-d10 Hydrochloride (Major)
    [catalogue_number] => PA STI 088709
    [category_ids] => ,98,69,123,81,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 633.21
    [form] => C33H29D10ClN4O6
    [cas] => 718612-62-5
    [pslug] => 718612-62-5-irinotecan-d10-hydrochloride-major-pasti088709
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PA STI 088709

Irinotecan-d10 Hydrochloride (Major)


  • Catalogue No.:PA STI 088709

  • CAS :

    718612-62-5

  • Molecular Formula : C33H29D10ClN4O6

  • Molecular Weight : 633.21

stdClass Object
(
    [pname] => (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 2'-ethoxy-[1,4'-bipiperidine]-1'-carboxylate
    [catalogue_number] => PA 09 0151001
    [category_ids] => ,70,75,76,78,82,
    [chemical_name] => 
    [weight] => 630.74
    [form] => C35H42N4O7
    [cas] => NA
    [pslug] => S-4-11-diethyl-4-hydroxy-3-14-dioxo-3-4-12-14-tetrahydro-1h-pyrano-3-4-6-7-indolizino-1-2-b-quinolin-9-yl-2-ethoxy-1-4-bipiperidine-1-carboxylate-pa090151001
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PA 09 0151001

(S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 2'-ethoxy-[1,4'-bipiperidine]-1'-carboxylate


  • Catalogue No.:PA 09 0151001

  • CAS :

    NA

  • Molecular Formula : C35H42N4O7

  • Molecular Weight : 630.74

stdClass Object
(
    [pname] => (4S)-4,11-Diethyl-4,9,12-trihydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione
    [catalogue_number] => PA 09 0151002
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 408.41
    [form] => C22H20N2O6
    [cas] => 200619-21-2
    [pslug] => 200619-21-2-4s-4-11-diethyl-4-9-12-trihydroxy-1-12-dihydro-14h-pyrano-3-4-6-7-indolizino-1-2-b-quinoline-3-14-4h-dione-pa090151002
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PA 09 0151002

(4S)-4,11-Diethyl-4,9,12-trihydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione


  • Catalogue No.:PA 09 0151002

  • CAS :

    200619-21-2

  • Molecular Formula : C22H20N2O6

  • Molecular Weight : 408.41

stdClass Object
(
    [pname] => 2'-Ethoxy-[1,4'-bipiperidine]-1'-carbonyl Chloride
    [catalogue_number] => PA 09 0151003
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 274.79
    [form] => C13H23ClN2O2
    [cas] => NA
    [pslug] => 2-ethoxy-1-4-bipiperidine-1-carbonyl-chloride-pa090151003
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PA 09 0151003

2'-Ethoxy-[1,4'-bipiperidine]-1'-carbonyl Chloride


  • Catalogue No.:PA 09 0151003

  • CAS :

    NA

  • Molecular Formula : C13H23ClN2O2

  • Molecular Weight : 274.79

stdClass Object
(
    [pname] => 2'-hydroxy-[1,4'-bipiperidine]-1'-carbonyl chloride
    [catalogue_number] => PA 09 0151004
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 246.74
    [form] => C11H19ClN2O2
    [cas] => NA
    [pslug] => 2-hydroxy-1-4-bipiperidine-1-carbonyl-chloride-pa090151004
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PA 09 0151004

2'-hydroxy-[1,4'-bipiperidine]-1'-carbonyl chloride


  • Catalogue No.:PA 09 0151004

  • CAS :

    NA

  • Molecular Formula : C11H19ClN2O2

  • Molecular Weight : 246.74

stdClass Object
(
    [pname] => SN-38 Tri-O-acetyl-β-D-glucuronic acid methyl ester
    [catalogue_number] => PA 09 0151005
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 708.67
    [form] => C35H36N2O14
    [cas] => 121098-77-9
    [pslug] => 121098-77-9-sn-38-tri-o-acetyl-beta-d-glucuronic-acid-methyl-ester-pa090151005
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PA 09 0151005

SN-38 Tri-O-acetyl-β-D-glucuronic acid methyl ester


  • Catalogue No.:PA 09 0151005

  • CAS :

    121098-77-9

  • Molecular Formula : C35H36N2O14

  • Molecular Weight : 708.67

stdClass Object
(
    [pname] => (S)-12-Ethyl-8-(hydroxymethyl)-7-(1-hydroxypropyl)-9-oxo-9,11-dihydroindolizino[1,2-b]quinolin-2-yl [1,4'-bipiperidine]-1'-carboxylate
    [catalogue_number] => PA 09 0151006
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 560.7
    [form] => C32H40N4O5
    [cas] => 185304-41-0
    [pslug] => 185304-41-0-s-12-ethyl-8-hydroxymethyl-7-1-hydroxypropyl-9-oxo-9-11-dihydroindolizino-1-2-b-quinolin-2-yl-1-4-bipiperidine-1-carboxylate-pa090151006
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PA 09 0151006

(S)-12-Ethyl-8-(hydroxymethyl)-7-(1-hydroxypropyl)-9-oxo-9,11-dihydroindolizino[1,2-b]quinolin-2-yl [1,4'-bipiperidine]-1'-carboxylate


  • Catalogue No.:PA 09 0151006

  • CAS :

    185304-41-0

  • Molecular Formula : C32H40N4O5

  • Molecular Weight : 560.7

stdClass Object
(
    [pname] => Irinotecan - Impurity G (Hydrochloride Salt)
    [catalogue_number] => PA 09 0150070
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 456.92
    [form] => C24H25ClN2O5
    [cas] => NA
    [pslug] => irinotecan-impurity-g-hydrochloride-salt-pa090150070
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PA 09 0150070

Irinotecan - Impurity G (Hydrochloride Salt)


  • Catalogue No.:PA 09 0150070

  • CAS :

    NA

  • Molecular Formula : C24H25ClN2O5

  • Molecular Weight : 456.92

stdClass Object
(
    [pname] => Sodium (S)-2-(12-ethyl-8-(hydroxymethyl)-2-oxido-9-oxo-9,11-dihydroindolizino[1,2-b]quinolin-7-yl)-2-hydroxybutanoate
    [catalogue_number] => PA 09 0151007
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 454.39
    [form] => C22H20N2Na2O6
    [cas] => NA
    [pslug] => sodium-s-2-12-ethyl-8-hydroxymethyl-2-oxido-9-oxo-9-11-dihydroindolizino-1-2-b-quinolin-7-yl-2-hydroxybutanoate-pa090151007
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PA 09 0151007

Sodium (S)-2-(12-ethyl-8-(hydroxymethyl)-2-oxido-9-oxo-9,11-dihydroindolizino[1,2-b]quinolin-7-yl)-2-hydroxybutanoate


  • Catalogue No.:PA 09 0151007

  • CAS :

    NA

  • Molecular Formula : C22H20N2Na2O6

  • Molecular Weight : 454.39