1-(2-Amino-5-hydroxyphenyl)propan-1-one

In House Impurity

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Catalogue number:	PA 09 0151000
Chemical name:	1-(2-Amino-5-hydroxyphenyl)propan-1-one
CAS Number:	35364-15-9
Category:	impurities,metabolites,intermediates,pharmaceutical standards,Fine Chemicals
Synonyms:	2'-Amino-5'-hydroxypropiophenone; Irinotecan - In house impurity
Molecular form:	C₉H₁₁NO₂
Appearance:	Yellow to Beige Solid
Mol. Weight:	165.19
Storage:	2-8°C Refrigerator, Under inert atmosphere
Shipping Conditions:	Ambient
Applications:	1-(2-Amino-5-hydroxyphenyl)propan-1-one is a useful synthetic intermediate. It is used in the asymmetrical synthesis of (S)-4-ethyl-6,7,8,10- tetrahydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione, a key intermediate for synthesis of irinotecan and other camptothecin analogs. It is also used in the synthesis of E-ring-modified (RS)-camptothecin analogs as antitumor agents.