A multikinase inhibitor, Regorafenib is used in the treatment of metastatic colorectal cancer and advanced gastrointestinal stromal tumors. Shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition.Reference standards of Regorafenib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Regorafenib
Catalogue No.:PA 18 49000
CAS :
Molecular Formula : C21H15ClF4N4O3
Molecular Weight : 482.82
Regorafenib N-Oxide
Catalogue No.:PA 18 49510
Molecular Formula : C21H15ClF4N4O4
Molecular Weight : 498.81
4-(4-Amino-3-fluorophenoxy)-N-(2-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)picolinamide
Catalogue No.:PA 18 49520
Molecular Formula : C25H19F2N5O4
Molecular Weight : 491.45
Hydroxyregorafenib
Catalogue No.:PA 18 49530
4-Dechloro-2-chloro-Regorafenib
Catalogue No.:PA 18 49540
4-[3-Fluoro-4-[[2-(methylcarbamoyl)pyridin-4-yl]amino]phenoxy]-N-methylpyridine-2-carboxamide
Catalogue No.:PA 18 49550
Molecular Formula : C20H18FN5O3
Molecular Weight : 395.39
4,4'-(((Carbonylbis(azanediyl))bis(3-fluoro-4,1-phenylene))bis(oxy))bis(N-methylpicolinamide)
Catalogue No.:PA 18 49560
Molecular Formula : C27H22F2N6O5
Molecular Weight : 548.5
4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinic Acid
Catalogue No.:PA 18 49570
Molecular Formula : C20H12ClF4N3O4
Molecular Weight : 469.77
N-Desmethyl Regorafenib
Catalogue No.:PA 18 49580
Molecular Formula : C20H13ClF4N4O3
Molecular Weight : 468.79
4-Amino-3-fluorophenol
Catalogue No.:PA 18 49590
Molecular Formula : C6H6FNO
Molecular Weight : 127.12
(4-Chloro-3-(trifluoromethyl)phenyl)carbamic Acid
Catalogue No.:PA 18 49600
Molecular Formula : C8H5ClF3NO2
Molecular Weight : 239.58
(2-Fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)carbamic Acid
Catalogue No.:PA 18 49610
Molecular Formula : C14H12FN3O4
Molecular Weight : 305.26
Regorafenib Tablets EP Impurity FP-A
Catalogue No.:PA 18 49630
Molecular Formula : C16H16FN3O4
Molecular Weight : 333.31
4-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide
Catalogue No.:PA 18 49010
Molecular Formula : C13H12FN3O2
Molecular Weight : 261.25
4-[4-[[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl]amino]-3-[4-[[[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl]amino]-3-fluorophenoxy]phenoxy]-N-methylpyridine-2-carboxamide
Catalogue No.:PA 18 0490050
Molecular Formula : C35H23Cl2F7N6O5
Molecular Weight : 811.49
N-Desmethyl Regorafenib N-Oxide (M5 Metabolite)
Catalogue No.:PA 18 0491000
Molecular Formula : C20H13ClF4N4O4
Molecular Weight : 484.79
4-(3-Fluoro-4-(3-(3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide
Catalogue No.:PA 18 0491001
Molecular Formula : C21H16F4N4O3
Molecular Weight : 448.38
4-(4-acetamido-3-fluorophenoxy)-N-methylpicolinamide
Catalogue No.:PA 18 0491002
Molecular Formula : C15H14FN3O3
Molecular Weight : 303.29
Regorafenib D3
Catalogue No.:PA STI 089099
Molecular Formula : C21H12D3ClF4N4O3
Molecular Weight : 485.84
Regorafenib 13CD3
Catalogue No.:PA STI 089168
Molecular Formula : C2013CH12D3ClF4N4O3
Molecular Weight : 486.83
Regorafenib 13CD3 N-Oxide
Catalogue No.:PA STI 089169
Molecular Formula : C2013CH12D3ClF4N4O4
Molecular Weight : 502.83
Regorafenib Dipyrimidine Impurity
Catalogue No.:PA 18 0491003
Molecular Formula : C20H17FN4O3
Molecular Weight : 380.38
4,4'-((2-Fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)azanediyl)bis(N-methylpicolinamide)
Catalogue No.:PA 18 0491004
Molecular Formula : C27H24FN7O4
Molecular Weight : 529.53
Regorafenib N-Oxide D3
Catalogue No.:PA STI 089607
Molecular Formula : C21H12D3ClF4N4O4
Molecular Weight : 501.84
N-Desmethyl Regorafenib N-Oxide-d3
Catalogue No.:PA STI 089608
Molecular Formula : C20H10D3ClF4N4O4
Molecular Weight : 487.81
4-Chloro-N-methyl-6-(methylamino)picolinamide
Catalogue No.:PA 18 0491005
Molecular Formula : C8H10ClN3O
Molecular Weight : 199.64
1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-ethylurea
Catalogue No.:PA 18 0491006
Molecular Formula : C10H10ClF3N2O
Molecular Weight : 266.65
4-(4-Amino-3-(4-amino-3-fluorophenoxy)phenoxy)-N-methylpicolinamide
Catalogue No.:PA 18 0491007
Molecular Formula : C19H17FN4O3
Molecular Weight : 368.37
4-(4-Amino-3-fluorophenoxy)picolinic Acid
Catalogue No.:PA 18 0491008
Molecular Formula : C12H9FN2O3
Molecular Weight : 248.21
Methyl 4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylate
Catalogue No.:PA 18 0491009
Molecular Formula : C13H11FN2O3
Molecular Weight : 262.24
Ethyl 4-(4-amino-3-fluorophenoxy)picolinate
Catalogue No.:PA 18 0491010
Molecular Formula : C14H13FN2O3
Molecular Weight : 276.27
1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-hydroxyphenyl)urea
Catalogue No.:PA 18 0491011
Molecular Formula : C14H9ClF4N2O2
Molecular Weight : 348.68
3-(4-Chloro-3-(trifluoromethyl)phenyl)-1-((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)-1-(2-fluoro-4-hydroxyphenyl)urea
Catalogue No.:PA 18 0491012
Molecular Formula : C22H12Cl2F7N3O3
Molecular Weight : 570.24
4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenyl (4-chloro-3-(trifluoromethyl)phenyl)carbamate
Catalogue No.:PA 18 0491013
1,3-Bis(4-chloro-3-(trifluoromethyl)phenyl)-1-((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)urea
Catalogue No.:PA 18 0491014
Molecular Formula : C23H11Cl3F9N3O2
Molecular Weight : 638.7
4,5,6-trichloro-N-methylpicolinamide
Catalogue No.:PA 18 0491015
Molecular Formula : C7H5Cl3N2O
Molecular Weight : 239.48
1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-6-hydroxyphenyl)urea
Catalogue No.:PA 18 0491016
4-Hydroxy-N-methylpicolinamide
Catalogue No.:PA 18 0491017
Molecular Formula : C7H8N2O2
Molecular Weight : 152.15
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