methotrexate

Heterocycles - An antimetabolite of the antifolate type, Methotrexate is an chemotherapy drug and used for treating autoimmune diseases like psoriasis, rheumatoid arthritis. It causes life threatening side effects. Reference standards of Methotrexate API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

stdClass Object
(
    [pname] => Methotrexate
    [catalogue_number] => PA 13 28000
    [category_ids] => ,85,83,82,80,78,71,70,69,170,
    [chemical_name] => 
    [weight] => 454.44
    [form] => C20H22N8O5
    [cas] => 59-05-2
    [pslug] => 59-05-2-methotrexate-api-pa1328000
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PA 13 28000
PA 13 28000

Methotrexate


  • Catalogue No.:PA 13 28000

  • CAS :

    59-05-2

  • Molecular Formula : C20H22N8O5

  • Molecular Weight : 454.44

stdClass Object
(
    [pname] => Methotrexate - Impurity B (Freebase)
    [catalogue_number] => PA 13 28020
    [category_ids] => ,70,71,78,80,81,82,97,
    [chemical_name] => 
    [weight] => 440.41
    [form] => C19H20N8O5
    [cas] => 54-62-6
    [pslug] => 54-62-6-methotrexate-impurity-b-freebase-pa1328020
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PA 13 28020
PA 13 28020

Methotrexate - Impurity B (Freebase)


  • Catalogue No.:PA 13 28020

  • CAS :

    54-62-6

  • Molecular Formula : C19H20N8O5

  • Molecular Weight : 440.41

stdClass Object
(
    [pname] => Methotrexate - Impurity C
    [catalogue_number] => PA 13 28030
    [category_ids] => ,70,71,78,80,82,
    [chemical_name] => 
    [weight] => 455.42
    [form] => C20H21N7O6
    [cas] => 2410-93-7
    [pslug] => 2410-93-7-methotrexate-impurity-c-freebase-pa1328030
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PA 13 28030
PA 13 28030

Methotrexate - Impurity C


  • Catalogue No.:PA 13 28030

  • CAS :

    2410-93-7

  • Molecular Formula : C20H21N7O6

  • Molecular Weight : 455.42

stdClass Object
(
    [pname] => Methotrexate - Impurity D
    [catalogue_number] => PA 13 28040
    [category_ids] => ,80,71,78,70,82,
    [chemical_name] => 
    [weight] => 326.31
    [form] =>  C15H14N6O3
    [cas] => 5623-18-7
    [pslug] => 5623-18-7-methotrexate-impurity-d-pa1328040
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PA 13 28040
PA 13 28040

Methotrexate - Impurity D


  • Catalogue No.:PA 13 28040

  • CAS :

    5623-18-7

  • Molecular Formula : C15H14N6O3

  • Molecular Weight : 326.31

stdClass Object
(
    [pname] => Methotrexate - Impurity E (HCl Salt)
    [catalogue_number] => PA 13 28050
    [category_ids] => ,70,71,78,80,82,83,
    [chemical_name] => 
    [weight] => 687.12
    [form] => C30H31ClN14O4
    [cas] => 70844-48-3
    [pslug] => 70844-48-3-methotrexate-impurity-e-hcl-salt-pa1328050
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PA 13 28050
PA 13 28050

Methotrexate - Impurity E (HCl Salt)


  • Catalogue No.:PA 13 28050

  • CAS :

    70844-48-3

  • Molecular Formula : C30H31ClN14O4

  • Molecular Weight : 687.12

stdClass Object
(
    [pname] => Methotrexate - Impurity F (Freebase)
    [catalogue_number] => PA 13 28060
    [category_ids] => ,85,83,69,80,70,78,82,71,
    [chemical_name] => 
    [weight] => 454.44
    [form] => C20H22N8O5
    [cas] => 51865-79-3
    [pslug] => 51865-79-3-methotrexate-impurity-f-freebase-pa1328060
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PA 13 28060
PA 13 28060

Methotrexate - Impurity F (Freebase)


  • Catalogue No.:PA 13 28060

  • CAS :

    51865-79-3

  • Molecular Formula : C20H22N8O5

  • Molecular Weight : 454.44

stdClass Object
(
    [pname] => Methotrexate - Impurity H
    [catalogue_number] => PA 13 28080
    [category_ids] => ,71,82,78,70,80,69,83,85,
    [chemical_name] => 
    [weight] => 468.47
    [form] => C21H24N8O5
    [cas] => 67022-39-3
    [pslug] => 67022-39-3-methotrexate-impurity-h-freebase-pa1328080
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PA 13 28080
PA 13 28080

Methotrexate - Impurity H


  • Catalogue No.:PA 13 28080

  • CAS :

    67022-39-3

  • Molecular Formula : C21H24N8O5

  • Molecular Weight : 468.47

stdClass Object
(
    [pname] => Methotrexate - Impurity I
    [catalogue_number] => PA 13 28090
    [category_ids] => ,71,82,78,70,80,69,83,85,
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    [weight] => 468.47
    [form] => C21H24N8O5
    [cas] => 66147-29-3
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PA 13 28090
PA 13 28090

Methotrexate - Impurity I


  • Catalogue No.:PA 13 28090

  • CAS :

    66147-29-3

  • Molecular Formula : C21H24N8O5

  • Molecular Weight : 468.47

stdClass Object
(
    [pname] => Methopterine-d3
    [catalogue_number] => PA STI 061720
    [category_ids] => ,80,71,98,78,70,82,
    [chemical_name] => 
    [weight] => 458.44
    [form] => C20H18D3N7O6
    [cas] => NA
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PA STI 061720
PA STI 061720

Methopterine-d3


  • Catalogue No.:PA STI 061720

  • CAS :

    NA

  • Molecular Formula : C20H18D3N7O6

  • Molecular Weight : 458.44

stdClass Object
(
    [pname] => Methotrexate-d3
    [catalogue_number] => PA STI 059080
    [category_ids] => ,98,85,83,82,80,78,71,70,69,170,
    [chemical_name] => 
    [weight] => 457.46
    [form] => C20H19D3N8O5
    [cas] => 432545-63-6
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PA STI 059080
PA STI 059080

Methotrexate-d3


  • Catalogue No.:PA STI 059080

  • CAS :

    432545-63-6

  • Molecular Formula : C20H19D3N8O5

  • Molecular Weight : 457.46

stdClass Object
(
    [pname] => DL-Methotrexate-d3 Dipotassium Salt
    [catalogue_number] => PA STI 059090
    [category_ids] => ,80,69,71,85,83,98,78,70,82,
    [chemical_name] => 
    [weight] => 533.64
    [form] => C20H17D3K2N8O5
    [cas] => NA
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PA STI 059090
PA STI 059090

DL-Methotrexate-d3 Dipotassium Salt


  • Catalogue No.:PA STI 059090

  • CAS :

    NA

  • Molecular Formula : C20H17D3K2N8O5

  • Molecular Weight : 533.64

stdClass Object
(
    [pname] => Methotrexate System Suitability Mixture
    [catalogue_number] => PA 13 0281008
    [category_ids] => ,80,71,76,75,93,78,70,82,
    [chemical_name] => 
    [weight] => NA
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    [cas] => NA
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PA 13 0281008
PA 13 0281008

Methotrexate System Suitability Mixture


  • Catalogue No.:PA 13 0281008

  • CAS :

    NA

  • Molecular Formula : NA

  • Molecular Weight : NA

stdClass Object
(
    [pname] => N-(4,6-Diaminopyrimidin-2-yl)nitrous Amide
    [catalogue_number] => PA 13 0281029
    [category_ids] => ,80,69,71,78,70,82,
    [chemical_name] => 
    [weight] => 154.13
    [form] => C4H6N6O
    [cas] => NA
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PA 13 0281029
PA 13 0281029

N-(4,6-Diaminopyrimidin-2-yl)nitrous Amide


  • Catalogue No.:PA 13 0281029

  • CAS :

    NA

  • Molecular Formula : C4H6N6O

  • Molecular Weight : 154.13

stdClass Object
(
    [pname] => N-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzoyl)-N-nitroso-L-glutamic Acid
    [catalogue_number] => PA 13 0281032
    [category_ids] => ,80,69,71,85,83,78,70,82,
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    [weight] => 483.45
    [form] => C20H21N9O6
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PA 13 0281032
PA 13 0281032

N-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzoyl)-N-nitroso-L-glutamic Acid


  • Catalogue No.:PA 13 0281032

  • CAS :

    NA

  • Molecular Formula : C20H21N9O6

  • Molecular Weight : 483.45

stdClass Object
(
    [pname] => N-(4-(((2,4-Diaminopteridin-6-yl)methyl)(nitroso)amino)benzoyl)-N-formyl-L-glutamic Acid
    [catalogue_number] => PA 13 0281033
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    [weight] => 497.43
    [form] => C20H19N9O7
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PA 13 0281033
PA 13 0281033

N-(4-(((2,4-Diaminopteridin-6-yl)methyl)(nitroso)amino)benzoyl)-N-formyl-L-glutamic Acid


  • Catalogue No.:PA 13 0281033

  • CAS :

    NA

  • Molecular Formula : C20H19N9O7

  • Molecular Weight : 497.43

stdClass Object
(
    [pname] => Diethyl (4-(methyl(nitroso)amino)benzoyl)-D-glutamate
    [catalogue_number] => PA 13 0281034
    [category_ids] => ,80,69,71,85,83,78,70,82,
    [chemical_name] => 
    [weight] => 365.39
    [form] => C17H23N3O6
    [cas] => NA
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PA 13 0281034
PA 13 0281034

Diethyl (4-(methyl(nitroso)amino)benzoyl)-D-glutamate


  • Catalogue No.:PA 13 0281034

  • CAS :

    NA

  • Molecular Formula : C17H23N3O6

  • Molecular Weight : 365.39

stdClass Object
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    [pname] => Diethyl N-(4-(methylamino)benzoyl)-N-nitroso-D-glutamate
    [catalogue_number] => PA 13 0281035
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    [weight] => 365.39
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PA 13 0281035
PA 13 0281035

Diethyl N-(4-(methylamino)benzoyl)-N-nitroso-D-glutamate


  • Catalogue No.:PA 13 0281035

  • CAS :

    NA

  • Molecular Formula : C17H23N3O6

  • Molecular Weight : 365.39

stdClass Object
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    [pname] => Diethyl N-(4-(methyl(nitroso)amino)benzoyl)-N-nitroso-D-glutamate
    [catalogue_number] => PA 13 0281036
    [category_ids] => ,80,69,71,85,83,78,70,82,
    [chemical_name] => 
    [weight] => 394.38
    [form] => C17H22N4O7
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PA 13 0281036
PA 13 0281036

Diethyl N-(4-(methyl(nitroso)amino)benzoyl)-N-nitroso-D-glutamate


  • Catalogue No.:PA 13 0281036

  • CAS :

    NA

  • Molecular Formula : C17H22N4O7

  • Molecular Weight : 394.38

stdClass Object
(
    [pname] => N-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzoyl)-N-nitroso-D-glutamic Acid
    [catalogue_number] => PA 13 0281037
    [category_ids] => ,80,69,71,85,83,78,70,82,
    [chemical_name] => 
    [weight] => 483.45
    [form] => C20H21N9O6
    [cas] => NA
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PA 13 0281037
PA 13 0281037

N-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzoyl)-N-nitroso-D-glutamic Acid


  • Catalogue No.:PA 13 0281037

  • CAS :

    NA

  • Molecular Formula : C20H21N9O6

  • Molecular Weight : 483.45

stdClass Object
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    [pname] => Diethyl N-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzoyl)-N-nitroso-L-glutamate
    [catalogue_number] => PA 13 0281038
    [category_ids] => ,80,69,71,85,83,78,70,82,
    [chemical_name] => 
    [weight] => 539.55
    [form] => C24H29N9O6
    [cas] => NA
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PA 13 0281038
PA 13 0281038

Diethyl N-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzoyl)-N-nitroso-L-glutamate


  • Catalogue No.:PA 13 0281038

  • CAS :

    NA

  • Molecular Formula : C24H29N9O6

  • Molecular Weight : 539.55

stdClass Object
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    [catalogue_number] => PA 13 0280061
    [category_ids] => ,69,80,70,78,82,71,
    [chemical_name] => 
    [weight] => 498.41
    [form] => C20H20N8Na2O5
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PA 13 0280061
PA 13 0280061

Methotrexate - Impurity F (Disodium salt)


  • Catalogue No.:PA 13 0280061

  • CAS :

    NA

  • Molecular Formula : C20H20N8Na2O5

  • Molecular Weight : 498.41

stdClass Object
(
    [pname] => (S)-5-Methoxy-4-(4-(methylamino)benzamido)-5-oxopentanoic Acid
    [catalogue_number] => PA 13 0281040
    [category_ids] => ,69,71,78,70,82,
    [chemical_name] => 
    [weight] => 294.31
    [form] => C14H18N2O5
    [cas] => 79974-20-2
    [pslug] => 79974-20-2-s-5-methoxy-4-4-methylamino-benzamido-5-oxopentanoic-acid-pa130281040
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PA 13 0281040
PA 13 0281040

(S)-5-Methoxy-4-(4-(methylamino)benzamido)-5-oxopentanoic Acid


  • Catalogue No.:PA 13 0281040

  • CAS :

    79974-20-2

  • Molecular Formula : C14H18N2O5

  • Molecular Weight : 294.31

stdClass Object
(
    [pname] => 2,4,5,6-Tetraaminopyrimidine Sulfate 
    [catalogue_number] => PA 13 0281041
    [category_ids] => ,82,80,78,71,70,69,
    [chemical_name] => 
    [weight] => 238.22
    [form] => C4H10N6O4S
    [cas] => 5392-28-9
    [pslug] => 5392-28-9-2-4-5-6-tetraaminopyrimidine-sulfate -pa130281041
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PA 13 0281041
PA 13 0281041

2,4,5,6-Tetraaminopyrimidine Sulfate 


  • Catalogue No.:PA 13 0281041

  • CAS :

    5392-28-9

  • Molecular Formula : C4H10N6O4S

  • Molecular Weight : 238.22

stdClass Object
(
    [pname] => Diethyl (4-(methylamino)benzoyl)glutamate
    [catalogue_number] => PA 13 0281042
    [category_ids] => ,82,80,78,71,70,69,
    [chemical_name] => 
    [weight] => 336.39
    [form] => C17H24N2O5
    [cas] => 82778-10-7
    [pslug] => 82778-10-7-diethyl-4-methylamino-benzoyl-glutamate-pa130281042
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PA 13 0281042
PA 13 0281042

Diethyl (4-(methylamino)benzoyl)glutamate


  • Catalogue No.:PA 13 0281042

  • CAS :

    82778-10-7

  • Molecular Formula : C17H24N2O5

  • Molecular Weight : 336.39

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