bortezomib

Bortezomib was approved for medical use in the United States in 2003 and in Europe in 2004. Bortezomib, sold under the brand name Velcade among others, is an anti-cancer medication used to treat multiple myeloma and mantle cell lymphoma.. Reference standards of Bortezomib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below

stdClass Object
(
    [pname] => N-(1-(((R)-1-Hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
    [catalogue_number] => PA 02 79540
    [category_ids] => 90,81,69,78,82,70
    [chemical_name] => 
    [weight] => 356.42
    [form] => C19H24N4O3
    [cas] => 2747958-64-9
    [pslug] => 2747958-64-9-n-1-r-1-hydroxy-3-methylbutyl-amino-1-oxo-3-phenylpropan-2-yl-pyrazine-2-carboxamide-pa0279540
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PA 02 79540

N-(1-(((R)-1-Hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide


  • Catalogue No.:PA 02 79540

  • CAS :

    2747958-64-9

  • Molecular Formula : C19H24N4O3

  • Molecular Weight : 356.42

stdClass Object
(
    [pname] => Bortezomib Amide analog (Mixture of isomers)
    [catalogue_number] => PA 02 79550
    [category_ids] => 90,81,69,70,78,82
    [chemical_name] => 
    [weight] => 270.29
    [form] => C14H14N4O2
    [cas] => 2748159-75-1
    [pslug] => 2748159-75-1-bortezomib-amide-analog-mixture-of-isomers-pa0279550
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PA 02 79550

Bortezomib Amide analog (Mixture of isomers)


  • Catalogue No.:PA 02 79550

  • CAS :

    2748159-75-1

  • Molecular Formula : C14H14N4O2

  • Molecular Weight : 270.29

stdClass Object
(
    [pname] => N-[(1S)-2-[(3-Methylbutyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-2-pyrazinecarboxamide
    [catalogue_number] => PA 02 79560
    [category_ids] => ,69,90,81,78,70,82,
    [chemical_name] => 
    [weight] => 340.42
    [form] => C19H24N4O2
    [cas] => 1446194-56-4
    [pslug] => 1446194-56-4-n-1s-2-3-methylbutyl-amino-2-oxo-1-phenylmethyl-ethyl-2-pyrazinecarboxamide-pa0279560
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PA 02 79560

N-[(1S)-2-[(3-Methylbutyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-2-pyrazinecarboxamide


  • Catalogue No.:PA 02 79560

  • CAS :

    1446194-56-4

  • Molecular Formula : C19H24N4O2

  • Molecular Weight : 340.42

stdClass Object
(
    [pname] => N-(1-(Isopentylamino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
    [catalogue_number] => PA 02 79580
    [category_ids] => 90,81,69,78,82,70
    [chemical_name] => 
    [weight] => 340.42
    [form] => C19H24N4O2
    [cas] => 2797440-80-1
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PA 02 79580

N-(1-(Isopentylamino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide


  • Catalogue No.:PA 02 79580

  • CAS :

    2797440-80-1

  • Molecular Formula : C19H24N4O2

  • Molecular Weight : 340.42

stdClass Object
(
    [pname] => (4-Hydroxy-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic Acid
    [catalogue_number] => PA 02 79590
    [category_ids] => ,69,90,81,78,70,82,
    [chemical_name] => 
    [weight] => 386.21
    [form] => C18H23BN4O5
    [cas] => NA
    [pslug] => 4-hydroxy-1-s-3-phenyl-2-pyrazine-2-carboxamido-propanamido-butyl-boronic-acid-pa0279590
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PA 02 79590

(4-Hydroxy-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic Acid


  • Catalogue No.:PA 02 79590

  • CAS :

    NA

  • Molecular Formula : C18H23BN4O5

  • Molecular Weight : 386.21

stdClass Object
(
    [pname] => N-(1-((1-(3a,5-Dimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
    [catalogue_number] => PA 02 79600
    [category_ids] => ,69,90,81,78,70,82,
    [chemical_name] => 
    [weight] => 504.43
    [form] => C28H37BN4O4
    [cas] => NA
    [pslug] => n-1-1-3a-5-dimethylhexahydro-4-6-methanobenzo-d-1-3-2-dioxaborol-2-yl-3-methylbutyl-amino-1-oxo-3-phenylpropan-2-yl-pyrazine-2-carboxamide-pa0279600
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PA 02 79600

N-(1-((1-(3a,5-Dimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide


  • Catalogue No.:PA 02 79600

  • CAS :

    NA

  • Molecular Formula : C28H37BN4O4

  • Molecular Weight : 504.43

stdClass Object
(
    [pname] => (R)-2-(N-Methylpyrazine-2-carboxamido)-3-phenylpropanoic Acid
    [catalogue_number] => PA 02 79610
    [category_ids] => ,69,90,81,78,70,82,
    [chemical_name] => 
    [weight] => 285.3
    [form] => C15H15N3O3
    [cas] => NA
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PA 02 79610

(R)-2-(N-Methylpyrazine-2-carboxamido)-3-phenylpropanoic Acid


  • Catalogue No.:PA 02 79610

  • CAS :

    NA

  • Molecular Formula : C15H15N3O3

  • Molecular Weight : 285.3

stdClass Object
(
    [pname] => ((R)-3-Methyl-1-((S)-3-phenyl-2-((R)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)propanamido)butyl)boronic Acid
    [catalogue_number] => PA 02 79680
    [category_ids] => 70,69,90
    [chemical_name] => 
    [weight] => 531.41
    [form] => C28H34BN5O5
    [cas] => NA
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PA 02 79680

((R)-3-Methyl-1-((S)-3-phenyl-2-((R)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)propanamido)butyl)boronic Acid


  • Catalogue No.:PA 02 79680

  • CAS :

    NA

  • Molecular Formula : C28H34BN5O5

  • Molecular Weight : 531.41

stdClass Object
(
    [pname] => Bortezomib ((1R,2S)-Bortezomib)
    [catalogue_number] => PA 02 79690
    [category_ids] => ,90,69,70,
    [chemical_name] => 
    [weight] => 1098.67
    [form] => C57H69B3N12O9
    [cas] => 390800-88-1
    [pslug] => 390800-88-1-bortezomib-1r-2s-bortezomib-pa0279690
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PA 02 79690

Bortezomib ((1R,2S)-Bortezomib)


  • Catalogue No.:PA 02 79690

  • CAS :

    390800-88-1

  • Molecular Formula : C57H69B3N12O9

  • Molecular Weight : 1098.67

stdClass Object
(
    [pname] => (1R)-(1S,2S,3R,5S)-Pinanediol-N-(N-pyrazinylphenylalaninoyl)-1-amino-3-methyl-butane-1-boronate
    [catalogue_number] => PA 02 79700
    [category_ids] => ,90,69,70,82,78,
    [chemical_name] => 
    [weight] => 518.46
    [form] => C29H39BN4O4
    [cas] => 205393-22-2
    [pslug] => 205393-22-2-1r-1s-2s-3r-5s-pinanediol-n-n-pyrazinylphenylalaninoyl-1-amino-3-methyl-butane-1-boronate-pa0279700
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PA 02 79700

(1R)-(1S,2S,3R,5S)-Pinanediol-N-(N-pyrazinylphenylalaninoyl)-1-amino-3-methyl-butane-1-boronate


  • Catalogue No.:PA 02 79700

  • CAS :

    205393-22-2

  • Molecular Formula : C29H39BN4O4

  • Molecular Weight : 518.46

stdClass Object
(
    [pname] => (R,R)-Hydroxy Des(boric Acid) Bortezomib
    [catalogue_number] => PA 02 79710
    [category_ids] => ,90,69,70,
    [chemical_name] => 
    [weight] => 356.42
    [form] => C19H24N4O3
    [cas] => NA
    [pslug] => r-r-hydroxy-des-boric-acid-bortezomib-pa0279710
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PA 02 79710

(R,R)-Hydroxy Des(boric Acid) Bortezomib


  • Catalogue No.:PA 02 79710

  • CAS :

    NA

  • Molecular Formula : C19H24N4O3

  • Molecular Weight : 356.42

stdClass Object
(
    [pname] => Bortezomib-D8 (Major)
    [catalogue_number] => PA STI 014210
    [category_ids] => ,69,90,81,78,70,82,98,
    [chemical_name] => 
    [weight] => 392.29
    [form] => C19H17D8BN4O4
    [cas] => NA
    [pslug] => bortezomib-d8-major-pasti014210
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PA STI 014210

Bortezomib-D8 (Major)


  • Catalogue No.:PA STI 014210

  • CAS :

    NA

  • Molecular Formula : C19H17D8BN4O4

  • Molecular Weight : 392.29

stdClass Object
(
    [pname] => (1R,2R)-Bortezomib-d5
    [catalogue_number] => PA STI 014220
    [category_ids] => ,69,90,81,78,70,82,98,
    [chemical_name] => 
    [weight] => 389.27
    [form] => C19H20D5BN4O4
    [cas] => NA
    [pslug] => 1r-2r-bortezomib-d5-pasti014220
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PA STI 014220

(1R,2R)-Bortezomib-d5


  • Catalogue No.:PA STI 014220

  • CAS :

    NA

  • Molecular Formula : C19H20D5BN4O4

  • Molecular Weight : 389.27

stdClass Object
(
    [pname] => (1S,2R)-Bortezomib-d5
    [catalogue_number] => PA STI 014230
    [category_ids] => ,69,90,81,78,70,82,98,
    [chemical_name] => 
    [weight] => 389.27
    [form] => C19H20D5BN4O4
    [cas] => NA
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PA STI 014230

(1S,2R)-Bortezomib-d5


  • Catalogue No.:PA STI 014230

  • CAS :

    NA

  • Molecular Formula : C19H20D5BN4O4

  • Molecular Weight : 389.27

stdClass Object
(
    [pname] => (1S,2S)-Bortezomib-d5
    [catalogue_number] => PA STI 014240
    [category_ids] => ,69,90,81,78,70,82,98,
    [chemical_name] => 
    [weight] => 389.27
    [form] => C19H20D5BN4O4
    [cas] => NA
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PA STI 014240

(1S,2S)-Bortezomib-d5


  • Catalogue No.:PA STI 014240

  • CAS :

    NA

  • Molecular Formula : C19H20D5BN4O4

  • Molecular Weight : 389.27

stdClass Object
(
    [pname] => (1R)-(1S,2S,3R,5S)-Pinanediol-N-(N-pyrazinylphenylalaninoyl)-1-amino-3-methylbutane-1-boronate-d8
    [catalogue_number] => PA STI 073740
    [category_ids] => ,90,69,70,98,
    [chemical_name] => 
    [weight] => 526.50
    [form] => C29H31D8BN4O4
    [cas] => NA
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PA STI 073740

(1R)-(1S,2S,3R,5S)-Pinanediol-N-(N-pyrazinylphenylalaninoyl)-1-amino-3-methylbutane-1-boronate-d8


  • Catalogue No.:PA STI 073740

  • CAS :

    NA

  • Molecular Formula : C29H31D8BN4O4

  • Molecular Weight : 526.50

stdClass Object
(
    [pname] => Bortezomib L-Phenylalanyl Analog
    [catalogue_number] => PA 02 79720
    [category_ids] => 76,71,90,69,70,78,82,79,75
    [chemical_name] => 
    [weight] => 531.42
    [form] => C28H34BN5O5
    [cas] => 1194235-41-0
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PA 02 79720

Bortezomib L-Phenylalanyl Analog


  • Catalogue No.:PA 02 79720

  • CAS :

    1194235-41-0

  • Molecular Formula : C28H34BN5O5

  • Molecular Weight : 531.42

stdClass Object
(
    [pname] => (αR)-(1S,2S,3R,5S)-Pinanediol-1-amino-3-methylbutane-1-boronate Trifluoroacetic Acid Salt
    [catalogue_number] => PA 02 79750
    [category_ids] => ,79,90,69,70,
    [chemical_name] => 
    [weight] => 379.23
    [form] => C17H29BF3NO4
    [cas] => 179324-87-9
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PA 02 79750

(αR)-(1S,2S,3R,5S)-Pinanediol-1-amino-3-methylbutane-1-boronate Trifluoroacetic Acid Salt


  • Catalogue No.:PA 02 79750

  • CAS :

    179324-87-9

  • Molecular Formula : C17H29BF3NO4

  • Molecular Weight : 379.23

stdClass Object
(
    [pname] => (αS)-α-Amino-N-[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]-benzenepropanamide Monohydrochloride
    [catalogue_number] => PA 02 79840
    [category_ids] => ,79,90,69,70,82,
    [chemical_name] => 
    [weight] => 434.81
    [form] => C23H36BClN2O3
    [cas] => 205393-21-1
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PA 02 79840

(αS)-α-Amino-N-[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]-benzenepropanamide Monohydrochloride


  • Catalogue No.:PA 02 79840

  • CAS :

    205393-21-1

  • Molecular Formula : C23H36BClN2O3

  • Molecular Weight : 434.81

stdClass Object
(
    [pname] => N-((R)-1-(((R)-1-Hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
    [catalogue_number] => PA 02 0791038
    [category_ids] => ,90,82,81,78,70,69,
    [chemical_name] => 
    [weight] => 356.43
    [form] => C19H24N4O3
    [cas] => NA
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PA 02 0791038

N-((R)-1-(((R)-1-Hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide


  • Catalogue No.:PA 02 0791038

  • CAS :

    NA

  • Molecular Formula : C19H24N4O3

  • Molecular Weight : 356.43

stdClass Object
(
    [pname] => (1-((S)-3-Phenyl-2-(pyrazine-2-carboxamido)propanamido)pentyl)boronic Acid
    [catalogue_number] => PA 02 0791041
    [category_ids] => ,82,78,70,69,
    [chemical_name] => 
    [weight] => 384.24
    [form] => C19H25BN4O4
    [cas] => NA
    [pslug] => 1-s-3-phenyl-2-pyrazine-2-carboxamido-propanamido-pentyl-boronic-acid-pa020791041
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PA 02 0791041

(1-((S)-3-Phenyl-2-(pyrazine-2-carboxamido)propanamido)pentyl)boronic Acid


  • Catalogue No.:PA 02 0791041

  • CAS :

    NA

  • Molecular Formula : C19H25BN4O4

  • Molecular Weight : 384.24

stdClass Object
(
    [pname] => N-(1-((1-Hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
    [catalogue_number] => PA 02 0791042
    [category_ids] => ,82,78,70,69,
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    [weight] => 356.43
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PA 02 0791042

N-(1-((1-Hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide


  • Catalogue No.:PA 02 0791042

  • CAS :

    2984099-19-4

  • Molecular Formula : C19H24N4O3

  • Molecular Weight : 356.43

stdClass Object
(
    [pname] => rel-(R)-3-Methyl-1-((3aS,4R,6R,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butan-1-amine 2,2,2-trifluoroacetate
    [catalogue_number] => PA 02 0791043
    [category_ids] => ,82,81,78,70,69,
    [chemical_name] => 
    [weight] => 379.23
    [form] => C17H29BF3NO4
    [cas] => 1310383-72-2
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PA 02 0791043

rel-(R)-3-Methyl-1-((3aS,4R,6R,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butan-1-amine 2,2,2-trifluoroacetate


  • Catalogue No.:PA 02 0791043

  • CAS :

    1310383-72-2

  • Molecular Formula : C17H29BF3NO4

  • Molecular Weight : 379.23

stdClass Object
(
    [pname] => Bortezomib Mannitol
    [catalogue_number] => PA 02 0791044
    [category_ids] => ,82,81,78,70,69,
    [chemical_name] => 
    [weight] => 530.39
    [form] => C25H35BN4O8
    [cas] => 444576-08-3
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PA 02 0791044

Bortezomib Mannitol


  • Catalogue No.:PA 02 0791044

  • CAS :

    444576-08-3

  • Molecular Formula : C25H35BN4O8

  • Molecular Weight : 530.39

stdClass Object
(
    [pname] => N-((R)-1-(((R)-1-Hydroperoxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
    [catalogue_number] => PA 02 0791045
    [category_ids] => ,82,78,70,69,
    [chemical_name] => 
    [weight] => 372.43
    [form] => C19H24N4O4
    [cas] => NA
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PA 02 0791045

N-((R)-1-(((R)-1-Hydroperoxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide


  • Catalogue No.:PA 02 0791045

  • CAS :

    NA

  • Molecular Formula : C19H24N4O4

  • Molecular Weight : 372.43

stdClass Object
(
    [pname] => N-((R)-1-(((S)-1-hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
    [catalogue_number] => PA 02 0791046
    [category_ids] => ,90,82,81,78,70,69,
    [chemical_name] => 
    [weight] => 356.43
    [form] => C19H24N4O3
    [cas] => NA
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PA 02 0791046

N-((R)-1-(((S)-1-hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide


  • Catalogue No.:PA 02 0791046

  • CAS :

    NA

  • Molecular Formula : C19H24N4O3

  • Molecular Weight : 356.43

CPHI INDIA- 28, 30 November