dabrafenib
Dabrafenib is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It is used alone or in combination with another medication to treat a type of skin cancer.. Reference standards of Dabrafenib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below
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[pname] => Dabrafenib
[catalogue_number] => PA 31 06000
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[weight] => 519.56
[form] => C23H20F3N5O2S2
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Catalogue No.:PA 31 06000
Molecular Formula : C23H20F3N5O2S2
Molecular Weight : 519.56
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[pname] => 2-Amino-N-(3-(5-(2-aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-6-fluorobenzenesulfonamide
[catalogue_number] => PA 31 0061000
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[weight] => 516.59
[form] => C23H22F2N6O2S2
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2-Amino-N-(3-(5-(2-aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-6-fluorobenzenesulfonamide
Catalogue No.:PA 31 0061000
Molecular Formula : C23H22F2N6O2S2
Molecular Weight : 516.59
stdClass Object
(
[pname] => Carboxy Dabrafenib
[catalogue_number] => PA 31 0061001
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[chemical_name] =>
[weight] => 549.54
[form] => C23H18F3N5O4S2
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Catalogue No.:PA 31 0061001
Molecular Formula : C23H18F3N5O4S2
Molecular Weight : 549.54
stdClass Object
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[pname] => Hydroxy Dabrafenib
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Catalogue No.:PA 31 0061002
Molecular Formula : C23H20F3N5O3S2
Molecular Weight : 535.56
stdClass Object
(
[pname] => Desmethyl Dabrafenib
[catalogue_number] => PA 31 0061003
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[weight] => 505.53
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Catalogue No.:PA 31 0061003
Molecular Formula : C22H18F3N5O2S2
Molecular Weight : 505.53
stdClass Object
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[pname] => 2,4-Difluorobenzenesulfonyl Chloride
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[chemical_name] =>
[weight] => 212.59
[form] => C6H3ClF2O2S
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2,4-Difluorobenzenesulfonyl Chloride
Catalogue No.:PA 31 0061004
Molecular Formula : C6H3ClF2O2S
Molecular Weight : 212.59
stdClass Object
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[pname] => 4-Bromo-2-fluorobenzenesulfonyl Chloride
[catalogue_number] => PA 31 0061005
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[weight] => 273.5
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4-Bromo-2-fluorobenzenesulfonyl Chloride
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[form] => C6H2ClF3O2S
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2,4,6-Trifluorobenzene-1-sulfonyl Chloride
Catalogue No.:PA 31 0061006
Molecular Formula : C6H2ClF3O2S
Molecular Weight : 230.59
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2-Fluoro-6-methoxybenzenesulphonyl Chloride
Catalogue No.:PA 31 0061007
Molecular Formula : C7H6ClFO3S
Molecular Weight : 224.63
stdClass Object
(
[pname] => Methyl 3-amino-4-fluorobenzoate
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[weight] => 169.16
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Methyl 3-amino-4-fluorobenzoate
Catalogue No.:PA 31 0061008
Molecular Formula : C8H8FNO2
Molecular Weight : 169.16
stdClass Object
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Methyl 3-amino-5-fluorobenzoate
Catalogue No.:PA 31 0061009
Molecular Formula : C8H8FNO2
Molecular Weight : 169.16
stdClass Object
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[pname] => Methyl 5-amino-2-fluorobenzoate
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Methyl 5-amino-2-fluorobenzoate
Catalogue No.:PA 31 0061010
Molecular Formula : C8H8FNO2
Molecular Weight : 169.16
stdClass Object
(
[pname] => 3-Amino-2-fluorobenzoic Acid
[catalogue_number] => PA 31 0061011
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[weight] => 155.13
[form] => C7H6FNO2
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3-Amino-2-fluorobenzoic Acid
Catalogue No.:PA 31 0061011
Molecular Formula : C7H6FNO2
Molecular Weight : 155.13
stdClass Object
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[pname] => N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2-fluoro-6-methoxybenzenesulfonamide
[catalogue_number] => PA 31 0061012
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[weight] => 531.6
[form] => C24H23F2N5O3S2
[cas] => NA
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N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2-fluoro-6-methoxybenzenesulfonamide
stdClass Object
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[pname] => 2-Fluoro-6-nitrobenzenesulfonyl Chloride
[catalogue_number] => PA 31 0061013
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[weight] => 239.6
[form] => C6H3ClFNO4S
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2-Fluoro-6-nitrobenzenesulfonyl Chloride
stdClass Object
(
[pname] => Methyl 3-amino-2-methoxybenzoate
[catalogue_number] => PA 31 0061014
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[chemical_name] =>
[weight] => 181.19
[form] => C9H11NO3
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Methyl 3-amino-2-methoxybenzoate
Catalogue No.:PA 31 0061014
Molecular Formula : C9H11NO3
Molecular Weight : 181.19
stdClass Object
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[weight] => 501.57
[form] => C23H21F2N5O2S2
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N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)phenyl)-2,6-difluorobenzenesulfonamide
Catalogue No.:PA 31 0061015
Molecular Formula : C23H21F2N5O2S2
Molecular Weight : 501.57
stdClass Object
(
[pname] => N-(3-(2-(Tert-butyl)-5-(2-(dimethylamino)pyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
[catalogue_number] => PA 31 0061016
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[weight] => 547.62
[form] => C25H24F3N5O2S2
[cas] => NA
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N-(3-(2-(Tert-butyl)-5-(2-(dimethylamino)pyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
Catalogue No.:PA 31 0061016
Molecular Formula : C25H24F3N5O2S2
Molecular Weight : 547.62
stdClass Object
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[catalogue_number] => PA 31 0061017
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[weight] => 551.52
[form] => C22H16F3N5O5S2
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Catalogue No.:PA 31 0061017
Molecular Formula : C22H16F3N5O5S2
Molecular Weight : 551.52
stdClass Object
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[weight] => 503.52
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Catalogue No.:PA 31 0061018
Molecular Formula : C22H16F3N5O2S2
Molecular Weight : 503.52
stdClass Object
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[catalogue_number] => PA 31 0061019
[category_ids] => ,79,80,71,78,70,82,89,88,95,
[chemical_name] =>
[weight] => 695.64
[form] => C28H24F3N5O9S2
[cas] => 2147682-66-2
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Catalogue No.:PA 31 0061019
Molecular Formula : C28H24F3N5O9S2
Molecular Weight : 695.64
stdClass Object
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[weight] => 557
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1-(2-chloropyrimidin-4-yl)-2-(3-((2,6-difluorophenyl)sulfonamido)-2-fluorophenyl)-2-oxoethyl 2,2-dimethylpropanimidothioate
stdClass Object
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[weight] => 345.29
[form] => C14H10F3NO4S
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Methyl 3-((2,6-difluorophenyl)sulfonamido)-2-fluorobenzoate
Catalogue No.:PA 31 0061021
Molecular Formula : C14H10F3NO4S
Molecular Weight : 345.29
stdClass Object
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[catalogue_number] => PA 31 0061022
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[weight] => 520.55
[form] => C23H19F3N4O3S2
[cas] => NA
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N-(3-(2-(tert-Butyl)-5-(2-hydroxypyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
Catalogue No.:PA 31 0061022
Molecular Formula : C23H19F3N4O3S2
Molecular Weight : 520.55
stdClass Object
(
[pname] => 2,6-Difluoro-N-(2-fluoro-3-(2-(2-hydroxypyrimidin-4-yl)acetyl)phenyl)benzenesulfonamide
[catalogue_number] => PA 31 0061023
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[weight] => 423.37
[form] => C18H12F3N3O4S
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2,6-Difluoro-N-(2-fluoro-3-(2-(2-hydroxypyrimidin-4-yl)acetyl)phenyl)benzenesulfonamide
Catalogue No.:PA 31 0061023
Molecular Formula : C18H12F3N3O4S
Molecular Weight : 423.37
stdClass Object
(
[pname] => 2,6-Difluorobenzenesulfonyl Fluoride
[catalogue_number] => PA 31 0061024
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[weight] => 196.14
[form] => C6H3F3O2S
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2,6-Difluorobenzenesulfonyl Fluoride
Catalogue No.:PA 31 0061024
Molecular Formula : C6H3F3O2S
Molecular Weight : 196.14
stdClass Object
(
[pname] => N-(3-(2-(tert-Butyl)-4-hydroxy-5-(2-hydroxypyrimidin-4-yl)-4,5-dihydrothiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
[catalogue_number] => PA 31 0061025
[category_ids] => ,71,78,70,82,
[chemical_name] =>
[weight] => 538.56
[form] => C23H21F3N4O4S2
[cas] => NA
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N-(3-(2-(tert-Butyl)-4-hydroxy-5-(2-hydroxypyrimidin-4-yl)-4,5-dihydrothiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
Catalogue No.:PA 31 0061025
Molecular Formula : C23H21F3N4O4S2
Molecular Weight : 538.56
stdClass Object
(
[pname] => N-(3-(2-(Tert-butyl)-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
[catalogue_number] => PA 31 0061026
[category_ids] => 89,88,80,79,71,82,78,70
[chemical_name] =>
[weight] => 538.99
[form] => C23H18ClF3N4O2S2
[cas] => 1195768-23-0
[pslug] => 1195768-23-0-n-3-2-tert-butyl-5-2-chloropyrimidin-4-yl-thiazol-4-yl-2-fluorophenyl-2-6-difluorobenzenesulfonamide-pa310061026
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N-(3-(2-(Tert-butyl)-5-(2-chloropyrimidin-4-yl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
Catalogue No.:PA 31 0061026
Molecular Formula : C23H18ClF3N4O2S2
Molecular Weight : 538.99
stdClass Object
(
[pname] => Methyl 2-fluoro-3-((2-fluoro-6-hydroxyphenyl)sulfonamido)benzoate
[catalogue_number] => PA 31 0061027
[category_ids] => ,71,78,70,82,
[chemical_name] =>
[weight] => 343.3
[form] => C14H11F2NO5S
[cas] => NA
[pslug] => methyl-2-fluoro-3-2-fluoro-6-hydroxyphenyl-sulfonamido-benzoate-pa310061027
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Methyl 2-fluoro-3-((2-fluoro-6-hydroxyphenyl)sulfonamido)benzoate
stdClass Object
(
[pname] => Dabrafenib Amine Impurity
[catalogue_number] => PA 31 0061028
[category_ids] => ,79,80,71,78,70,82,
[chemical_name] =>
[weight] => 343.42
[form] => C17H18FN5S
[cas] => 1195769-01-7
[pslug] => 1195769-01-7-dabrafenib-amine-impurity-pa310061028
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Dabrafenib Amine Impurity
Catalogue No.:PA 31 0061028
Molecular Formula : C17H18FN5S
Molecular Weight : 343.42
stdClass Object
(
[pname] => N-(3-(2-(2-Aminopyrimidin-4-yl)acetyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
[catalogue_number] => PA 31 0061029
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[chemical_name] =>
[weight] => 422.38
[form] => C18H13F3N4O3S
[cas] => NA
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N-(3-(2-(2-Aminopyrimidin-4-yl)acetyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
Catalogue No.:PA 31 0061029
Molecular Formula : C18H13F3N4O3S
Molecular Weight : 422.38
stdClass Object
(
[pname] => Dabrafenib Diamine Sulfonamide Impurity
[catalogue_number] => PA 31 0061030
[category_ids] => ,78,70,82,
[chemical_name] =>
[weight] => 516.59
[form] => C23H22F2N6O2S2
[cas] => NA
[pslug] => dabrafenib-diamine-sulfonamide-impurity-pa310061030
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Dabrafenib Diamine Sulfonamide Impurity
Catalogue No.:PA 31 0061030
Molecular Formula : C23H22F2N6O2S2
Molecular Weight : 516.59
stdClass Object
(
[pname] => 5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)-4-(3-((2,6-difluorophenyl)sulfonamido)-2-fluorophenyl)thiazole 3-oxide
[catalogue_number] => PA 31 0061031
[category_ids] => ,78,70,82,
[chemical_name] =>
[weight] => 535.56
[form] => C23H20F3N5O3S2
[cas] => NA
[pslug] => 5-2-aminopyrimidin-4-yl-2-tert-butyl-4-3-2-6-difluorophenyl-sulfonamido-2-fluorophenyl-thiazole-3-oxide-pa310061031
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5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)-4-(3-((2,6-difluorophenyl)sulfonamido)-2-fluorophenyl)thiazole 3-oxide
Catalogue No.:PA 31 0061031
Molecular Formula : C23H20F3N5O3S2
Molecular Weight : 535.56
stdClass Object
(
[pname] => 2-Amino-4-(2-(tert-butyl)-4-(3-((2,6-difluorophenyl)sulfonamido)-2-fluorophenyl)thiazol-5-yl)pyrimidine 1-oxide
[catalogue_number] => PA 31 0061032
[category_ids] => ,71,78,70,82,
[chemical_name] =>
[weight] => 535.56
[form] => C23H20F3N5O3S2
[cas] => NA
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2-Amino-4-(2-(tert-butyl)-4-(3-((2,6-difluorophenyl)sulfonamido)-2-fluorophenyl)thiazol-5-yl)pyrimidine 1-oxide
Catalogue No.:PA 31 0061032
Molecular Formula : C23H20F3N5O3S2
Molecular Weight : 535.56
stdClass Object
(
[pname] => Dabrafenib Methoxy Impurity
[catalogue_number] => PA 31 0061033
[category_ids] => ,71,78,70,82,
[chemical_name] =>
[weight] => 534.57
[form] => C24H21F3N4O3S2
[cas] => 1907654-22-1
[pslug] => 1907654-22-1-dabrafenib-methoxy-impurity-pa310061033
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Dabrafenib Methoxy Impurity
Catalogue No.:PA 31 0061033
Molecular Formula : C24H21F3N4O3S2
Molecular Weight : 534.57
stdClass Object
(
[pname] => Dabrafenib des-(tert-butyl)thiazol chloro impurity
[catalogue_number] => PA 31 0061034
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 441.81
[form] => C18H11ClF3N3O3S
[cas] => 1195768-20-7
[pslug] => 1195768-20-7-dabrafenib-des-tert-butyl-thiazol-chloro-impurity-pa310061034
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Dabrafenib des-(tert-butyl)thiazol chloro impurity
Catalogue No.:PA 31 0061034
Molecular Formula : C18H11ClF3N3O3S
Molecular Weight : 441.81
