sacubitril and its Impurities
An antihypertensive drug, Sacubitril is used in combination with valsartan for the treatment of heart ailments. A prodrug of sacubitrilat which is an inhibitor of enzyme neprilysin, which aids the degradation of blood pressure-lowering peptides, atrial and brain natriuretic peptide.Reference standards of Sacubitril API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
3-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-3-oxopropanoic Acid
3-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-3-oxopropanoic Acid
Catalogue No.:PA 19 0661075
CAS :
1027303-80-5
Molecular Formula : C23H27NO5
Molecular Weight : 397.47
Calcium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-isopropoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
Calcium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-isopropoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
Catalogue No.:PA 19 0661076
CAS :
2984580-05-2
Molecular Formula : C50H60CaN2O10
Molecular Weight : 889.11
rel-4-((3R,5S)-5-([1,1'-Biphenyl]-4-ylmethyl)-3-methyl-2-oxopyrrolidin-1-yl)-4-oxobutanoic Acid
rel-4-((3R,5S)-5-([1,1'-Biphenyl]-4-ylmethyl)-3-methyl-2-oxopyrrolidin-1-yl)-4-oxobutanoic Acid
Catalogue No.:PA 19 0661077
CAS :
2216746-87-9
Molecular Formula : C22H23NO4
Molecular Weight : 365.43
5-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-5-oxopentanoic Acid
5-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-5-oxopentanoic Acid
Catalogue No.:PA 19 0661082
CAS :
773820-89-6
Molecular Formula : C25H31NO5
Molecular Weight : 425.53
