Ritlecitinib and its Impurities
Ritlecitinib is a small molecule, being developed by Pfizer, for the oral treatment of ulcerative colitis, alopecia areata, vitiligo, and Crohn's disease. Reference standards of Ritlecitinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

![1-((2S,5R)-5-((1-(3-((2S,5R)-5-((7H-Pyrrolo[2,3-d] PA 18 1471002](https://pharmaffiliates.com/public/pimages/PA181471002.jpg)
1-((2S,5R)-5-((1-(3-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)-3-oxopropyl)-1H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one
1-((2S,5R)-5-((1-(3-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)-3-oxopropyl)-1H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one
Catalogue No.:PA 18 1471002
CAS :
NA
Molecular Formula : C30H38N10O2
Molecular Weight : 570.7

![1-((2S,5S)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)ami PA 18 1471003](https://pharmaffiliates.com/public/pimages/PA181471003.jpg)
1-((2S,5S)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one
1-((2S,5S)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one
Catalogue No.:PA 18 1471003
CAS :
1792181-97-5
Molecular Formula : C15H19N5O
Molecular Weight : 285.35

![1-((2R,5S)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)ami PA 18 1471004](https://pharmaffiliates.com/public/pimages/PA181471004.jpg)
1-((2R,5S)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one
1-((2R,5S)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one
Catalogue No.:PA 18 1471004
CAS :
1792180-79-0
Molecular Formula : C15H19N5O
Molecular Weight : 285.35

![1-((2R,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)ami PA 18 1471005](https://pharmaffiliates.com/public/pimages/PA181471005.jpg)
1-((2R,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one
1-((2R,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one
Catalogue No.:PA 18 1471005
CAS :
1792181-98-6
Molecular Formula : C15H19N5O
Molecular Weight : 285.35


Benzyl (2R,5S)-5-((2,2'-dichloro-7H-[4,7'-bipyrrolo[2,3-d]pyrimidin]-4'-yl)amino)-2-methylpiperidine-1-carboxylate
Benzyl (2R,5S)-5-((2,2'-dichloro-7H-[4,7'-bipyrrolo[2,3-d]pyrimidin]-4'-yl)amino)-2-methylpiperidine-1-carboxylate
Catalogue No.:PA 18 1471008
CAS :
NA
Molecular Formula : C26H24Cl2N8O2
Molecular Weight : 551.43


N-((3R,6S)-6-Methylpiperidin-3-yl)-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
N-((3R,6S)-6-Methylpiperidin-3-yl)-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Catalogue No.:PA 18 1471010
CAS :
NA
Molecular Formula : C18H20N8
Molecular Weight : 348.41

![1-((2S,5R)-5-((6,7-Dihydro-5H-pyrrolo[2,3-d]pyrimi PA 18 1471012](https://pharmaffiliates.com/public/pimages/PA181471012.jpg)
1-((2S,5R)-5-((6,7-Dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one
1-((2S,5R)-5-((6,7-Dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one
Catalogue No.:PA 18 1471012
CAS :
NA
Molecular Formula : C15H21N5O
Molecular Weight : 287.37

![1-((2S,5R)-5-(bis(7H-Pyrrolo[2,3-d]pyrimidin-4-yl) PA 18 1471013](https://pharmaffiliates.com/public/pimages/PA181471013.jpg)
1-((2S,5R)-5-(bis(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one
1-((2S,5R)-5-(bis(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one
Catalogue No.:PA 18 1471013
CAS :
NA
Molecular Formula : C21H22N8O
Molecular Weight : 402.46


N-((3R,6S)-6-Methyl-1-nitrosopiperidin-3-yl)-N-(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)nitrous amide
N-((3R,6S)-6-Methyl-1-nitrosopiperidin-3-yl)-N-(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)nitrous amide
Catalogue No.:PA 18 1471017
CAS :
NA
Molecular Formula : C19H21N7O4S
Molecular Weight : 443.48


N-((3R,6S)-6-Methyl-1-nitrosopiperidin-3-yl)-N-(7-nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-yl)nitrous amide
N-((3R,6S)-6-Methyl-1-nitrosopiperidin-3-yl)-N-(7-nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-yl)nitrous amide
Catalogue No.:PA 18 1471021
CAS :
NA
Molecular Formula : C12H14N8O3
Molecular Weight : 318.30


1-((2S,5R)-2-Methyl-5-((7-nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)prop-2-en-1-one
1-((2S,5R)-2-Methyl-5-((7-nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)prop-2-en-1-one
Catalogue No.:PA 18 1471025
CAS :
NA
Molecular Formula : C15H18N6O2
Molecular Weight : 314.35


N-((3R,6S)-1-Acryloyl-6-methylpiperidin-3-yl)-N-(7-nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-yl)nitrous amide
N-((3R,6S)-1-Acryloyl-6-methylpiperidin-3-yl)-N-(7-nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-yl)nitrous amide
Catalogue No.:PA 18 1471026
CAS :
NA
Molecular Formula : C15H17N7O3
Molecular Weight : 343.35