A multi-targeted tyrosine-kinase inhibitor, Ponatinib is used in treating chronic myeloid leukemia. Shows antiangiogenic and antineoplastic activities.Reference standards of Ponatinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Ponatinib
Catalogue No.:PA 16 91000
CAS :
Molecular Formula : C29H27F3N6O
Molecular Weight : 532.56
3-Ethynylimidazo[1,2-b]pyridazine
Catalogue No.:PA 16 91510
Molecular Formula : C8H5N3
Molecular Weight : 143.15
N-(4-Formyl-3-(trifluoromethyl)phenyl)-3-iodo-4-methylbenzamide
Catalogue No.:PA 16 91520
Molecular Formula : C16H11F3INO2
Molecular Weight : 433.16
N-(4-Formyl-3-(trifluoromethyl)phenyl)-3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide
Catalogue No.:PA 16 91530
Molecular Formula : C24H15F3N4O2
Molecular Weight : 448.4
3-Ethynyl-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
Catalogue No.:PA 16 91540
Molecular Formula : C23H24F3N3O
Molecular Weight : 415.45
3-Bromoimidazo[1,2-b]pyridazine
Catalogue No.:PA 16 91550
Molecular Formula : C6H4BrN3
Molecular Weight : 198.02
3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl)benzamide
Catalogue No.:PA 16 91560
Molecular Formula : C28H25F3N6O
Molecular Weight : 518.53
Ponatinib N-Oxide
Catalogue No.:PA 16 0911000
Molecular Formula : C29H27F3N6O2
Molecular Weight : 548.57
3,3-(Buta-1,3-diyne-1,4-diyl)bis(4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide);
Catalogue No.:PA 16 0911001
Molecular Formula : C46H46F6N6O2
Molecular Weight : 828.9
3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzoic Acid
Catalogue No.:PA 16 0911002
Molecular Formula : C16H11N3O2
Molecular Weight : 277.28
Methyl 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzoate
Catalogue No.:PA 16 0911003
Molecular Formula : C17H13N3O2
Molecular Weight : 291.31
4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline
Catalogue No.:PA 16 0911004
Molecular Formula : C13H18F3N3
Molecular Weight : 273.3
3,5-bis(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
Catalogue No.:PA 16 0911005
Molecular Formula : C37H30F3N9O
Molecular Weight : 673.7
3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-nitrosopiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
Catalogue No.:PA 16 0911006
Molecular Formula : C28H24F3N7O2
Molecular Weight : 547.54
4-((4-Nitrosopiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline
Catalogue No.:PA 16 0911007
Molecular Formula : C12H15F3N4O
Molecular Weight : 288.27
Ponatinib N-beta-D-Glucuronide
Catalogue No.:PA 16 0911008
Molecular Formula : C35H36BrF3N6O7
Molecular Weight : 789.61
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