estradiol benzoate and its Impurities
Estradiol benzoate is used in hormone therapy for the treatment of menopausal symptoms such as hot flashes and vaginal atrophy and in the treatment of hypoestrogenism. It is sold under the brand name Progynon-B.Reference standards of Estradiol Benzoate API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


(5R,6R,8S,9S,10R,13S,14S)-5-Chloro-13-methyltetradecahydro-6,10-(epoxymethano)cyclopenta[a]phenanthrene-3,17-dione
(5R,6R,8S,9S,10R,13S,14S)-5-Chloro-13-methyltetradecahydro-6,10-(epoxymethano)cyclopenta[a]phenanthrene-3,17-dione
Catalogue No.:PA 05 1501002
CAS :
82182-57-8
Molecular Formula : C19H25ClO3
Molecular Weight : 336.86


(3S,5R,6R,8S,9S,10R,13S,14S)-5-Chloro-3-hydroxy-13-methyltetradecahydro-6,10-(epoxymethano)cyclopenta[a]phenanthren-17(1H)-one
(3S,5R,6R,8S,9S,10R,13S,14S)-5-Chloro-3-hydroxy-13-methyltetradecahydro-6,10-(epoxymethano)cyclopenta[a]phenanthren-17(1H)-one
Catalogue No.:PA 05 1501003
CAS :
13244-39-8
Molecular Formula : C19H27ClO3
Molecular Weight : 338.87


(3S,5R,6R,8S,9S,10R,13S,14S)-5-Chloro-6-hydroxy-10,13-dimethyl-17-oxohexadecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate
(3S,5R,6R,8S,9S,10R,13S,14S)-5-Chloro-6-hydroxy-10,13-dimethyl-17-oxohexadecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate
Catalogue No.:PA 05 1501004
CAS :
6557-16-0
Molecular Formula : C21H31ClO4
Molecular Weight : 382.93


(8R,9S,10R,13S,14S)-10,13-Dimethyl-7,8,9,10,11,12,13,14,15,16-decahydrospiro[cyclopenta[a]phenanthrene-17,2'-[1,3]dioxolan]-3(6H)-one
(8R,9S,10R,13S,14S)-10,13-Dimethyl-7,8,9,10,11,12,13,14,15,16-decahydrospiro[cyclopenta[a]phenanthrene-17,2'-[1,3]dioxolan]-3(6H)-one
Catalogue No.:PA 05 1501005
CAS :
2398-63-2
Molecular Formula : C21H28O3
Molecular Weight : 328.45


(8R,9S,13S,14S,17S)-17-Hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl 3-cyclopentylpropanoate
(8R,9S,13S,14S,17S)-17-Hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl 3-cyclopentylpropanoate
Catalogue No.:PA 05 1501001
CAS :
41460-44-0
Molecular Formula : C26H36O3
Molecular Weight : 396.57


(8R,9S,13S,14S,17R)-3-Hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl benzoate
(8R,9S,13S,14S,17R)-3-Hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl benzoate
Catalogue No.:PA 05 1501006
CAS :
182624-52-8
Molecular Formula : C25H28O3
Molecular Weight : 376.5


(8R,9S,13S,14S,17R)-13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diyl dibenzoate
(8R,9S,13S,14S,17R)-13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diyl dibenzoate
Catalogue No.:PA 05 1501007
CAS :
88722-94-5
Molecular Formula : C32H32O4
Molecular Weight : 480.6