amlodipine and its Impurities
Amlodipine is commonly used in the treatment of high blood pressure and angina. Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called dihydropyridine calcium channel blockers. Reference standards of Amlodipine API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Diethyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1-nitroso-1,4-dihydropyridine-3,5-dicarboxylate
Diethyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1-nitroso-1,4-dihydropyridine-3,5-dicarboxylate
Catalogue No.:PA 01 0501014
CAS :
NA
Molecular Formula : C21H26ClN3O6
Molecular Weight : 451.9
Dimethyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1-nitroso-1,4-dihydropyridine-3,5-dicarboxylate
Dimethyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1-nitroso-1,4-dihydropyridine-3,5-dicarboxylate
Catalogue No.:PA 01 0501015
CAS :
NA
Molecular Formula : C19H22ClN3O6
Molecular Weight : 423.85
3-Ethyl 5-methyl 4-(2-chlorophenyl)-2-((2-(2-((2-hydroxyethyl)carbamoyl)benzamido)ethoxy)methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
3-Ethyl 5-methyl 4-(2-chlorophenyl)-2-((2-(2-((2-hydroxyethyl)carbamoyl)benzamido)ethoxy)methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Catalogue No.:PA 01 0491020
CAS :
NA
Molecular Formula : C30H34ClN3O8
Molecular Weight : 600.07
3-Ethyl 5-methyl 4-(2-chlorophenyl)-2-((2-(1,3-dioxoisoindolin-2-yl)ethoxy)methyl)-6-methylpyridine-3,5-dicarboxylate
3-Ethyl 5-methyl 4-(2-chlorophenyl)-2-((2-(1,3-dioxoisoindolin-2-yl)ethoxy)methyl)-6-methylpyridine-3,5-dicarboxylate
Catalogue No.:PAI 01 003301
CAS :
331258-36-7
Molecular Formula : C28H25ClN2O7
Molecular Weight : 536.97
3-Ethyl 5-methyl 4-(2-chlorophenyl)-2-((2-(1,3-dioxoisoindolin-2-yl)ethoxy)methyl)-1,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
3-Ethyl 5-methyl 4-(2-chlorophenyl)-2-((2-(1,3-dioxoisoindolin-2-yl)ethoxy)methyl)-1,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Catalogue No.:PAI 01 003302
CAS :
NA
Molecular Formula : C29H29ClN2O7
Molecular Weight : 553.01
3-Ethyl 5-methyl 4-(2-chlorophenyl)-2,6-bis((2-(1,3-dioxoisoindolin-2-yl)ethoxy)methyl)-1,4-dihydropyridine-3,5-dicarboxylate
3-Ethyl 5-methyl 4-(2-chlorophenyl)-2,6-bis((2-(1,3-dioxoisoindolin-2-yl)ethoxy)methyl)-1,4-dihydropyridine-3,5-dicarboxylate
Catalogue No.:PAI 01 052002
CAS :
223734-99-4
Molecular Formula : C38H34ClN3O10
Molecular Weight : 728.15
3-Ethyl 5-methyl 4-(2-chlorophenyl)-2-((2-hydroxyethoxy)methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
3-Ethyl 5-methyl 4-(2-chlorophenyl)-2-((2-hydroxyethoxy)methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Catalogue No.:PA 01 0491021
CAS :
101411-52-3
Molecular Formula : C20H24ClNO6
Molecular Weight : 409.86
3-Ethyl 5-methyl 4-(2-chlorophenyl)-2-((2-hydroxyethoxy)methyl)-6-methyl-1-nitroso-1,4-dihydropyridine-3,5-dicarboxylate
3-Ethyl 5-methyl 4-(2-chlorophenyl)-2-((2-hydroxyethoxy)methyl)-6-methyl-1-nitroso-1,4-dihydropyridine-3,5-dicarboxylate
Catalogue No.:PA 01 0491022
CAS :
NA
Molecular Formula : C20H23ClN2O7
Molecular Weight : 438.86
3-Ethyl 5-methyl (R)-4-(2-chlorophenyl)-6-methyl-2-((2-(2-(methylcarbamoyl)benzamido)ethoxy)methyl)-1-nitroso-1,4-dihydropyridine-3,5-dicarboxylate
3-Ethyl 5-methyl (R)-4-(2-chlorophenyl)-6-methyl-2-((2-(2-(methylcarbamoyl)benzamido)ethoxy)methyl)-1-nitroso-1,4-dihydropyridine-3,5-dicarboxylate
Catalogue No.:PA 01 0491023
CAS :
NA
Molecular Formula : C29H31ClN4O8
Molecular Weight : 599.04
Methyl 4-(2-chlorophenyl)-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylate
Methyl 4-(2-chlorophenyl)-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylate
Catalogue No.:PA 01 0491025
CAS :
100276-22-0
Molecular Formula : C16H14ClNO4
Molecular Weight : 319.74
(Z)-4-((2-((4-(2-Chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl)methoxy)ethyl)amino)-4-oxobut-2-enoic Acid
(Z)-4-((2-((4-(2-Chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl)methoxy)ethyl)amino)-4-oxobut-2-enoic Acid
Catalogue No.:PA 01 0491030
CAS :
400602-36-0
Molecular Formula : C24H27ClN2O8
Molecular Weight : 506.94
(2-((4-(2-Chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl)methoxy)ethyl)glycine
(2-((4-(2-Chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl)methoxy)ethyl)glycine
Catalogue No.:PA 01 0491031
CAS :
88150-61-2
Molecular Formula : C22H27ClN2O7
Molecular Weight : 466.92
Methyl 5-(chlorocarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate
Methyl 5-(chlorocarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate
Catalogue No.:PA 01 0491033
CAS :
125185-92-4
Molecular Formula : C16H15ClN2O5
Molecular Weight : 350.76
3-Ethyl 5-methyl 4-(2-chlorophenyl)-2-((2-(2-((2-hydroxyethyl)carbamoyl)benzamido)ethoxy)methyl)-6-methyl-1-nitroso-1,4-dihydropyridine-3,5-dicarboxylate
3-Ethyl 5-methyl 4-(2-chlorophenyl)-2-((2-(2-((2-hydroxyethyl)carbamoyl)benzamido)ethoxy)methyl)-6-methyl-1-nitroso-1,4-dihydropyridine-3,5-dicarboxylate
Catalogue No.:PA 01 0491036
CAS :
NA
Molecular Formula : C30H33ClN4O9
Molecular Weight : 629.06
N-(2-((4-(2-Chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl)methoxy)ethyl)-N-nitrosoaspartic Acid
N-(2-((4-(2-Chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl)methoxy)ethyl)-N-nitrosoaspartic Acid
Catalogue No.:PA 01 0491037
CAS :
NA
Molecular Formula : C24H28ClN3O10
Molecular Weight : 553.95
5-Diethyl 3-dimethyl 6,6'-((((isophthaloylbis(azanediyl))bis(ethane-2,1-diyl))bis(oxy))bis(methylene))bis(4-(2-chlorophenyl)-2-methyl-1,4-dihydropyridine-3,5-dicarboxylate)
5-Diethyl 3-dimethyl 6,6'-((((isophthaloylbis(azanediyl))bis(ethane-2,1-diyl))bis(oxy))bis(methylene))bis(4-(2-chlorophenyl)-2-methyl-1,4-dihydropyridine-3,5-dicarboxylate)
Catalogue No.:PA 01 0491038
CAS :
2309467-38-5
Molecular Formula : C48H52Cl2N4O12
Molecular Weight : 947.86
