Name: Acipimox
Brand: Pharmaffliates
Rating: 4.00 (5 reviews)

Catalogue number:	PA 01 3720000
Chemical name:	Acipimox
CAS Number:	51037-30-0
Category:	intermediates,pharmaceutical standards,aromatics,Fine Chemicals,metabolites
Synonyms:	Olbemox; Olbetam; Pyrazinecarboxylic acid, 5-methyl-, 4-oxide; 5-Methylpyrazine-2-carboxylic acid 4-oxide; 5-Methylpyrazinecarboxylic acid 4-oxide; 2-Pyrazinecarboxylic acid, 5-methyl-, 4-oxide;
Molecular form:	C₆H₆N₂O₃
Appearance:	White to Yellow Solid
Mol. Weight:	154.13
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	Acipimox is a niacin derivative used as a hypolipidemic agent. It is used in low doses and may have less marked adverse effects, although it is unclear whether the recommended dose is as effective as are standard doses of nicotinic acid. Acipimox inhibits the production of triglycerides by the liver and the secretion of VLDL, which leads indirectly to a modest reduction in LDL and increase in HDL. Long-term administration is associated with reduced mortality, but unwanted effects limit its clinical use. Adverse effects include flushing (associated with Prostaglandin D2), palpitations, and GI disturbances. Flushing can be reduced by taking aspirin 20-30 min before taking Acipimox. High doses can cause disorders of liver function, impair glucose tolerance and precipitate gout.

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