Name: MC-Gly-Gly-Phe-Gly-GABA-Exatecan
Brand: Pharmaffliates
Rating: 4.00 (5 reviews)

Catalogue number:	PA PEP 002534
Chemical name:	MC-Gly-Gly-Phe-Gly-GABA-Exatecan
CAS Number:	1599439-52-7
Category:	peptides,Antibody Drug Conjugate
Synonyms:	Glycinamide, N-[6-(2,5-dihydroA-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]glycylglycyl-L-phenylalanyl-N-[4-[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-1-yl]amino]-4-oxobutyl]-; N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]glycylglycyl-L-phenylalanyl-N-[4-[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-1-yl]amino]-4-oxobutyl]glycinamide; N-((S)-7-benzyl-16-(((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)amino)-2,5,8,11,16-pentaoxo-3,6,9,12-tetraazahexadecyl)-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide;
Molecular form:	C₅₃H₅₈FN₉O₁₂
Appearance:	NA
Mol. Weight:	1032.10
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	MC-Gly-Gly-Phe-Gly-GABA-Exatecan is an agent linker conjugate for ADC, with an inhibitor for Topoisomerase Exatecan (HY-13631) with IC50 of 22 μM. MC-Gly-Gly-Phe-Gly-GABA-Exatecan targets various antibodies, exhibits cytotoxic and antitumor efficacy in vitro and in vivo

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MC-Gly-Gly-Phe-Gly-GABA-Exatecan

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