Name: MC-SN38
Brand: Pharmaffliates
Rating: 4.00 (5 reviews)

Catalogue number:	PA 03 0061017
Chemical name:	MC-SN38
CAS Number:	1473403-87-0
Category:	chiral standards,heterocycles,enzyme inhibitors,pharmaceutical standards,intermediates,Fine Chemicals,Antibody Drug Conjugate
Synonyms:	1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-9-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-4-yl ester; (4S)-4,11-Diethyl-3,4,12,14-tetrahydro-9-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-4-yl 2,5-dihydro-2,5-dioxo-1H-pyrrole-1-hexanoate; (S)-4,11-diethyl-9-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate;
Molecular form:	C₃₂H₃₁N₃O₈
Appearance:	NA
Mol. Weight:	585.61
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	MC-SN38 is a agent-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody agent conjugate (ADC). SN-38, an active metabolite of the Topoisomerase I inhibitor Irinotecan, inhibits DNA synthesis and causes frequent DNA single-strand breaks

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MC-SN38

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