Name: (S,R,S)-MI-1061
Brand: Pharmaffliates
Rating: 4.00 (5 reviews)

Catalogue number:	PA 27 0031419
Chemical name:	(S,R,S)-MI-1061
CAS Number:	1410738-90-7
Category:	miscellaneous compounds,Antibody Drug Conjugate
Synonyms:	4-((3'S,4'R,5'S)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamido)benzoic acid; Benzoic acid, 4-[[[(3′S,4′R,5′S)-6′′-chloro-4′-(3-chloro-2-fluorophenyl)-1′′,2′′-dihydro-2′′-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3′′-[3H]indol]-5′-yl]carbonyl]amino]-; 4-[[[(3′S,4′R,5′S)-6′′-Chloro-4′-(3-chloro-2-fluorophenyl)-1′′,2′′-dihydro-2′′-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3′′-[3H]indol]-5′-yl]carbonyl]amino]benzoic acid;
Molecular form:	C₃₀H₂₆Cl₂FN₃O₄
Appearance:	NA
Mol. Weight:	582.45
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	(S,R,S)-MI-1061 is the isomer of MI-1061(HY-125858). (S,R,S)-MI-1061 can used to synthesize Antibody-Drug Conjugates (ADCs). MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity

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(S,R,S)-MI-1061

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