Name: DC44SMe
Brand: Pharmaffliates
Rating: 4.00 (5 reviews)

Catalogue number:	PA 27 0031381
Chemical name:	DC44SMe
CAS Number:	1354787-76-0
Category:	miscellaneous compounds,Antibody Drug Conjugate
Synonyms:	(S)-1-(chloromethyl)-3-(5-(5-(4-methyl-4-(methyldisulfaneyl)pentanamido)-1H-indole-2-carboxamido)-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-5-yl dihydrogen phosphate; 1H-Indole-2-carboxamide, N-[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-(phosphonooxy)-3H-benz[e]indol-3-yl]carbonyl]-1H-indol-5-yl]-5-[[4-methyl-4-(methyldithio)-1-oxopentyl]amino]-; N-[2-[[(1S)-1-(Chloromethyl)-1,2-dihydro-5-(phosphonooxy)-3H-benz[e]indol-3-yl]carbonyl]-1H-indol-5-yl]-5-[[4-methyl-4-(methyldithio)-1-oxopentyl]amino]-1H-indole-2-carboxamide;
Molecular form:	C₃₈H₃₇ClN₅O₇PS₂
Appearance:	NA
Mol. Weight:	806.29
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	DC44SMe, a phosphate proagent of cytotoxic DNA alkylator DC44, can be used in the synthesis of antibody-drug conjugate (ADC). DC44SMe exhibits IC50s of 2.0 nM, 2.8 nM, and 1.9 nM for Ramos, Namalwa, and HL60/s cancer cells, respectively. DC44SMe can be used for the targeted treatment of cancer

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