Afatinib

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Afatinib - API

Afatinib - API

Afatinib

Product Code : PA 28 02000
Cas No. : 850140-72-6
Synonyms : (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide; BIBW 2992;
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N-(3,4-dichlorophenyl)-7-fluoro-6-nitroquinazolin-4-amine

N-(3,4-dichlorophenyl)-7-fluoro-6-nitroquinazolin-4-amine

Afatinib - In house impurity

Product Code : PA 28 02510
Cas No. : NA
Synonyms : N-(3,4-dichlorophenyl)-7-fluoro-6-nitroquinazolin-4-amine;
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(S)-N4-(4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine

(S)-N4-(4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine

Afatinib - In house impurity

Product Code : PA 28 02520
Cas No. : NA
Synonyms : (S)-N4-(4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine;
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(S)-N4-phenyl-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine

(S)-N4-phenyl-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine

Afatinib - In house impurity

Product Code : PA 28 02530
Cas No. : NA
Synonyms : (S)-N4-phenyl-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine;
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(S)-N4-(3-chlorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine

(S)-N4-(3-chlorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine

Afatinib - In house impurity

Product Code : PA 28 02540
Cas No. : NA
Synonyms : (S)-N4-(3-chlorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine;
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(S)-N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine

(S)-N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine

Afatinib - In house impurity

Product Code : PA 28 02550
Cas No. : 314771-76-1
Synonyms : Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl (Contained ~8.5% Ethanol); N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4,6-quinazolinediamine; Des(4-dimethylamino-2-en-1-oxo)butyl Afatinib;
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(S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)formamide

(S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)formamide

Afatinib - In house impurity

Product Code : PA 28 02560
Cas No. : NA
Synonyms : Des(N,N-Dimethylprop-2-enyl-1-Amine) Afatinib; Des(4-dimethylamino-2-en-1-oxo)butyl Afatinib N6 Formyl;
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(S)-N-(((4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)methylene)-N-methylmethanaminium

(S)-N-(((4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)methylene)-N-methylmethanaminium

Afatinib - In house impurity

Product Code : PA 28 02570
Cas No. : NA
Synonyms : N-Methylmethanaminium, (S)-N-(((4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)methylene)-;
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1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one

1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one

Afatinib - In house impurity

Product Code : PA 28 02580
Cas No. : NA
Synonyms : Des-(4-dimethylamino-2-en-1-oxo)butylamino 6-(5-Hydroxy-pyrrolidin-2-on-1-yl) Afatinib;
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(S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-3-hydroxybutanamide

(S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-3-hydroxybutanamide

Afatinib - In house impurity

Product Code : PA 28 02590
Cas No. : NA
Synonyms : 3-Hydroxybutanamide, (S)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-;
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(R)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-3-hydroxybutanamide

(R)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-3-hydroxybutanamide

Afatinib - In house impurity

Product Code : PA 28 02600
Cas No. : NA
Synonyms : 3-Hydroxybutanamide, (R)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-
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(S,E)-N-(4-((4-Chloro-3-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

(S,E)-N-(4-((4-Chloro-3-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

Afatinib - In house impurity

Product Code : PA 28 02610
Cas No. : NA
Synonyms : 2-Enamide, (S,E)-N-(4-((4-chloro-3-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-;
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(S,E)-4-(Dimethylamino)-N-(4-((4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide

(S,E)-4-(Dimethylamino)-N-(4-((4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide

Afatinib - In house impurity

Product Code : PA 28 02620
Cas No. : NA
Synonyms : 3-Dechloro Afatinib;
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(S,Z)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

(S,Z)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

Afatinib - In house impurity

Product Code : PA 28 02630
Cas No. : 1680184-59-1
Synonyms : Z-Afatinib; (2Z)-Afatinib;
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(R,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

(R,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

Afatinib - In house impurity

Product Code : PA 28 02640
Cas No. : NA
Synonyms : 2-Enamide, (R,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-;
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(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine

(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine

Afatinib - In house impurity

Product Code : PA 28 02650
Cas No. : 314771-88-5
Synonyms : ((Tetrahydrofuran-3-yl)oxy)quinazolin-4-amine, (S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-;
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(S,E)-N-(4-((3,4-Difluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

(S,E)-N-(4-((3,4-Difluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

Afatinib - In house impurity

Product Code : PA 28 02660
Cas No. : NA
Synonyms : 4-(Dimethylamino)but-2-enamide, (S,E)-N-(4-((3,4-difluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-; Afatinib Difluoro Analog;
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(S,E)-N-(4-((4-Chloro-3-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide

(S,E)-N-(4-((4-Chloro-3-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide

Afatinib - In house impurity

Product Code : PA 28 02670
Cas No. : NA
Synonyms : But-2-enamide, (S,E)-N-(4-((4-chloro-3-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl);
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(S,E)-N-(4-((3,4-Dichlorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

(S,E)-N-(4-((3,4-Dichlorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

Afatinib - In house impurity

Product Code : PA 28 02680
Cas No. : NA
Synonyms : 4-(Dimethylamino)but-2-enamide, (S,E)-N-(4-((3,4-dichlorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-; Afatinib Dichloro Analog;
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(S,E)-4-Bromo-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide

(S,E)-4-Bromo-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide

Afatinib - In house impurity

Product Code : PA 28 02690
Cas No. : NA
Synonyms : But-2-enamide, (S,E)-4-bromo-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl);
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(S,E)-4-(Dimethylamino)-N-(4-hydroxy-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide

(S,E)-4-(Dimethylamino)-N-(4-hydroxy-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide

Afatinib - In house impurity

Product Code : PA 28 02700
Cas No. : NA
Synonyms : But-2-enamide, (S,E)-4-(dimethylamino)-N-(4-hydroxy-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl); Afatinib 4-keto Analog;
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(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(methylamino)but-2-enamide

(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(methylamino)but-2-enamide

Afatinib - In house impurity

Product Code : PA 28 02710
Cas No. : NA
Synonyms : But-2-enamide, (S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(methylamino); N-Desmethyl Afatinib; Afatinib N-Desmethyl;
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Afatinib N-Oxide

Afatinib N-Oxide

Afatinib - In house impurity

Product Code : PA 28 02720
Cas No. : NA
Synonyms : (S,E)-4-((4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-2-yl)oxy)quinazolin-6-yl)amino)-N,N-dimethyl-4-oxobut-2-en-1-amine Oxide;
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(E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide

(E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide

Afatinib - In house impurity

Product Code : PA 28 02730
Cas No. : NA
Synonyms : But-2-enamide, (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-4-(dimethylamino); Afatinib O-Ethyl Analog;
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(E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide

(E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide

Afatinib - In house impurity

Product Code : PA 28 02740
Cas No. : NA
Synonyms : But-2-enamide, (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(dimethylamino); Afatinib O-Methyl Analog;
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(S)-N-(4-((4-Fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)formamide

(S)-N-(4-((4-Fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)formamide

Afatinib - In house impurity

Product Code : PA 28 02750
Cas No. : NA
Synonyms : Formamide, (S)-N-(4-((4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl); Afatinib N-Formoyl Analog;
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(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-hydroxybut-2-enamide

(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-hydroxybut-2-enamide

Afatinib - In house impurity

Product Code : PA 28 02760
Cas No. : NA
Synonyms : 4-Hydroxybut-2-enamide, (S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-; Afatinib 4-Hydroxy-2-butenoic Acid Anlog;
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(S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-3-enamide

(S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-3-enamide

Afatinib - In house impurity

Product Code : PA 28 02770
Cas No. : NA
Synonyms : But-3-enamide, (S)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl); Afatinib 3-Butenoic Acid Analog;
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N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine

N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine

Afatinib - In house impurity

Product Code : PA 28 02780
Cas No. : 179552-74-0
Synonyms : N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitro-4-quinazolinamine; Afatinib Nitro Methoxy Analog;
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1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((R)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one

1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((R)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one

Afatinib - In house impurity

Product Code : PA 28 02790
Cas No. : NA
Synonyms : Des-(4-dimethylamino-2-en-1-oxo)butylamino 6-(5-Hydroxy-pyrrolidin-2-on-1-yl) Afatinib;
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(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide

(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide

Afatinib - In house impurity

Product Code : PA 28 02800
Cas No. : NA
Synonyms : 2-Butenamide, -N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-(2E)-;
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