Ro 106-9920-d5

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Catalogue number:	PA STI 078280
Chemical name:	Ro 106-9920-d5
CAS Number:	NA
Category:	miscellaneous compounds,stable isotopes
Synonyms:	6-[(Phenyl-d5)sulfinyl]tetrazolo[1,5-b]pyridazine;
Molecular form:	C₁₀H₂D₅N₅OS
Appearance:	NA
Mol. Weight:	250.29
Storage:	2-8°C Refrigerator
Shipping Conditions:	Ambient
Applications:	Labelled Ro 106-9920 (R637500). Ro 106-9920 is an inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Ro 106-9920 blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.