axitinib
Axitinib is an indazole derivative. It is most commonly marketed under the name Inlyta® and is available in oral formulations._x000D_ Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3).7. Reference standards of Axitinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
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[pname] => (E)-N-Methyl-2-((1-(2-(pyridin-2-yl)ethyl)-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide
[catalogue_number] => PA 28 45550
[category_ids] => ,80,81,78,70,82,88,
[chemical_name] =>
[weight] => 491.61
[form] => C29H25N5OS
[cas] => 1443118-72-6
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(E)-N-Methyl-2-((1-(2-(pyridin-2-yl)ethyl)-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide
Catalogue No.:PA 28 45550
Molecular Formula : C29H25N5OS
Molecular Weight : 491.61
stdClass Object
(
[pname] => Axitinib N-Glucuronide
[catalogue_number] => PA 28 45560
[category_ids] => ,70,78,80,81,82,88,95,
[chemical_name] =>
[weight] => 562.59
[form] => C28H26N4O7S
[cas] => NA
[pslug] => axitinib-n-glucuronide-pa2845560
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Catalogue No.:PA 28 45560
Molecular Formula : C28H26N4O7S
Molecular Weight : 562.59
stdClass Object
(
[pname] => Axitinib Sulfone Impurity
[catalogue_number] => PA 28 45570
[category_ids] => ,80,81,78,70,82,88,
[chemical_name] =>
[weight] => 418.47
[form] => C22H18N4O3S
[cas] => 1348536-59-3
[pslug] => 1348536-59-3-axitinib-sulfone-impurity-pa2845570
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Axitinib Sulfone Impurity
Catalogue No.:PA 28 45570
Molecular Formula : C22H18N4O3S
Molecular Weight : 418.47
stdClass Object
(
[pname] => 2-(1H-Indazol-6-ylsulfanyl)-N-methylbenzamide
[catalogue_number] => PA 28 45580
[category_ids] => ,80,81,78,70,82,88,
[chemical_name] =>
[weight] => 283.34
[form] => C15H13N3OS
[cas] => 944835-85-2
[pslug] => 944835-85-2-2-1h-indazol-6-ylsulfanyl-n-methylbenzamide-pa2845580
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2-(1H-Indazol-6-ylsulfanyl)-N-methylbenzamide
Catalogue No.:PA 28 45580
Molecular Formula : C15H13N3OS
Molecular Weight : 283.34
stdClass Object
(
[pname] => 2-((3-Iodo-2H-indazol-6-yl)thio)-N-methylbenzamide
[catalogue_number] => PA 28 45590
[category_ids] => ,80,81,78,70,82,88,
[chemical_name] =>
[weight] => 409.24
[form] => C15H12IN3OS
[cas] => 885126-34-1
[pslug] => 885126-34-1-2-3-iodo-2h-indazol-6-yl-thio-n-methylbenzamide-pa2845590
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2-((3-Iodo-2H-indazol-6-yl)thio)-N-methylbenzamide
Catalogue No.:PA 28 45590
Molecular Formula : C15H12IN3OS
Molecular Weight : 409.24
stdClass Object
(
[pname] => Dehydro Axitinib
[catalogue_number] => PA 28 45600
[category_ids] => ,80,81,78,70,82,88,
[chemical_name] =>
[weight] => 388.49
[form] => C22H20N4OS
[cas] => 2749797-54-2
[pslug] => 2749797-54-2-dehydro-axitinib-pa2845600
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Catalogue No.:PA 28 45600
Molecular Formula : C22H20N4OS
Molecular Weight : 388.49
stdClass Object
(
[pname] => Axitinib Amide Impurity
[catalogue_number] => PA 28 45620
[category_ids] => ,80,81,78,70,82,88,
[chemical_name] =>
[weight] => 372.44
[form] => C21H16N4OS
[cas] => 319462-41-4
[pslug] => 319462-41-4-axitinib-amide-impurity-pa2845620
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Catalogue No.:PA 28 45620
Molecular Formula : C21H16N4OS
Molecular Weight : 372.44
stdClass Object
(
[pname] => Axitinib N-THP Impurity
[catalogue_number] => PA 28 45640
[category_ids] => 81,88,70,78,82,80
[chemical_name] =>
[weight] => 470.59
[form] => C27H26N4O2S
[cas] => 885126-35-2
[pslug] => 885126-35-2-axitinib-n-thp-impurity-pa2845640
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Catalogue No.:PA 28 45640
Molecular Formula : C27H26N4O2S
Molecular Weight : 470.59
stdClass Object
(
[pname] => 2-((3-Iodo-1H-indazol-6-yl)sulfinyl)-N-methylbenzamide
[catalogue_number] => PA 28 45700
[category_ids] => ,79,80,71,88,78,
[chemical_name] =>
[weight] => 425.24
[form] => C15H12IN3O2S
[cas] => 1443118-71-5
[pslug] => 1443118-71-5-2-3-iodo-1h-indazol-6-yl-sulfinyl-n-methylbenzamide-pa2845700
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2-((3-Iodo-1H-indazol-6-yl)sulfinyl)-N-methylbenzamide
Catalogue No.:PA 28 45700
Molecular Formula : C15H12IN3O2S
Molecular Weight : 425.24
