Larotrectinib
Larotrectinib (tradename Vitrakvi) is a drug for the treatment of cancer.It is an inhibitor of tropomyosin kinase receptors TrkA, TrkB, and TrkC. It was discovered by Array BioPharma and licensed to Loxo Oncology in 2013. Reference standards of Larotrectinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
stdClass Object
(
[pname] => Larotrectinib
[catalogue_number] => PA 12 1480000
[category_ids] => ,78,75,70,76,82,
[chemical_name] =>
[weight] => 428.44
[form] => C21H22F2N6O2
[cas] => 1223403-58-4
[pslug] => 1223403-58-4-larotrectinib-api-pa121480000
[latest_product] => 0
[linkproducts] => 1
[offers_id] =>
[offers_name] =>
[offers_status] =>
[offers_start_date] =>
[offers_end_date] =>
[pageview] =>
[offers_slug] =>
[offers_product_id] =>
[offers_product_code] =>
[offers_master_id] =>
[offer_percentage] =>
[offers_product_main_cat] =>
)
Catalogue No.:PA 12 1480000
Molecular Formula : C21H22F2N6O2
Molecular Weight : 428.44
stdClass Object
(
[pname] => (S)-N-(5-Chloropyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
[catalogue_number] => PA 12 1481000
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 281.7
[form] => C11H12ClN5O2
[cas] => 2226370-52-9
[pslug] => 2226370-52-9-s-n-5-chloropyrazolo-1-5-a-pyrimidin-3-yl-3-hydroxypyrrolidine-1-carboxamide-pa121481000
[latest_product] => 0
[linkproducts] => 0
[offers_id] =>
[offers_name] =>
[offers_status] =>
[offers_start_date] =>
[offers_end_date] =>
[pageview] =>
[offers_slug] =>
[offers_product_id] =>
[offers_product_code] =>
[offers_master_id] =>
[offer_percentage] =>
[offers_product_main_cat] =>
)
(S)-N-(5-Chloropyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
stdClass Object
(
[pname] => (S)-1-benzyl-3-hydroxypyrrolidine-2,5-dione
[catalogue_number] => PA 12 1481002
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 205.21
[form] => C11H11NO3
[cas] => 101469-91-4
[pslug] => 101469-91-4-s-1-benzyl-3-hydroxypyrrolidine-2-5-dione-pa121481002
[latest_product] => 0
[linkproducts] => 0
[offers_id] =>
[offers_name] =>
[offers_status] =>
[offers_start_date] =>
[offers_end_date] =>
[pageview] =>
[offers_slug] =>
[offers_product_id] =>
[offers_product_code] =>
[offers_master_id] =>
[offer_percentage] =>
[offers_product_main_cat] =>
)
(S)-1-benzyl-3-hydroxypyrrolidine-2,5-dione
Catalogue No.:PA 12 1481002
Molecular Formula : C11H11NO3
Molecular Weight : 205.21
stdClass Object
(
[pname] => (S)-1-benzylpyrrolidin-3-ol
[catalogue_number] => PA 12 1481001
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 177.25
[form] => C11H15NO
[cas] => 101385-90-4
[pslug] => 101385-90-4-s-1-benzylpyrrolidin-3-ol-pa121481001
[latest_product] => 0
[linkproducts] => 0
[offers_id] =>
[offers_name] =>
[offers_status] =>
[offers_start_date] =>
[offers_end_date] =>
[pageview] =>
[offers_slug] =>
[offers_product_id] =>
[offers_product_code] =>
[offers_master_id] =>
[offer_percentage] =>
[offers_product_main_cat] =>
)
(S)-1-benzylpyrrolidin-3-ol
Catalogue No.:PA 12 1481001
Molecular Formula : C11H15NO
Molecular Weight : 177.25
stdClass Object
(
[pname] => Larotrectinib Open-Ring Dimer
[catalogue_number] => PA 12 1481003
[category_ids] => ,78,75,70,76,82,
[chemical_name] =>
[weight] => 515.57
[form] => C25H31F2N7O3
[cas] => NA
[pslug] => larotrectinib-open-ring-dimer-pa121481003
[latest_product] => 0
[linkproducts] => 0
[offers_id] =>
[offers_name] =>
[offers_status] =>
[offers_start_date] =>
[offers_end_date] =>
[pageview] =>
[offers_slug] =>
[offers_product_id] =>
[offers_product_code] =>
[offers_master_id] =>
[offer_percentage] =>
[offers_product_main_cat] =>
)
Larotrectinib Open-Ring Dimer
Catalogue No.:PA 12 1481003
Molecular Formula : C25H31F2N7O3
Molecular Weight : 515.57
stdClass Object
(
[pname] => 1-(4-Bromo-3-fluorophenyl)ethan-1-one
[catalogue_number] => PA 12 1481004
[category_ids] => ,78,75,70,76,82,
[chemical_name] =>
[weight] => 217.04
[form] => C8H6BrFO
[cas] => 304445-49-6
[pslug] => 304445-49-6-1-4-bromo-3-fluorophenyl-ethan-1-one-pa121481004
[latest_product] => 0
[linkproducts] => 0
[offers_id] =>
[offers_name] =>
[offers_status] =>
[offers_start_date] =>
[offers_end_date] =>
[pageview] =>
[offers_slug] =>
[offers_product_id] =>
[offers_product_code] =>
[offers_master_id] =>
[offer_percentage] =>
[offers_product_main_cat] =>
)
1-(4-Bromo-3-fluorophenyl)ethan-1-one
Catalogue No.:PA 12 1481004
Molecular Formula : C8H6BrFO
Molecular Weight : 217.04
stdClass Object
(
[pname] => 4-Acetyl-2-fluorobenzonitrile
[catalogue_number] => PA 12 1481005
[category_ids] => ,78,75,70,76,82,
[chemical_name] =>
[weight] => 163.15
[form] => C9H6FNO
[cas] => 214760-18-6
[pslug] => 214760-18-6-4-acetyl-2-fluorobenzonitrile-pa121481005
[latest_product] => 0
[linkproducts] => 0
[offers_id] =>
[offers_name] =>
[offers_status] =>
[offers_start_date] =>
[offers_end_date] =>
[pageview] =>
[offers_slug] =>
[offers_product_id] =>
[offers_product_code] =>
[offers_master_id] =>
[offer_percentage] =>
[offers_product_main_cat] =>
)
4-Acetyl-2-fluorobenzonitrile
Catalogue No.:PA 12 1481005
Molecular Formula : C9H6FNO
Molecular Weight : 163.15
stdClass Object
(
[pname] => (R)-5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine
[catalogue_number] => PA 12 1481006
[category_ids] => ,78,75,70,76,82,
[chemical_name] =>
[weight] => 315.33
[form] => C16H15F2N5
[cas] => 1223404-88-3
[pslug] => 1223404-88-3-r-5-2-2-5-difluorophenyl-pyrrolidin-1-yl-pyrazolo-1-5-a-pyrimidin-3-amine-pa121481006
[latest_product] => 0
[linkproducts] => 0
[offers_id] =>
[offers_name] =>
[offers_status] =>
[offers_start_date] =>
[offers_end_date] =>
[pageview] =>
[offers_slug] =>
[offers_product_id] =>
[offers_product_code] =>
[offers_master_id] =>
[offer_percentage] =>
[offers_product_main_cat] =>
)
(R)-5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine
Catalogue No.:PA 12 1481006
Molecular Formula : C16H15F2N5
Molecular Weight : 315.33
stdClass Object
(
[pname] => 1,3-Bis(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)urea
[catalogue_number] => PA 12 1481007
[category_ids] => ,78,75,70,76,82,
[chemical_name] =>
[weight] => 656.65
[form] => C33H28F4N10O
[cas] => NA
[pslug] => 1-3-bis-5-r-2-2-5-difluorophenyl-pyrrolidin-1-yl-pyrazolo-1-5-a-pyrimidin-3-yl-urea-pa121481007
[latest_product] => 0
[linkproducts] => 0
[offers_id] =>
[offers_name] =>
[offers_status] =>
[offers_start_date] =>
[offers_end_date] =>
[pageview] =>
[offers_slug] =>
[offers_product_id] =>
[offers_product_code] =>
[offers_master_id] =>
[offer_percentage] =>
[offers_product_main_cat] =>
)
1,3-Bis(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)urea
Catalogue No.:PA 12 1481007
Molecular Formula : C33H28F4N10O
Molecular Weight : 656.65
stdClass Object
(
[pname] => (R)-N-(5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-2,3-dihydro-1H-pyrrole-1-carboxamide
[catalogue_number] => PA 12 1481008
[category_ids] => ,78,75,70,76,82,
[chemical_name] =>
[weight] => 410.43
[form] => C21H20F2N6O
[cas] => NA
[pslug] => r-n-5-2-2-5-difluorophenyl-pyrrolidin-1-yl-pyrazolo-1-5-a-pyrimidin-3-yl-2-3-dihydro-1h-pyrrole-1-carboxamide-pa121481008
[latest_product] => 0
[linkproducts] => 0
[offers_id] =>
[offers_name] =>
[offers_status] =>
[offers_start_date] =>
[offers_end_date] =>
[pageview] =>
[offers_slug] =>
[offers_product_id] =>
[offers_product_code] =>
[offers_master_id] =>
[offer_percentage] =>
[offers_product_main_cat] =>
)
(R)-N-(5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-2,3-dihydro-1H-pyrrole-1-carboxamide
Catalogue No.:PA 12 1481008
Molecular Formula : C21H20F2N6O
Molecular Weight : 410.43
stdClass Object
(
[pname] => (R)-N-(5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-2,3-dihydro-1H-pyrrole-1-carboxamide
[catalogue_number] => PA 12 1481009
[category_ids] => ,78,75,70,76,82,
[chemical_name] =>
[weight] => 426.43
[form] => C21H20F2N6O2
[cas] => 2699151-02-3
[pslug] => 2699151-02-3-r-n-5-2-2-5-difluorophenyl-pyrrolidin-1-yl-pyrazolo-1-5-a-pyrimidin-3-yl-2-3-dihydro-1h-pyrrole-1-carboxamide-pa121481009
[latest_product] => 0
[linkproducts] => 0
[offers_id] =>
[offers_name] =>
[offers_status] =>
[offers_start_date] =>
[offers_end_date] =>
[pageview] =>
[offers_slug] =>
[offers_product_id] =>
[offers_product_code] =>
[offers_master_id] =>
[offer_percentage] =>
[offers_product_main_cat] =>
)
(R)-N-(5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-2,3-dihydro-1H-pyrrole-1-carboxamide
Catalogue No.:PA 12 1481009
Molecular Formula : C21H20F2N6O2
Molecular Weight : 426.43
stdClass Object
(
[pname] => (2R)-2-(2,5-Difluorophenyl)-1-(3-((S)-3-hydroxypyrrolidine-1-carboxamido)pyrazolo[1,5-a]pyrimidin-5-yl)pyrrolidine 1-oxide
[catalogue_number] => PA 12 1481010
[category_ids] => ,78,75,70,76,82,
[chemical_name] =>
[weight] => 444.44
[form] => C21H22F2N6O3
[cas] => NA
[pslug] => 2r-2-2-5-difluorophenyl-1-3-s-3-hydroxypyrrolidine-1-carboxamido-pyrazolo-1-5-a-pyrimidin-5-yl-pyrrolidine-1-oxide-pa121481010
[latest_product] => 0
[linkproducts] => 0
[offers_id] =>
[offers_name] =>
[offers_status] =>
[offers_start_date] =>
[offers_end_date] =>
[pageview] =>
[offers_slug] =>
[offers_product_id] =>
[offers_product_code] =>
[offers_master_id] =>
[offer_percentage] =>
[offers_product_main_cat] =>
)
(2R)-2-(2,5-Difluorophenyl)-1-(3-((S)-3-hydroxypyrrolidine-1-carboxamido)pyrazolo[1,5-a]pyrimidin-5-yl)pyrrolidine 1-oxide
Catalogue No.:PA 12 1481010
Molecular Formula : C21H22F2N6O3
Molecular Weight : 444.44
