Upadacitinib-impurities | Pharmaffiliates

Upadacitinib

Upadacitinib, sold under the brand name Rinvoq, is a Janus kinase (JAK) inhibitor medication for the treatment of moderately to severely active rheumatoid arthritis in adults. where, its methotrexate a drug used to treat active arthritis. Reference standards of Upadacitinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

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    [catalogue_number] => PA 21 0180000
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    [chemical_name] => 
    [weight] => 380.38
    [form] => C17H19F3N6O
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PA 21 0180000

Upadacitinib - API Standards


  • Catalogue No.:PA 21 0180000

  • CAS :

    1310726-60-3

  • Molecular Formula : C17H19F3N6O

  • Molecular Weight : 380.38

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    [pname] => (3S,4S)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide
    [catalogue_number] => PA 21 0181000
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    [weight] => 380.38
    [form] => C17H19F3N6O
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PA 21 0181000

(3S,4S)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide


  • Catalogue No.:PA 21 0181000

  • CAS :

    NA

  • Molecular Formula : C17H19F3N6O

  • Molecular Weight : 380.38

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    [pname] => (3R,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide
    [catalogue_number] => PA 21 0181002
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    [weight] => 380.38
    [form] => C17H19F3N6O
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PA 21 0181002

(3R,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide


  • Catalogue No.:PA 21 0181002

  • CAS :

    NA

  • Molecular Formula : C17H19F3N6O

  • Molecular Weight : 380.38

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    [pname] => (3S,4R)-3-Ethyl-4-(3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide
    [catalogue_number] => PA 21 0181003
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 534.56
    [form] => C24H25F3N6O3S
    [cas] => 2411540-30-0
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PA 21 0181003

(3S,4R)-3-Ethyl-4-(3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide


  • Catalogue No.:PA 21 0181003

  • CAS :

    2411540-30-0

  • Molecular Formula : C24H25F3N6O3S

  • Molecular Weight : 534.56

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    [pname] => Benzyl (3S,4S)-3-acetyl-4-ethylpyrrolidine-1-carboxylate
    [catalogue_number] => PA 21 0181004
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    [chemical_name] => 
    [weight] => 275.35
    [form] => C16H21NO3
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PA 21 0181004

Benzyl (3S,4S)-3-acetyl-4-ethylpyrrolidine-1-carboxylate


  • Catalogue No.:PA 21 0181004

  • CAS :

    2868258-95-9

  • Molecular Formula : C16H21NO3

  • Molecular Weight : 275.35

stdClass Object
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    [pname] => Benzyl (3R,4S)-3-(2,2-dibromoacetyl)-4-ethylpyrrolidine-1-carboxylate
    [catalogue_number] => PA 21 0181005
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 433.14
    [form] => C16H19Br2NO3
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PA 21 0181005

Benzyl (3R,4S)-3-(2,2-dibromoacetyl)-4-ethylpyrrolidine-1-carboxylate


  • Catalogue No.:PA 21 0181005

  • CAS :

    NA

  • Molecular Formula : C16H19Br2NO3

  • Molecular Weight : 433.14

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    [pname] => 8-((3R,4S)-4-Ethylpyrrolidin-3-yl)-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine
    [catalogue_number] => PA 21 0181006
    [category_ids] => ,75,76,78,70,82,
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    [weight] => 255.33
    [form] => C14H17N5
    [cas] => 1708997-43-6
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PA 21 0181006

8-((3R,4S)-4-Ethylpyrrolidin-3-yl)-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine


  • Catalogue No.:PA 21 0181006

  • CAS :

    1708997-43-6

  • Molecular Formula : C14H17N5

  • Molecular Weight : 255.33

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    [pname] => (3R,4S)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide
    [catalogue_number] => PA 21 0181007
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    [weight] => 380.38
    [form] => C17H19F3N6O
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PA 21 0181007

(3R,4S)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide


  • Catalogue No.:PA 21 0181007

  • CAS :

    1310726-59-0

  • Molecular Formula : C17H19F3N6O

  • Molecular Weight : 380.38

stdClass Object
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    [pname] => rel-(3R,4S)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide
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    [weight] => 380.38
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PA 21 0181008

rel-(3R,4S)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide


  • Catalogue No.:PA 21 0181008

  • CAS :

    1831899-72-9

  • Molecular Formula : C17H19F3N6O

  • Molecular Weight : 380.38

stdClass Object
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    [pname] => (3S,4R)-3-Ethyl-4-(3-nitroso-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide
    [catalogue_number] => PA 21 0181009
    [category_ids] => ,70,75,76,78,82,162,
    [chemical_name] => 
    [weight] => 409.37
    [form] => C17H18F3N7O2
    [cas] => NA
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PA 21 0181009

(3S,4R)-3-Ethyl-4-(3-nitroso-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide


  • Catalogue No.:PA 21 0181009

  • CAS :

    NA

  • Molecular Formula : C17H18F3N7O2

  • Molecular Weight : 409.37

stdClass Object
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    [pname] => (S)-N-Ethyl-3-(3-nitroso-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide
    [catalogue_number] => PA 21 0181010
    [category_ids] => ,70,75,76,78,82,
    [chemical_name] => 
    [weight] => 409.37
    [form] => C17H18F3N7O2
    [cas] => NA
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PA 21 0181010

(S)-N-Ethyl-3-(3-nitroso-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide


  • Catalogue No.:PA 21 0181010

  • CAS :

    NA

  • Molecular Formula : C17H18F3N7O2

  • Molecular Weight : 409.37

stdClass Object
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    [pname] => Benzyl (3R,4S)-3-(2-chloroacetyl)-4-ethylpyrrolidine-1-carboxylate
    [catalogue_number] => PA 21 0181011
    [category_ids] => ,70,75,76,78,82,
    [chemical_name] => 
    [weight] => 309.79
    [form] => C16H20ClNO3
    [cas] => 2460133-49-5
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PA 21 0181011

Benzyl (3R,4S)-3-(2-chloroacetyl)-4-ethylpyrrolidine-1-carboxylate


  • Catalogue No.:PA 21 0181011

  • CAS :

    2460133-49-5

  • Molecular Formula : C16H20ClNO3

  • Molecular Weight : 309.79

stdClass Object
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    [pname] => (3S,4R)-3-Ethyl-4-(3-(hydroxymethyl)-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide
    [catalogue_number] => PA 21 0181012
    [category_ids] => ,70,75,76,78,82,
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    [weight] => 410.4
    [form] => C18H21F3N6O2
    [cas] => NA
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PA 21 0181012

(3S,4R)-3-Ethyl-4-(3-(hydroxymethyl)-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide


  • Catalogue No.:PA 21 0181012

  • CAS :

    NA

  • Molecular Formula : C18H21F3N6O2

  • Molecular Weight : 410.4

stdClass Object
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    [pname] => Benzyl (3S,4S)-3-(2-bromoacetyl)-4-ethylpyrrolidine-1-carboxylate
    [catalogue_number] => PA 21 0181013
    [category_ids] => ,70,75,76,78,82,
    [chemical_name] => 
    [weight] => 354.24
    [form] => C16H20BrNO3
    [cas] => 2868258-96-0
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PA 21 0181013

Benzyl (3S,4S)-3-(2-bromoacetyl)-4-ethylpyrrolidine-1-carboxylate


  • Catalogue No.:PA 21 0181013

  • CAS :

    2868258-96-0

  • Molecular Formula : C16H20BrNO3

  • Molecular Weight : 354.24

stdClass Object
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    [pname] => N-Methyl Upadacitinib
    [catalogue_number] => PA 21 0181021
    [category_ids] => ,70,75,76,78,82,
    [chemical_name] => 
    [weight] => 394.4
    [form] => C18H21F3N6O
    [cas] => NA
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PA 21 0181021

N-Methyl Upadacitinib


  • Catalogue No.:PA 21 0181021

  • CAS :

    NA

  • Molecular Formula : C18H21F3N6O

  • Molecular Weight : 394.4

stdClass Object
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    [pname] => 8-((3R,4S)-4-Ethylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine
    [catalogue_number] => PA 21 0181014
    [category_ids] => ,70,75,76,78,82,
    [chemical_name] => 
    [weight] => 409.51
    [form] => C21H23N5O2S
    [cas] => 1428243-28-0
    [pslug] => 1428243-28-0-8-3r-4s-4-ethylpyrrolidin-3-yl-3-tosyl-3h-imidazo-1-2-a-pyrrolo-2-3-e-pyrazine-pa210181014
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PA 21 0181014

8-((3R,4S)-4-Ethylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine


  • Catalogue No.:PA 21 0181014

  • CAS :

    1428243-28-0

  • Molecular Formula : C21H23N5O2S

  • Molecular Weight : 409.51

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    [pname] => 8-((3R,4S)-4-Ethyl-1-tosylpyrrolidin-3-yl)-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine
    [catalogue_number] => PA 21 0181015
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    [weight] => 409.51
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PA 21 0181015

8-((3R,4S)-4-Ethyl-1-tosylpyrrolidin-3-yl)-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine


  • Catalogue No.:PA 21 0181015

  • CAS :

    2952578-02-6

  • Molecular Formula : C21H23N5O2S

  • Molecular Weight : 409.51

stdClass Object
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    [pname] => 1-((3S,4R)-3-Ethyl-4-(3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)pyrrolidin-1-yl)-2,2,2-trifluoroethan-1-one
    [catalogue_number] => PA 21 0181016
    [category_ids] => ,70,75,76,78,82,
    [chemical_name] => 
    [weight] => 505.52
    [form] => C23H22F3N5O3S
    [cas] => 2768445-19-6
    [pslug] => 2768445-19-6-1-3s-4r-3-ethyl-4-3-tosyl-3h-imidazo-1-2-a-pyrrolo-2-3-e-pyrazin-8-yl-pyrrolidin-1-yl-2-2-2-trifluoroethan-1-one-pa210181016
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PA 21 0181016

1-((3S,4R)-3-Ethyl-4-(3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)pyrrolidin-1-yl)-2,2,2-trifluoroethan-1-one


  • Catalogue No.:PA 21 0181016

  • CAS :

    2768445-19-6

  • Molecular Formula : C23H22F3N5O3S

  • Molecular Weight : 505.52

stdClass Object
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    [pname] => 8-((3R,4S)-4-Ethyl-1-tosylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine
    [catalogue_number] => PA 21 0181017
    [category_ids] => ,70,75,76,78,82,
    [chemical_name] => 
    [weight] => 563.69
    [form] => C28H29N5O4S2
    [cas] => NA
    [pslug] => 8-3r-4s-4-ethyl-1-tosylpyrrolidin-3-yl-3-tosyl-3h-imidazo-1-2-a-pyrrolo-2-3-e-pyrazine-pa210181017
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PA 21 0181017

8-((3R,4S)-4-Ethyl-1-tosylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine


  • Catalogue No.:PA 21 0181017

  • CAS :

    NA

  • Molecular Formula : C28H29N5O4S2

  • Molecular Weight : 563.69

stdClass Object
(
    [pname] => Benzyl (3S,4R)-3-ethyl-4-(3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)pyrrolidine-1-carboxylate
    [catalogue_number] => PA 21 0181018
    [category_ids] => ,70,75,76,78,82,
    [chemical_name] => 
    [weight] => 543.64
    [form] => C29H29N5O4S
    [cas] => 1708997-42-5
    [pslug] => 1708997-42-5-benzyl-3s-4r-3-ethyl-4-3-tosyl-3h-imidazo-1-2-a-pyrrolo-2-3-e-pyrazin-8-yl-pyrrolidine-1-carboxylate-pa210181018
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PA 21 0181018

Benzyl (3S,4R)-3-ethyl-4-(3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)pyrrolidine-1-carboxylate


  • Catalogue No.:PA 21 0181018

  • CAS :

    1708997-42-5

  • Molecular Formula : C29H29N5O4S

  • Molecular Weight : 543.64

stdClass Object
(
    [pname] => (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)pyrrolidine-1-carboxamide
    [catalogue_number] => PA 21 0181019
    [category_ids] => ,70,75,76,78,82,
    [chemical_name] => 
    [weight] => 298.35
    [form] => C15H18N6O
    [cas] => NA
    [pslug] => 3s-4r-3-ethyl-4-3h-imidazo-1-2-a-pyrrolo-2-3-e-pyrazin-8-yl-pyrrolidine-1-carboxamide-pa210181019
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PA 21 0181019

(3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)pyrrolidine-1-carboxamide


  • Catalogue No.:PA 21 0181019

  • CAS :

    NA

  • Molecular Formula : C15H18N6O

  • Molecular Weight : 298.35

stdClass Object
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    [pname] => 8-((3R,4S)-4-Ethyl-1-((2,2,2-trifluoroethyl)carbamoyl)pyrrolidin-3-yl)-N-(2,2,2-trifluoroethyl)-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine-3-carboxamide
    [catalogue_number] => PA 21 0181020
    [category_ids] => ,70,75,76,78,82,
    [chemical_name] => 
    [weight] => 505.43
    [form] => C20H21F6N7O2
    [cas] => 2715120-86-6
    [pslug] => 2715120-86-6-8-3r-4s-4-ethyl-1-2-2-2-trifluoroethyl-carbamoyl-pyrrolidin-3-yl-n-2-2-2-trifluoroethyl-3h-imidazo-1-2-a-pyrrolo-2-3-e-pyrazine-3-carboxamide-pa210181020
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PA 21 0181020

8-((3R,4S)-4-Ethyl-1-((2,2,2-trifluoroethyl)carbamoyl)pyrrolidin-3-yl)-N-(2,2,2-trifluoroethyl)-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine-3-carboxamide


  • Catalogue No.:PA 21 0181020

  • CAS :

    2715120-86-6

  • Molecular Formula : C20H21F6N7O2

  • Molecular Weight : 505.43

stdClass Object
(
    [pname] => Benzyl (3R,4S)-3-acetyl-4-ethylpyrrolidine-1-carboxylate
    [catalogue_number] => PA 21 0181022
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 275.35
    [form] => C16H21NO3
    [cas] => 2411540-29-7
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PA 21 0181022

Benzyl (3R,4S)-3-acetyl-4-ethylpyrrolidine-1-carboxylate


  • Catalogue No.:PA 21 0181022

  • CAS :

    2411540-29-7

  • Molecular Formula : C16H21NO3

  • Molecular Weight : 275.35

stdClass Object
(
    [pname] => (3R,4S)-3-Ethyl-4-(3-(hydroxymethyl)-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide
    [catalogue_number] => PA 21 0181023
    [category_ids] => ,70,75,76,78,82,
    [chemical_name] => 
    [weight] => 410.4
    [form] => C18H21F3N6O2
    [cas] => NA
    [pslug] => 3r-4s-3-ethyl-4-3-hydroxymethyl-3h-imidazo-1-2-a-pyrrolo-2-3-e-pyrazin-8-yl-n-2-2-2-trifluoroethyl-pyrrolidine-1-carboxamide-pa210181023
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PA 21 0181023

(3R,4S)-3-Ethyl-4-(3-(hydroxymethyl)-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide


  • Catalogue No.:PA 21 0181023

  • CAS :

    NA

  • Molecular Formula : C18H21F3N6O2

  • Molecular Weight : 410.4

stdClass Object
(
    [pname] => 1-((3S,4R)-3-Ethyl-4-(3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)pyrrolidin-1-yl)-3,3,3-trifluoropropan-1-one
    [catalogue_number] => PA 21 0181024
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 519.54
    [form] => C24H24F3N5O3S
    [cas] => NA
    [pslug] => 1-3s-4r-3-ethyl-4-3-tosyl-3h-imidazo-1-2-a-pyrrolo-2-3-e-pyrazin-8-yl-pyrrolidin-1-yl-3-3-3-trifluoropropan-1-one-pa210181024
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PA 21 0181024

1-((3S,4R)-3-Ethyl-4-(3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)pyrrolidin-1-yl)-3,3,3-trifluoropropan-1-one


  • Catalogue No.:PA 21 0181024

  • CAS :

    NA

  • Molecular Formula : C24H24F3N5O3S

  • Molecular Weight : 519.54