A multikinase inhibitor, Regorafenib is used in the treatment of metastatic colorectal cancer and advanced gastrointestinal stromal tumors. Shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition.Reference standards of Regorafenib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
stdClass Object ( [pname] => Regorafenib N-Oxide [catalogue_number] => PA 18 49510 [category_ids] => ,79,80,71,76,75,78,70,82, [chemical_name] => [weight] => 498.81 [form] => C21H15ClF4N4O4 [cas] => 835621-11-9 [pslug] => 835621-11-9-regorafenib-n-oxide-pa1849510 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 18 49510
CAS :
Molecular Formula : C21H15ClF4N4O4
Molecular Weight : 498.81
stdClass Object ( [pname] => 4-(4-Amino-3-fluorophenoxy)-N-(2-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)picolinamide [catalogue_number] => PA 18 49520 [category_ids] => ,79,80,71,76,75,78,70,82,89, [chemical_name] => [weight] => 491.45 [form] => C25H19F2N5O4 [cas] => 2518234-85-8 [pslug] => 2518234-85-8-4-4-amino-3-fluorophenoxy-n-2-fluoro-4-2-methylcarbamoyl-pyridin-4-yl-oxy-phenyl-picolinamide-pa1849520 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 18 49520
Molecular Formula : C25H19F2N5O4
Molecular Weight : 491.45
stdClass Object ( [pname] => Hydroxyregorafenib [catalogue_number] => PA 18 49530 [category_ids] => ,79,80,71,76,75,78,70,82, [chemical_name] => [weight] => 498.81 [form] => C21H15ClF4N4O4 [cas] => 1343498-71-4 [pslug] => 1343498-71-4-hydroxyregorafenib-pa1849530 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 18 49530
stdClass Object ( [pname] => N-Desmethyl Regorafenib [catalogue_number] => PA 18 49580 [category_ids] => 82,80,79,78,76,75,71,70 [chemical_name] => [weight] => 468.79 [form] => C20H13ClF4N4O3 [cas] => 1343498-72-5 [pslug] => 1343498-72-5-n-desmethyl-regorafenib-pa1849580 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 18 49580
Molecular Formula : C20H13ClF4N4O3
Molecular Weight : 468.79
stdClass Object ( [pname] => Regorafenib Tablets EP Impurity FP-A [catalogue_number] => PA 18 49630 [category_ids] => ,80,71,76,75,78,70,82, [chemical_name] => [weight] => 333.31 [form] => C16H16FN3O4 [cas] => 2514957-39-0 [pslug] => 2514957-39-0-regorafenib-tablets-ep-impurity-fp-a-pa1849630 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 18 49630
Molecular Formula : C16H16FN3O4
Molecular Weight : 333.31
stdClass Object ( [pname] => Regorafenib - Impurity E [catalogue_number] => PA 18 0490050 [category_ids] => ,78,75,76,82, [chemical_name] => [weight] => 811.49 [form] => C35H23Cl2F7N6O5 [cas] => 2098799-13-2 [pslug] => 2098799-13-2-regorafenib-impurity-e-pa180490050 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 18 0490050
Molecular Formula : C35H23Cl2F7N6O5
Molecular Weight : 811.49
stdClass Object ( [pname] => N-Desmethyl Regorafenib N-Oxide (M5 Metabolite) [catalogue_number] => PA 18 0491000 [category_ids] => ,75,76,78,70,82, [chemical_name] => [weight] => 484.79 [form] => C20H13ClF4N4O4 [cas] => 835621-12-0 [pslug] => 835621-12-0-n-desmethyl-regorafenib-n-oxide-m5-metabolite-pa180491000 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 18 0491000
Molecular Formula : C20H13ClF4N4O4
Molecular Weight : 484.79
stdClass Object ( [pname] => 4-(3-Fluoro-4-(3-(3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide [catalogue_number] => PA 18 0491001 [category_ids] => ,75,76,78,70,82, [chemical_name] => [weight] => 448.38 [form] => C21H16F4N4O3 [cas] => 2188236-16-8 [pslug] => 2188236-16-8-4-3-fluoro-4-3-3-trifluoromethyl-phenyl-ureido-phenoxy-n-methylpicolinamide-pa180491001 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 18 0491001
Molecular Formula : C21H16F4N4O3
Molecular Weight : 448.38
stdClass Object ( [pname] => 4-(4-acetamido-3-fluorophenoxy)-N-methylpicolinamide [catalogue_number] => PA 18 0491002 [category_ids] => ,75,76,78,70,82, [chemical_name] => [weight] => 303.29 [form] => C15H14FN3O3 [cas] => 2141961-84-2 [pslug] => 2141961-84-2-4-4-acetamido-3-fluorophenoxy-n-methylpicolinamide-pa180491002 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 18 0491002
Molecular Formula : C15H14FN3O3
Molecular Weight : 303.29
stdClass Object ( [pname] => Regorafenib D3 [catalogue_number] => PA STI 089099 [category_ids] => ,98,75,76,78,70,82, [chemical_name] => [weight] => 485.84 [form] => C21H12D3ClF4N4O3 [cas] => 1255386-16-3 [pslug] => 1255386-16-3-regorafenib-d3-pasti089099 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA STI 089099
Molecular Formula : C21H12D3ClF4N4O3
Molecular Weight : 485.84
stdClass Object ( [pname] => Regorafenib 13CD3 [catalogue_number] => PA STI 089168 [category_ids] => ,98,75,76,78,70,82, [chemical_name] => [weight] => 486.83 [form] => C2013CH12D3ClF4N4O3 [cas] => 2126178-55-8 [pslug] => 2126178-55-8-regorafenib-13cd3-pasti089168 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA STI 089168
Molecular Formula : C2013CH12D3ClF4N4O3
Molecular Weight : 486.83
stdClass Object ( [pname] => Regorafenib 13CD3 N-Oxide [catalogue_number] => PA STI 089169 [category_ids] => ,98,75,76,78,70,82, [chemical_name] => [weight] => 502.83 [form] => C2013CH12D3ClF4N4O4 [cas] => 2140317-01-5 [pslug] => 2140317-01-5-regorafenib-13cd3-n-oxide-pasti089169 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA STI 089169
Molecular Formula : C2013CH12D3ClF4N4O4
Molecular Weight : 502.83
stdClass Object ( [pname] => Regorafenib Dipyrimidine Impurity [catalogue_number] => PA 18 0491003 [category_ids] => ,75,76,78,70,82, [chemical_name] => [weight] => 380.38 [form] => C20H17FN4O3 [cas] => NA [pslug] => regorafenib-dipyrimidine-impurity-pa180491003 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 18 0491003
Molecular Formula : C20H17FN4O3
Molecular Weight : 380.38
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