Alvimopan-Impurities | Pharmaffiliates

alvimopan

Alvimopan is used to avoid postoperative ileus following small or large bowel resection and accelerates the gastrointestinal recovery period.It is a peripherally acting μ opioid antagonist. Reference standards of Alvimopan API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

stdClass Object
(
    [pname] => 2-((R)-2-Benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanamido)acetic Acid
    [catalogue_number] => PA 28 13620
    [category_ids] => ,70,82,76,
    [chemical_name] => 
    [weight] => 424.53
    [form] => C25H32N2O4
    [cas] => 342639-35-4
    [pslug] => 342639-35-4-2-r-2-benzyl-3-3r-4r-4-3-hydroxyphenyl-3-4-dimethylpiperidin-1-yl-propanamido-acetic-acid-pa2813620
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PA 28 13620

2-((R)-2-Benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanamido)acetic Acid


  • Catalogue No.:PA 28 13620

  • CAS :

    342639-35-4

  • Molecular Formula : C25H32N2O4

  • Molecular Weight : 424.53

stdClass Object
(
    [pname] => Alvimopan Acyl-β-D-glucuronide
    [catalogue_number] => PA 28 13690
    [category_ids] => ,80,69,95,76,75,78,70,82,
    [chemical_name] => 
    [weight] => 600.66
    [form] => C31H40N2O10
    [cas] => 1260616-95-2
    [pslug] => 1260616-95-2-alvimopan-acyl-beta-d-glucuronide-pa2813690
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PA 28 13690

Alvimopan Acyl-β-D-glucuronide


  • Catalogue No.:PA 28 13690

  • CAS :

    1260616-95-2

  • Molecular Formula : C31H40N2O10

  • Molecular Weight : 600.66

stdClass Object
(
    [pname] => tert-Butyl 3-Methyl-4-oxopiperidine-1-carboxylate
    [catalogue_number] => PAI 28 013001
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 213.28
    [form] => C11H19NO3
    [cas] => 181269-69-2
    [pslug] => 181269-69-2-tert-butyl-3-methyl-4-oxopiperidine-1-carboxylate-pai28013001
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PAI 28 013001

tert-Butyl 3-Methyl-4-oxopiperidine-1-carboxylate


  • Catalogue No.:PAI 28 013001

  • CAS :

    181269-69-2

  • Molecular Formula : C11H19NO3

  • Molecular Weight : 213.28

stdClass Object
(
    [pname] => tert-Butyl 4-hydroxy-4-(3-methoxyphenyl)-3-methylpiperidine-1-carboxylate
    [catalogue_number] => PAI 28 013002
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 321.42
    [form] => C18H27NO4
    [cas] => NA
    [pslug] => -tert-butyl-4-hydroxy-4-3-methoxyphenyl-3-methylpiperidine-1-carboxylate-pai28013002
    [latest_product] => 0
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PAI 28 013002

tert-Butyl 4-hydroxy-4-(3-methoxyphenyl)-3-methylpiperidine-1-carboxylate


  • Catalogue No.:PAI 28 013002

  • CAS :

    NA

  • Molecular Formula : C18H27NO4

  • Molecular Weight : 321.42

stdClass Object
(
    [pname] => tert-Butyl 4-bromo-4-(3-methoxyphenyl)-3-methylpiperidine-1-carboxylate
    [catalogue_number] => PAI 28 013003
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 384.31
    [form] => C18H26BrNO3
    [cas] => NA
    [pslug] => -tert-butyl-4-bromo-4-3-methoxyphenyl-3-methylpiperidine-1-carboxylate-pai28013003
    [latest_product] => 0
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PAI 28 013003

tert-Butyl 4-bromo-4-(3-methoxyphenyl)-3-methylpiperidine-1-carboxylate


  • Catalogue No.:PAI 28 013003

  • CAS :

    NA

  • Molecular Formula : C18H26BrNO3

  • Molecular Weight : 384.31

stdClass Object
(
    [pname] => tert-Butyl 4-(3-methoxyphenyl)-3,4-dimethylpiperidine-1-carboxylate
    [catalogue_number] => PAI 28 013004
    [category_ids] => ,78,75,70,76,82,
    [chemical_name] => 
    [weight] => 319.45
    [form] => C19H29NO3
    [cas] => NA
    [pslug] => -tert-butyl-4-3-methoxyphenyl-3-4-dimethylpiperidine-1-carboxylate-pai28013004
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PAI 28 013004

tert-Butyl 4-(3-methoxyphenyl)-3,4-dimethylpiperidine-1-carboxylate


  • Catalogue No.:PAI 28 013004

  • CAS :

    NA

  • Molecular Formula : C19H29NO3

  • Molecular Weight : 319.45

stdClass Object
(
    [pname] => (alphaS,3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethyl-alpha-(phenylmethyl)-1-piperidinepropanoic acid methyl ester
    [catalogue_number] => PA 28 0131000
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 381.52
    [form] => C24H31NO3
    [cas] => 170098-29-0
    [pslug] => 170098-29-0-alphas-3r-4r-4-3-hydroxyphenyl-3-4-dimethyl-alpha-phenylmethyl-1-piperidinepropanoic-acid-methyl-ester-pa280131000
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PA 28 0131000

(alphaS,3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethyl-alpha-(phenylmethyl)-1-piperidinepropanoic acid methyl ester


  • Catalogue No.:PA 28 0131000

  • CAS :

    170098-29-0

  • Molecular Formula : C24H31NO3

  • Molecular Weight : 381.52

stdClass Object
(
    [pname] => N-[1-Oxo-2-(phenylmethyl)-2-propenyl]glycine
    [catalogue_number] => PA 28 0131001
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 219.24
    [form] => C12H13NO3
    [cas] => 76932-18-8
    [pslug] => 76932-18-8-n-1-oxo-2-phenylmethyl-2-propenyl-glycine-pa280131001
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PA 28 0131001

N-[1-Oxo-2-(phenylmethyl)-2-propenyl]glycine


  • Catalogue No.:PA 28 0131001

  • CAS :

    76932-18-8

  • Molecular Formula : C12H13NO3

  • Molecular Weight : 219.24

stdClass Object
(
    [pname] => ((2S)-2-Benzyl-3-((3R)-4-(3-hydroxyphenyl)-3-methylpiperidin-1-yl)propanoyl)glycine
    [catalogue_number] => PA 28 0131002
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 416.56
    [form] => C24H36N2O4
    [cas] => NA
    [pslug] => 2s-2-benzyl-3-3r-4-3-hydroxyphenyl-3-methylpiperidin-1-yl-propanoyl-glycine-pa280131002
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PA 28 0131002

((2S)-2-Benzyl-3-((3R)-4-(3-hydroxyphenyl)-3-methylpiperidin-1-yl)propanoyl)glycine


  • Catalogue No.:PA 28 0131002

  • CAS :

    NA

  • Molecular Formula : C24H36N2O4

  • Molecular Weight : 416.56

stdClass Object
(
    [pname] => Ethyl ((S)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanoyl)glycinate hydrochloride
    [catalogue_number] => PA 28 0131003
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 489.05
    [form] => C27H37ClN2O4
    [cas] => 1314751-88-6
    [pslug] => 1314751-88-6-ethyl-s-2-benzyl-3-3r-4r-4-3-hydroxyphenyl-3-4-dimethylpiperidin-1-yl-propanoyl-glycinate-hydrochloride-pa280131003
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PA 28 0131003

Ethyl ((S)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanoyl)glycinate hydrochloride


  • Catalogue No.:PA 28 0131003

  • CAS :

    1314751-88-6

  • Molecular Formula : C27H37ClN2O4

  • Molecular Weight : 489.05

stdClass Object
(
    [pname] => ((S)-2-Benzyl-3-((3R,4R)-3,4-dimethyl-4-(3-(sulfooxy)phenyl)piperidin-1-yl)propanoyl)glycine
    [catalogue_number] => PA 28 0131004
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 504.6
    [form] => C25H32N2O7S
    [cas] => NA
    [pslug] => s-2-benzyl-3-3r-4r-3-4-dimethyl-4-3-sulfooxy-phenyl-piperidin-1-yl-propanoyl-glycine-pa280131004
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PA 28 0131004

((S)-2-Benzyl-3-((3R,4R)-3,4-dimethyl-4-(3-(sulfooxy)phenyl)piperidin-1-yl)propanoyl)glycine


  • Catalogue No.:PA 28 0131004

  • CAS :

    NA

  • Molecular Formula : C25H32N2O7S

  • Molecular Weight : 504.6

stdClass Object
(
    [pname] => Methyl (Z)-2-(((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)methyl)-3-phenylacrylate hydrochloride
    [catalogue_number] => PA 28 0131005
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 415.96
    [form] => C24H30ClNO3
    [cas] => 1420776-96-0
    [pslug] => 1420776-96-0-methyl-z-2-3r-4r-4-3-hydroxyphenyl-3-4-dimethylpiperidin-1-yl-methyl-3-phenylacrylate-hydrochloride-pa280131005
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PA 28 0131005

Methyl (Z)-2-(((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)methyl)-3-phenylacrylate hydrochloride


  • Catalogue No.:PA 28 0131005

  • CAS :

    1420776-96-0

  • Molecular Formula : C24H30ClNO3

  • Molecular Weight : 415.96

stdClass Object
(
    [pname] => Ethyl ((S)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanoyl)glycinate
    [catalogue_number] => PA 28 0131006
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 452.6
    [form] => C27H36N2O4
    [cas] => 660848-91-9
    [pslug] => 660848-91-9-ethyl-s-2-benzyl-3-3r-4r-4-3-hydroxyphenyl-3-4-dimethylpiperidin-1-yl-propanoyl-glycinate-pa280131006
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PA 28 0131006

Ethyl ((S)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanoyl)glycinate


  • Catalogue No.:PA 28 0131006

  • CAS :

    660848-91-9

  • Molecular Formula : C27H36N2O4

  • Molecular Weight : 452.6

stdClass Object
(
    [pname] => 3-(1,3,6-Trimethyl-1,2,3,6-tetrahydropyridin-4-yl)phenol
    [catalogue_number] => PA 28 0131007
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 217.31
    [form] => C14H19NO
    [cas] => 2806204-96-4
    [pslug] => 2806204-96-4-3-1-3-6-trimethyl-1-2-3-6-tetrahydropyridin-4-yl-phenol-pa280131007
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PA 28 0131007

3-(1,3,6-Trimethyl-1,2,3,6-tetrahydropyridin-4-yl)phenol


  • Catalogue No.:PA 28 0131007

  • CAS :

    2806204-96-4

  • Molecular Formula : C14H19NO

  • Molecular Weight : 217.31

stdClass Object
(
    [pname] => 3-(1,3,5-Trimethyl-1,2,3,6-tetrahydropyridin-4-yl)phenol
    [catalogue_number] => PA 28 0131008
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 217.31
    [form] => C14H19NO
    [cas] => 2837855-90-8
    [pslug] => 2837855-90-8-3-1-3-5-trimethyl-1-2-3-6-tetrahydropyridin-4-yl-phenol-pa280131008
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PA 28 0131008

3-(1,3,5-Trimethyl-1,2,3,6-tetrahydropyridin-4-yl)phenol


  • Catalogue No.:PA 28 0131008

  • CAS :

    2837855-90-8

  • Molecular Formula : C14H19NO

  • Molecular Weight : 217.31

stdClass Object
(
    [pname] => Methyl ((R)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanoyl)glycinate
    [catalogue_number] => PA 28 0131009
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 438.57
    [form] => C26H34N2O4
    [cas] => NA
    [pslug] => methyl-r-2-benzyl-3-3r-4r-4-3-hydroxyphenyl-3-4-dimethylpiperidin-1-yl-propanoyl-glycinate-pa280131009
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PA 28 0131009

Methyl ((R)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanoyl)glycinate


  • Catalogue No.:PA 28 0131009

  • CAS :

    NA

  • Molecular Formula : C26H34N2O4

  • Molecular Weight : 438.57

stdClass Object
(
    [pname] => Methyl (R)-(2-benzyl-3-hydroxypropanoyl)glycinate
    [catalogue_number] => PA 28 0131010
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 251.28
    [form] => C13H17NO4
    [cas] => NA
    [pslug] => methyl-r-2-benzyl-3-hydroxypropanoyl-glycinate-pa280131010
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PA 28 0131010

Methyl (R)-(2-benzyl-3-hydroxypropanoyl)glycinate


  • Catalogue No.:PA 28 0131010

  • CAS :

    NA

  • Molecular Formula : C13H17NO4

  • Molecular Weight : 251.28

stdClass Object
(
    [pname] => Alvimopan D7
    [catalogue_number] => PA STI 088912
    [category_ids] => ,98,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 431.58
    [form] =>  C25H25D7N2O4
    [cas] => 1261396-48-8
    [pslug] => 1261396-48-8-alvimopan-d7-pasti088912
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PA STI 088912

Alvimopan D7


  • Catalogue No.:PA STI 088912

  • CAS :

    1261396-48-8

  • Molecular Formula : C25H25D7N2O4

  • Molecular Weight : 431.58

stdClass Object
(
    [pname] => Alvimopan Desmethyl Impurity
    [catalogue_number] => PA 28 0131011
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 410.51
    [form] => C24H30N2O4
    [cas] => NA
    [pslug] => alvimopan-desmethyl-impurity-pa280131011
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PA 28 0131011

Alvimopan Desmethyl Impurity


  • Catalogue No.:PA 28 0131011

  • CAS :

    NA

  • Molecular Formula : C24H30N2O4

  • Molecular Weight : 410.51

stdClass Object
(
    [pname] =>  Methyl (R)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanoate Hydrochloride
    [catalogue_number] => PA 28 0131012
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 417.97
    [form] => C24H32ClNO3
    [cas] => 170098-42-7
    [pslug] => 170098-42-7-methyl-r-2-benzyl-3-3r-4r-4-3-hydroxyphenyl-3-4-dimethylpiperidin-1-yl-propanoate-hydrochloride-pa280131012
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PA 28 0131012

 Methyl (R)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanoate Hydrochloride


  • Catalogue No.:PA 28 0131012

  • CAS :

    170098-42-7

  • Molecular Formula : C24H32ClNO3

  • Molecular Weight : 417.97

stdClass Object
(
    [pname] =>  3-(1,3,3-Trimethyl-1,2,3,6-tetrahydropyridin-4-yl)phenol
    [catalogue_number] => PA 28 0131013
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 217.31
    [form] => C14H19NO
    [cas] => 2250243-53-7
    [pslug] => 2250243-53-7-3-1-3-3-trimethyl-1-2-3-6-tetrahydropyridin-4-yl-phenol-pa280131013
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PA 28 0131013

 3-(1,3,3-Trimethyl-1,2,3,6-tetrahydropyridin-4-yl)phenol


  • Catalogue No.:PA 28 0131013

  • CAS :

    2250243-53-7

  • Molecular Formula : C14H19NO

  • Molecular Weight : 217.31

stdClass Object
(
    [pname] =>  4-(3-Isopropoxyphenyl)-1,3,4-trimethyl-1,2,3,4-tetrahydropyridine
    [catalogue_number] => PA 28 0131014
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 259.39
    [form] => C17H25NO
    [cas] => 145340-45-0
    [pslug] => 145340-45-0-4-3-isopropoxyphenyl-1-3-4-trimethyl-1-2-3-4-tetrahydropyridine-pa280131014
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PA 28 0131014

 4-(3-Isopropoxyphenyl)-1,3,4-trimethyl-1,2,3,4-tetrahydropyridine


  • Catalogue No.:PA 28 0131014

  • CAS :

    145340-45-0

  • Molecular Formula : C17H25NO

  • Molecular Weight : 259.39

stdClass Object
(
    [pname] =>  Ethyl-2-[(2S)-2-benzyl-3-Hydroxy propanamido]acetate
    [catalogue_number] => PA 28 0131016
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 265.31
    [form] => C14H19NO4
    [cas] => 1314751-83-1
    [pslug] => 1314751-83-1-ethyl-2-2s-2-benzyl-3-hydroxy-propanamido-acetate-pa280131016
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PA 28 0131016

 Ethyl-2-[(2S)-2-benzyl-3-Hydroxy propanamido]acetate


  • Catalogue No.:PA 28 0131016

  • CAS :

    1314751-83-1

  • Molecular Formula : C14H19NO4

  • Molecular Weight : 265.31

stdClass Object
(
    [pname] => (S)-2-Benzyl-3-(benzyloxy)Propanoic Acid
    [catalogue_number] => PA 28 0131015
    [category_ids] => ,75,76,78,70,82,
    [chemical_name] => 
    [weight] => 270.33
    [form] => C17H18O3
    [cas] => 1237735-54-4
    [pslug] => 1237735-54-4-s-2-benzyl-3-benzyloxy-propanoic-acid-pa280131015
    [latest_product] => 0
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PA 28 0131015

(S)-2-Benzyl-3-(benzyloxy)Propanoic Acid


  • Catalogue No.:PA 28 0131015

  • CAS :

    1237735-54-4

  • Molecular Formula : C17H18O3

  • Molecular Weight : 270.33