trametinib
Trametinib may be used alone or in combination with another medication to treat a type of skin cancer. It is a MEK inhibitor drug with anti-cancer activity.Reference standards of Trametinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
stdClass Object
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[pname] => Trametinib
[catalogue_number] => PA 47 14000
[category_ids] => ,80,78,70,82,
[chemical_name] =>
[weight] => 615.39
[form] => C26H23FIN5O4
[cas] => 871700-17-3
[pslug] => 871700-17-3-trametinib-api-pa4714000
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Catalogue No.:PA 47 14000
Molecular Formula : C26H23FIN5O4
Molecular Weight : 615.39
stdClass Object
(
[pname] => N-(3-(5-((4-Bromo-2-fluorophenyl)amino)-3-cyclopropyl-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
[catalogue_number] => PA 47 14510
[category_ids] => ,80,78,70,82,79,89,
[chemical_name] =>
[weight] => 568.39
[form] => C26H23BrFN5O4
[cas] => 871700-13-9
[pslug] => 871700-13-9-n-3-5-4-bromo-2-fluorophenyl-amino-3-cyclopropyl-6-8-dimethyl-2-4-7-trioxo-3-4-6-7-tetrahydropyrido-4-3-d-pyrimidin-1-2h-yl-phenyl-acetamide-pa4714510
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N-(3-(5-((4-Bromo-2-fluorophenyl)amino)-3-cyclopropyl-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
Catalogue No.:PA 47 14510
Molecular Formula : C26H23BrFN5O4
Molecular Weight : 568.39
stdClass Object
(
[pname] => 3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione
[catalogue_number] => PA 47 14520
[category_ids] => ,78,70,82,89,79,80,
[chemical_name] =>
[weight] => 401.17
[form] => C14H13FIN3O2
[cas] => 871700-22-0
[pslug] => 871700-22-0-3-cyclopropyl-1-2-fluoro-4-iodophenyl-6-methylamino-pyrimidine-2-4-1h-3h-dione-pa4714520
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3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione
Catalogue No.:PA 47 14520
Molecular Formula : C14H13FIN3O2
Molecular Weight : 401.17
stdClass Object
(
[pname] => Trametinib-d4
[catalogue_number] => PA STI 084082
[category_ids] => ,79,80,71,78,70,82,98,
[chemical_name] =>
[weight] => 619.42
[form] => C26H19D4FIN5O4
[cas] => NA
[pslug] => trametinib-d4-pasti084082
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Catalogue No.:PA STI 084082
Molecular Formula : C26H19D4FIN5O4
Molecular Weight : 619.42
stdClass Object
(
[pname] => Trametinib Dimethyl Sulfoxide
[catalogue_number] => PA 47 0141000
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 693.53
[form] => C28H29FIN5O5S
[cas] => 1187431-43-1
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Trametinib Dimethyl Sulfoxide
Catalogue No.:PA 47 0141000
Molecular Formula : C28H29FIN5O5S
Molecular Weight : 693.53
stdClass Object
(
[pname] => 1-(3-Aminophenyl)-3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione
[catalogue_number] => PA 47 0141001
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 573.37
[form] => C24H21FIN5O3
[cas] => 871701-87-0
[pslug] => 871701-87-0-1-3-aminophenyl-3-cyclopropyl-5-2-fluoro-4-iodophenyl-amino-6-8-dimethylpyrido-4-3-d-pyrimidine-2-4-7-1h-3h-6h-trione-pa470141001
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1-(3-Aminophenyl)-3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione
Catalogue No.:PA 47 0141001
Molecular Formula : C24H21FIN5O3
Molecular Weight : 573.37
stdClass Object
(
[pname] => 1-(3-Amino-4-hydroxyphenyl)-3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione
[catalogue_number] => PA 47 0141002
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[weight] => 589.37
[form] => C24H21FIN5O4
[cas] => 1620017-29-9
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1-(3-Amino-4-hydroxyphenyl)-3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione
Catalogue No.:PA 47 0141002
Molecular Formula : C24H21FIN5O4
Molecular Weight : 589.37
stdClass Object
(
[pname] => 3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7(1H,3H,8H)-trione
[catalogue_number] => PA 47 0141005
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[weight] => 483.24
[form] => C18H15FIN3O4
[cas] => 871700-24-2
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3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7(1H,3H,8H)-trione
Catalogue No.:PA 47 0141005
Molecular Formula : C18H15FIN3O4
Molecular Weight : 483.24
stdClass Object
(
[pname] => N-(3-((3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl)amino)phenyl)acetamide
[catalogue_number] => PA 47 0141004
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[weight] => 615.4
[form] => C26H23FIN5O4
[cas] => 871700-25-3
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N-(3-((3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl)amino)phenyl)acetamide
stdClass Object
(
[pname] => Desiodo Trametinib
[catalogue_number] => PA 47 0141003
[category_ids] => ,80,78,70,82,76,
[chemical_name] =>
[weight] => 489.51
[form] => C26H24FN5O4
[cas] => 871700-65-1
[pslug] => 871700-65-1-desiodo-trametinib-pa470141003
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Catalogue No.:PA 47 0141003
Molecular Formula : C26H24FN5O4
Molecular Weight : 489.51
stdClass Object
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[pname] => N-Cyclopropyl-2-((2-fluoro-4-iodophenyl)amino)-4-hydroxy-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
[catalogue_number] => PA 47 0141006
[category_ids] => ,78,70,82,
[chemical_name] =>
[weight] => 457.24
[form] => C17H17FIN3O3
[cas] => 3018911-27-5
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N-Cyclopropyl-2-((2-fluoro-4-iodophenyl)amino)-4-hydroxy-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
Catalogue No.:PA 47 0141006
Molecular Formula : C17H17FIN3O3
Molecular Weight : 457.24
stdClass Object
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[pname] => N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)imino)-8-hydroxy-6,8-dimethyl-2,4,7-trioxo-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
[catalogue_number] => PA 47 0141007
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[chemical_name] =>
[weight] => 631.4
[form] => C26H23FIN5O5
[cas] => 1383430-03-2
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N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)imino)-8-hydroxy-6,8-dimethyl-2,4,7-trioxo-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
stdClass Object
(
[pname] => N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)imino)-8-hydroperoxy-6,8-dimethyl-2,4,7-trioxo-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
[catalogue_number] => PA 47 0141008
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[weight] => 647.4
[form] => C26H23FIN5O6
[cas] => 1383430-04-3
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N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)imino)-8-hydroperoxy-6,8-dimethyl-2,4,7-trioxo-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
stdClass Object
(
[pname] => 3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-1-(3-nitrophenyl)pyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione
[catalogue_number] => PA 47 0141009
[category_ids] => ,80,78,70,82,
[chemical_name] =>
[weight] => 603.35
[form] => C24H19FIN5O5
[cas] => 1279693-89-8
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3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-1-(3-nitrophenyl)pyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione
Catalogue No.:PA 47 0141009
Molecular Formula : C24H19FIN5O5
Molecular Weight : 603.35
stdClass Object
(
[pname] => N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)(nitroso)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
[catalogue_number] => PA 47 0141010
[category_ids] => ,80,78,70,82,
[chemical_name] =>
[weight] => 644.4
[form] => C26H22FIN6O5
[cas] => NA
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N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)(nitroso)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
stdClass Object
(
[pname] => N-(1-Cyclopropyl-3-(2-fluoro-4-iodophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-N-methylnitrous amide
[catalogue_number] => PA 47 0141011
[category_ids] => ,80,78,70,82,
[chemical_name] =>
[weight] => 430.18
[form] => C14H12FIN4O3
[cas] => NA
[pslug] => n-1-cyclopropyl-3-2-fluoro-4-iodophenyl-2-6-dioxo-1-2-3-6-tetrahydropyrimidin-4-yl-n-methylnitrous-amide-pa470141011
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N-(1-Cyclopropyl-3-(2-fluoro-4-iodophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-N-methylnitrous amide
Catalogue No.:PA 47 0141011
Molecular Formula : C14H12FIN4O3
Molecular Weight : 430.18
stdClass Object
(
[pname] => N-(3-((3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl)(nitroso)amino)phenyl)acetamide
[catalogue_number] => PA 47 0141012
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[weight] => 644.4
[form] => C26H22FIN6O5
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N-(3-((3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl)(nitroso)amino)phenyl)acetamide
stdClass Object
(
[pname] => 4-((3-Acetamidophenyl)amino)-N-cyclopropyl-2-((2-fluoro-4-iodophenyl)amino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
[catalogue_number] => PA 47 0141013
[category_ids] => ,80,78,70,82,
[chemical_name] =>
[weight] => 589.41
[form] => C25H25FIN5O3
[cas] => NA
[pslug] => 4-3-acetamidophenyl-amino-n-cyclopropyl-2-2-fluoro-4-iodophenyl-amino-1-5-dimethyl-6-oxo-1-6-dihydropyridine-3-carboxamide-pa470141013
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4-((3-Acetamidophenyl)amino)-N-cyclopropyl-2-((2-fluoro-4-iodophenyl)amino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
Catalogue No.:PA 47 0141013
Molecular Formula : C25H25FIN5O3
Molecular Weight : 589.41
stdClass Object
(
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[catalogue_number] => PA 47 0141014
[category_ids] => ,80,78,70,82,
[chemical_name] =>
[weight] => 623.43
[form] => C28H23FIN5O3
[cas] => NA
[pslug] => 3-cyclopropyl-5-2-fluoro-4-iodophenyl-amino-6-8-dimethyl-1-2-methylquinolin-7-yl-pyrido-4-3-d-pyrimidine-2-4-7-1h-3h-6h-trione-pa470141014
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3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-1-(2-methylquinolin-7-yl)pyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione
Catalogue No.:PA 47 0141014
Molecular Formula : C28H23FIN5O3
Molecular Weight : 623.43
stdClass Object
(
[pname] => 3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate
[catalogue_number] => PA 47 0141015
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[weight] => 637.42
[form] => C25H21FIN3O6S
[cas] => 871700-32-2
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3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate
Catalogue No.:PA 47 0141015
Molecular Formula : C25H21FIN3O6S
Molecular Weight : 637.42
stdClass Object
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[pname] => 3'-Aminoacetanilide
[catalogue_number] => PA 47 0141016
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[chemical_name] =>
[weight] => 150.18
[form] => C8H10N2O
[cas] => 102-28-3
[pslug] => 102-28-3-3-aminoacetanilide-pa470141016
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Catalogue No.:PA 47 0141016
Molecular Formula : C8H10N2O
Molecular Weight : 150.18
stdClass Object
(
[pname] => N,N'-(1,3-Phenylene)diacetamide
[catalogue_number] => PA 47 0141017
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[chemical_name] =>
[weight] => 192.22
[form] => C10H12N2O2
[cas] => 10268-78-7
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N,N'-(1,3-Phenylene)diacetamide
Catalogue No.:PA 47 0141017
Molecular Formula : C10H12N2O2
Molecular Weight : 192.22
stdClass Object
(
[pname] => N'-(1-Cyclopropyl-3-(2-fluoro-4-iodophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-N,N-dimethylformimidamide
[catalogue_number] => PA 47 0141018
[category_ids] => ,80,78,70,82,
[chemical_name] =>
[weight] => 442.23
[form] => C16H16FIN4O2
[cas] => 871700-30-0
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N'-(1-Cyclopropyl-3-(2-fluoro-4-iodophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-N,N-dimethylformimidamide
Catalogue No.:PA 47 0141018
Molecular Formula : C16H16FIN4O2
Molecular Weight : 442.23
stdClass Object
(
[pname] => N-(3-(3-Cyclopropyl-5-((2-fluorophenyl)(nitroso)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
[catalogue_number] => PA 47 0141019
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[chemical_name] =>
[weight] => 518.51
[form] => C26H23FN6O5
[cas] => NA
[pslug] => n-3-3-cyclopropyl-5-2-fluorophenyl-nitroso-amino-6-8-dimethyl-2-4-7-trioxo-3-4-6-7-tetrahydropyrido-4-3-d-pyrimidin-1-2h-yl-phenyl-acetamide-pa470141019
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N-(3-(3-Cyclopropyl-5-((2-fluorophenyl)(nitroso)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
Catalogue No.:PA 47 0141019
Molecular Formula : C26H23FN6O5
Molecular Weight : 518.51
stdClass Object
(
[pname] => N-(1-(3-Aminophenyl)-3-cyclopropyl-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,6,7-hexahydropyrido[4,3-d]pyrimidin-5-yl)-N-(2-fluoro-4-iodophenyl)nitrous amide
[catalogue_number] => PA 47 0141020
[category_ids] => ,80,78,70,82,162,
[chemical_name] =>
[weight] => 602.36
[form] => C24H20FIN6O4
[cas] => NA
[pslug] => n-1-3-aminophenyl-3-cyclopropyl-6-8-dimethyl-2-4-7-trioxo-1-2-3-4-6-7-hexahydropyrido-4-3-d-pyrimidin-5-yl-n-2-fluoro-4-iodophenyl-nitrous-amide-pa470141020
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N-(1-(3-Aminophenyl)-3-cyclopropyl-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,6,7-hexahydropyrido[4,3-d]pyrimidin-5-yl)-N-(2-fluoro-4-iodophenyl)nitrous amide
Catalogue No.:PA 47 0141020
Molecular Formula : C24H20FIN6O4
Molecular Weight : 602.36
stdClass Object
(
[pname] => 4-((3-Acetamidophenyl)amino)-N-cyclopropyl-2-((2-fluoro-4-iodophenyl)(nitroso)amino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
[catalogue_number] => PA 47 0141021
[category_ids] => ,80,78,70,82,162,
[chemical_name] =>
[weight] => 618.41
[form] => C25H24FIN6O4
[cas] => NA
[pslug] => 4-3-acetamidophenyl-amino-n-cyclopropyl-2-2-fluoro-4-iodophenyl-nitroso-amino-1-5-dimethyl-6-oxo-1-6-dihydropyridine-3-carboxamide-pa470141021
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4-((3-Acetamidophenyl)amino)-N-cyclopropyl-2-((2-fluoro-4-iodophenyl)(nitroso)amino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
Catalogue No.:PA 47 0141021
Molecular Formula : C25H24FIN6O4
Molecular Weight : 618.41
stdClass Object
(
[pname] => 4-((3-Acetamidophenyl)(nitroso)amino)-N-cyclopropyl-2-((2-fluoro-4-iodophenyl)(nitroso)amino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
[catalogue_number] => PA 47 0141022
[category_ids] => ,80,78,70,82,162,
[chemical_name] =>
[weight] => 647.41
[form] => C25H23FIN7O5
[cas] => NA
[pslug] => 4-3-acetamidophenyl-nitroso-amino-n-cyclopropyl-2-2-fluoro-4-iodophenyl-nitroso-amino-1-5-dimethyl-6-oxo-1-6-dihydropyridine-3-carboxamide-pa470141022
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4-((3-Acetamidophenyl)(nitroso)amino)-N-cyclopropyl-2-((2-fluoro-4-iodophenyl)(nitroso)amino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
Catalogue No.:PA 47 0141022
Molecular Formula : C25H23FIN7O5
Molecular Weight : 647.41
stdClass Object
(
[pname] => Desacetyl Trametinib N-Glucoronide
[catalogue_number] => PA 47 0141023
[category_ids] => ,80,78,70,82,
[chemical_name] =>
[weight] => 749.49
[form] => C30H29FIN5O9
[cas] => NA
[pslug] => desacetyl-trametinib-n-glucoronide-pa470141023
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Desacetyl Trametinib N-Glucoronide
Catalogue No.:PA 47 0141023
Molecular Formula : C30H29FIN5O9
Molecular Weight : 749.49
stdClass Object
(
[pname] => (2S,3S,4S,5R,6S)-6-(2-Amino-4-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic Acid
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[weight] => 765.49
[form] => C30H29FIN5O10
[cas] => 1620017-28-8
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(2S,3S,4S,5R,6S)-6-(2-Amino-4-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic Acid
Catalogue No.:PA 47 0141024
Molecular Formula : C30H29FIN5O10
Molecular Weight : 765.49