nilotinib
Nilotinib is used to treat Philadelphia chromosome positive chronic myelogenous leukaemia. It is sold under the brand name Tasigna. It is not safe for use during pregnancy. Reference standards of Nilotinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
stdClass Object
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[pname] => 4-Methyl-1-[3-nitro-5-(trifluoromethyl)phenyl]-1H-imidazole
[catalogue_number] => PA 14 64540
[category_ids] => ,80,71,70,78,82,75,79,89,
[chemical_name] =>
[weight] => 271.2
[form] => C11H8F3N3O2
[cas] => 916975-92-3
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4-Methyl-1-[3-nitro-5-(trifluoromethyl)phenyl]-1H-imidazole
stdClass Object
(
[pname] => Nilotinib - Impurity H (Hydrochloride Salt)
[catalogue_number] => PA 14 64550
[category_ids] => ,80,71,70,78,82,75,79,89,
[chemical_name] =>
[weight] => 565.98
[form] => C28H23ClF3N7O
[cas] => NA
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Nilotinib - Impurity H (Hydrochloride Salt)
Catalogue No.:PA 14 64550
Molecular Formula : C28H23ClF3N7O
Molecular Weight : 565.98
stdClass Object
(
[pname] => 3-((4-Chloro-6-(pyridin-3-yl)pyrimidin-2-yl)amino)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide
[catalogue_number] => PA 14 64560
[category_ids] => ,80,71,70,78,82,75,79,89,
[chemical_name] =>
[weight] => 563.96
[form] => C28H21ClF3N7O
[cas] => NA
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3-((4-Chloro-6-(pyridin-3-yl)pyrimidin-2-yl)amino)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide
Catalogue No.:PA 14 64560
Molecular Formula : C28H21ClF3N7O
Molecular Weight : 563.96
stdClass Object
(
[pname] => Nilotinib - Impurity H (Freebase)
[catalogue_number] => PA 14 64570
[category_ids] => ,80,71,70,78,82,75,79,89,
[chemical_name] =>
[weight] => 529.52
[form] => C28H22F3N7O
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Nilotinib - Impurity H (Freebase)
Catalogue No.:PA 14 64570
Molecular Formula : C28H22F3N7O
Molecular Weight : 529.52
stdClass Object
(
[pname] => 3-(4-Ethyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Hydrochloride
[catalogue_number] => PA 14 64580
[category_ids] => ,80,71,70,78,82,75,79,89,
[chemical_name] =>
[weight] => 291.7
[form] => C12H13ClF3N3
[cas] => NA
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3-(4-Ethyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Hydrochloride
stdClass Object
(
[pname] => 3-(1H-Imidazol-1-yl)-5-(trifluoromethyl)aniline
[catalogue_number] => PA 14 64590
[category_ids] => ,80,71,70,78,82,75,79,89,
[chemical_name] =>
[weight] => 227.19
[form] => C10H8F3N3
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3-(1H-Imidazol-1-yl)-5-(trifluoromethyl)aniline
Catalogue No.:PA 14 64590
Molecular Formula : C10H8F3N3
Molecular Weight : 227.19
stdClass Object
(
[pname] => Nilotinib N-Oxide
[catalogue_number] => PA 14 64600
[category_ids] => 85,83,75,76,78,82,71,70,80
[chemical_name] =>
[weight] => 545.53
[form] => C28H22F3N7O2
[cas] => 1246817-85-5
[pslug] => 1246817-85-5-nilotinib-n-oxide-pa1464600
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Catalogue No.:PA 14 64600
Molecular Formula : C28H22F3N7O2
Molecular Weight : 545.53
stdClass Object
(
[pname] => Nilotinib System Suitability Mixture
[catalogue_number] => PA 14 0641001
[category_ids] => ,80,71,76,75,93,78,70,82,
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[weight] => NA
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Nilotinib System Suitability Mixture
stdClass Object
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[pname] => 3-Amino-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide
[catalogue_number] => PA 14 0641002
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[chemical_name] =>
[weight] => 374.37
[form] => C19H17F3N4O
[cas] => 915711-42-1
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3-Amino-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide
Catalogue No.:PA 14 0641002
Molecular Formula : C19H17F3N4O
Molecular Weight : 374.37
stdClass Object
(
[pname] => 3-Iodo-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide
[catalogue_number] => PA 14 0641003
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[chemical_name] =>
[weight] => 485.25
[form] => C19H15F3IN3O
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3-Iodo-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide
Catalogue No.:PA 14 0641003
Molecular Formula : C19H15F3IN3O
Molecular Weight : 485.25
stdClass Object
(
[pname] => 4-(Pyridin-2-yl)pyrimidin-2-amine
[catalogue_number] => PA 14 0641004
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[chemical_name] =>
[weight] => 172.19
[form] => C9H8N4
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4-(Pyridin-2-yl)pyrimidin-2-amine
Catalogue No.:PA 14 0641004
Molecular Formula : C9H8N4
Molecular Weight : 172.19
stdClass Object
(
[pname] => Nilotinib 3-Pyridinyl Impurity
[catalogue_number] => PA 14 0641005
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[weight] => 172.19
[form] => C9H8N4
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Nilotinib 3-Pyridinyl Impurity
Catalogue No.:PA 14 0641005
Molecular Formula : C9H8N4
Molecular Weight : 172.19
stdClass Object
(
[pname] => 4-Methyl-N-(3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide
[catalogue_number] => PA 14 0641006
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 529.53
[form] => C28H22F3N7O
[cas] => 641571-05-3
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4-Methyl-N-(3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide
Catalogue No.:PA 14 0641006
Molecular Formula : C28H22F3N7O
Molecular Weight : 529.53
stdClass Object
(
[pname] => Tert-butyl 4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoate
[catalogue_number] => PA 14 0641007
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[chemical_name] =>
[weight] => 362.43
[form] => C21H22N4O2
[cas] => 2468737-73-5
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Tert-butyl 4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoate
Catalogue No.:PA 14 0641007
Molecular Formula : C21H22N4O2
Molecular Weight : 362.43
stdClass Object
(
[pname] => N-(3-(2,4-Dimethyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide
[catalogue_number] => PA 14 0641008
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 543.55
[form] => C29H24F3N7O
[cas] => 2119583-25-2
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N-(3-(2,4-Dimethyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide
Catalogue No.:PA 14 0641008
Molecular Formula : C29H24F3N7O
Molecular Weight : 543.55
stdClass Object
(
[pname] => 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzonitrile
[catalogue_number] => PA 14 0641009
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[chemical_name] =>
[weight] => 251.21
[form] => C12H8F3N3
[cas] => 641571-12-2
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3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzonitrile
Catalogue No.:PA 14 0641009
Molecular Formula : C12H8F3N3
Molecular Weight : 251.21
stdClass Object
(
[pname] => 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzamide
[catalogue_number] => PA 14 0641010
[category_ids] => ,70,75,76,78,82,
[chemical_name] =>
[weight] => 269.23
[form] => C12H10F3N3O
[cas] => 917391-28-7
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3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzamide
Catalogue No.:PA 14 0641010
Molecular Formula : C12H10F3N3O
Molecular Weight : 269.23
stdClass Object
(
[pname] => 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid
[catalogue_number] => PA 14 0641011
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[chemical_name] =>
[weight] => 270.21
[form] => C12H9F3N2O2
[cas] => 641571-13-3
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3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid
Catalogue No.:PA 14 0641011
Molecular Formula : C12H9F3N2O2
Molecular Weight : 270.21
stdClass Object
(
[pname] => (E)-3-(Dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
[catalogue_number] => PA 14 0641012
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 176.22
[form] => C10H12N2O
[cas] => 123367-26-0
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(E)-3-(Dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
Catalogue No.:PA 14 0641012
Molecular Formula : C10H12N2O
Molecular Weight : 176.22
stdClass Object
(
[pname] => 3-Bromo-5-nitrobenzotrifluoride
[catalogue_number] => PA 14 0641013
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[chemical_name] =>
[weight] => 270.01
[form] => C7H3BrF3NO2
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3-Bromo-5-nitrobenzotrifluoride
Catalogue No.:PA 14 0641013
Molecular Formula : C7H3BrF3NO2
Molecular Weight : 270.01
stdClass Object
(
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[catalogue_number] => PA 14 0641014
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[chemical_name] =>
[weight] => 404.35
[form] => C19H15F3N4O3
[cas] => 1157857-29-8
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4-Methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-nitrobenzamide
Catalogue No.:PA 14 0641014
Molecular Formula : C19H15F3N4O3
Molecular Weight : 404.35
stdClass Object
(
[pname] => 2,3-Dihydroxy-4-((2-methyl-5-((3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)carbamoyl)phenyl)(4-(pyridin-3-yl)pyrimidin-2-yl)amino)-4-oxobutanoic acid
[catalogue_number] => PA 14 0641015
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[chemical_name] =>
[weight] => 661.6
[form] => C32H26F3N7O6
[cas] => NA
[pslug] => 2-3-dihydroxy-4-2-methyl-5-3-4-methyl-1h-imidazol-1-yl-5-trifluoromethyl-phenyl-carbamoyl-phenyl-4-pyridin-3-yl-pyrimidin-2-yl-amino-4-oxobutanoic-acid-pa140641015
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2,3-Dihydroxy-4-((2-methyl-5-((3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)carbamoyl)phenyl)(4-(pyridin-3-yl)pyrimidin-2-yl)amino)-4-oxobutanoic acid
stdClass Object
(
[pname] => 3-Guanidino-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide
[catalogue_number] => PA 14 0641016
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 416.41
[form] => C20H19F3N6O
[cas] => 1345336-53-9
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3-Guanidino-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide
Catalogue No.:PA 14 0641016
Molecular Formula : C20H19F3N6O
Molecular Weight : 416.41
stdClass Object
(
[pname] => tert-Butyl (3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)carbamate
[catalogue_number] => PA 14 0641018
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[weight] => 341.33
[form] => C16H18F3N3O2
[cas] => 641571-14-4
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tert-Butyl (3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)carbamate
Catalogue No.:PA 14 0641018
Molecular Formula : C16H18F3N3O2
Molecular Weight : 341.33
stdClass Object
(
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[catalogue_number] => PA 14 0641017
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[chemical_name] =>
[weight] => 236.11
[form] => C7H3F3N2O4
[cas] => 401-99-0
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3,5-Dinitrobenzotrifluoride
Catalogue No.:PA 14 0641017
Molecular Formula : C7H3F3N2O4
Molecular Weight : 236.11
stdClass Object
(
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[catalogue_number] => PA 14 0641019
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[chemical_name] =>
[weight] => 328.31
[form] => C17H13N4NaO2
[cas] => 1207060-52-3
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Sodium 4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoate
Catalogue No.:PA 14 0641019
Molecular Formula : C17H13N4NaO2
Molecular Weight : 328.31
stdClass Object
(
[pname] => 4-Methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(nitroso(4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide
[catalogue_number] => PA 14 0641020
[category_ids] => ,162,82,78,76,75,70,
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[weight] => 558.53
[form] => C28H21F3N8O2
[cas] => 2925306-68-7
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4-Methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(nitroso(4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide
Catalogue No.:PA 14 0641020
Molecular Formula : C28H21F3N8O2
Molecular Weight : 558.53
stdClass Object
(
[pname] => 4-Methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3,5-bis((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide Hydrochloride
[catalogue_number] => PA 14 0641021
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 736.16
[form] => C37H29ClF3N11O
[cas] => NA
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4-Methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3,5-bis((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide Hydrochloride
Catalogue No.:PA 14 0641021
Molecular Formula : C37H29ClF3N11O
Molecular Weight : 736.16
stdClass Object
(
[pname] => 3-Amino-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide Hydrochloride
[catalogue_number] => PA 14 0641022
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 410.83
[form] => C19H18ClF3N4O
[cas] => 2322358-68-7
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3-Amino-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide Hydrochloride
Catalogue No.:PA 14 0641022
Molecular Formula : C19H18ClF3N4O
Molecular Weight : 410.83
stdClass Object
(
[pname] => 3-(2-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
[catalogue_number] => PA 14 0641023
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 241.22
[form] => C11H10F3N3
[cas] => 641571-06-4
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3-(2-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
Catalogue No.:PA 14 0641023
Molecular Formula : C11H10F3N3
Molecular Weight : 241.22
stdClass Object
(
[pname] => Nilotinib Imidazolyl N-oxide
[catalogue_number] => PA 14 0641025
[category_ids] => ,75,78,70,82,
[chemical_name] =>
[weight] => 545.53
[form] => C28H22F3N7O2
[cas] => 2139382-75-3
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Nilotinib Imidazolyl N-oxide
Catalogue No.:PA 14 0641025
Molecular Formula : C28H22F3N7O2
Molecular Weight : 545.53
stdClass Object
(
[pname] => 3-(2-((2-Methyl-5-((3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)carbamoyl)phenyl)(nitroso)amino)pyrimidin-4-yl)pyridine 1-oxide
[catalogue_number] => PA 14 0641030
[category_ids] => ,75,76,78,82,162,
[chemical_name] =>
[weight] => 574.52
[form] => C28H21F3N8O3
[cas] => NA
[pslug] => 3-2-2-methyl-5-3-4-methyl-1h-imidazol-1-yl-5-trifluoromethyl-phenyl-carbamoyl-phenyl-nitroso-amino-pyrimidin-4-yl-pyridine-1-oxide-pa140641030
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3-(2-((2-Methyl-5-((3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)carbamoyl)phenyl)(nitroso)amino)pyrimidin-4-yl)pyridine 1-oxide
Catalogue No.:PA 14 0641030
Molecular Formula : C28H21F3N8O3
Molecular Weight : 574.52
stdClass Object
(
[pname] => Ethyl 4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoate
[catalogue_number] => PA 14 0641033
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[chemical_name] =>
[weight] => 334.38
[form] => C19H18N4O2
[cas] => 641569-97-3
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Ethyl 4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoate
Catalogue No.:PA 14 0641033
Molecular Formula : C19H18N4O2
Molecular Weight : 334.38
stdClass Object
(
[pname] => Nilotinib N-Oxide (Pyrimidine N3-Oxide)
[catalogue_number] => PA 14 0641034
[category_ids] => ,75,76,78,82,71,70,
[chemical_name] =>
[weight] => 545.53
[form] => C28H22F3N7O2
[cas] => NA
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Nilotinib N-Oxide (Pyrimidine N3-Oxide)
Catalogue No.:PA 14 0641034
Molecular Formula : C28H22F3N7O2
Molecular Weight : 545.53
stdClass Object
(
[pname] => Nilotinib N-Oxide (Pyrimidine N1-Oxide)
[catalogue_number] => PA 14 0641035
[category_ids] => ,75,76,78,82,71,70,
[chemical_name] =>
[weight] => 545.53
[form] => C28H22F3N7O2
[cas] => NA
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Nilotinib N-Oxide (Pyrimidine N1-Oxide)
Catalogue No.:PA 14 0641035
Molecular Formula : C28H22F3N7O2
Molecular Weight : 545.53
stdClass Object
(
[pname] => 5-Amino-2-methylbenzoic Acid
[catalogue_number] => PA 14 0641036
[category_ids] => ,75,76,78,82,71,70,
[chemical_name] =>
[weight] => 151.17
[form] => C8H9NO2
[cas] => 2840-04-2
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5-Amino-2-methylbenzoic Acid
Catalogue No.:PA 14 0641036
Molecular Formula : C8H9NO2
Molecular Weight : 151.17
stdClass Object
(
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[catalogue_number] => PA 14 0641037
[category_ids] => ,75,76,78,82,71,70,
[chemical_name] =>
[weight] => 151.17
[form] => C8H9NO2
[cas] => 52130-17-3
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3-Amino-2-methylbenzoic Acid
Catalogue No.:PA 14 0641037
Molecular Formula : C8H9NO2
Molecular Weight : 151.17
stdClass Object
(
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[catalogue_number] => PA 14 0641038
[category_ids] => ,75,76,78,82,71,70,
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[weight] => 151.17
[form] => C8H9NO2
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3-Amino-5-methylbenzoic Acid
Catalogue No.:PA 14 0641038
Molecular Formula : C8H9NO2
Molecular Weight : 151.17
stdClass Object
(
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[catalogue_number] => PA 14 0641039
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[chemical_name] =>
[weight] => 255.24
[form] => C12H12F3N3
[cas] => 1260802-16-1
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3-(2-Ethyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
Catalogue No.:PA 14 0641039
Molecular Formula : C12H12F3N3
Molecular Weight : 255.24
stdClass Object
(
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[catalogue_number] => PA 14 0641040
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[weight] => 263.3
[form] => C12H17N5O2
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Ethyl 3-(3-(diaminomethylene)guanidino)-4-methylbenzoate