leflunomide
Impurities
- An immunomodulatory drug, Leflunomide is used to treat rheumatoid arthritis and psoriatic arthritis. An inhibitor of enzyme dihydroorotate dehydrogenase which plays a key role in the synthesis of uridine monophosphate (rUMP), which is required for the synthesis of DNA and RNA. Reference standards of Leflunomide API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
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[pname] => Leflunomide - Impurity B
[catalogue_number] => PA 12 08020
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[chemical_name] =>
[weight] => 270.21
[form] => C12H9F3N2O2
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Catalogue No.:PA 12 08020
Molecular Formula : C12H9F3N2O2
Molecular Weight : 270.21
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[pname] => Leflunomide - Impurity E
[catalogue_number] => PA 12 08050
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[weight] => 270.21
[form] => C12H9F3N2O2
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Catalogue No.:PA 12 08050
Molecular Formula : C12H9F3N2O2
Molecular Weight : 270.21
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[pname] => Leflunomide - Impurity F
[catalogue_number] => PA 12 08060
[category_ids] => ,70,71,75,78,80,82,
[chemical_name] =>
[weight] => 270.21
[form] => C12H9F3N2O2
[cas] => 1403564-06-6
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Catalogue No.:PA 12 08060
Molecular Formula : C12H9F3N2O2
Molecular Weight : 270.21
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[pname] => Leflunomide - Impurity G
[catalogue_number] => PA 12 08070
[category_ids] => ,80,71,75,78,70,82,
[chemical_name] =>
[weight] => 216.24
[form] => C12 H12 N2 O2
[cas] => 724429-16-7
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Catalogue No.:PA 12 08070
Molecular Formula : C12 H12 N2 O2
Molecular Weight : 216.24
stdClass Object
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[pname] => 3-Methylisoxazole-4-carboxylic Acid
[catalogue_number] => PA 12 08510
[category_ids] => ,71,75,78,70,82,
[chemical_name] =>
[weight] => 127.1
[form] => C5H5NO3
[cas] => 17153-20-7
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3-Methylisoxazole-4-carboxylic Acid
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[pname] => 5-Methylisoxazole-3-carboxylic-d4 Acid
[catalogue_number] => PA STI 062330
[category_ids] => ,71,75,98,78,70,82,
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[weight] => 131.12
[form] => C5HD4NO3
[cas] => 1267623-84-6
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5-Methylisoxazole-3-carboxylic-d4 Acid
Catalogue No.:PA STI 062330
Molecular Formula : C5HD4NO3
Molecular Weight : 131.12
stdClass Object
(
[pname] => A77 1726-d4
[catalogue_number] => PA STI 008740
[category_ids] => ,76,75,117,98,
[chemical_name] =>
[weight] => 274.23
[form] => C12H5D4F3N2O2
[cas] => 1185240-22-5
[pslug] => 1185240-22-5-a77-1726-d4-pasti008740
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Catalogue No.:PA STI 008740
Molecular Formula : C12H5D4F3N2O2
Molecular Weight : 274.23
stdClass Object
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[pname] => 5-Hydroxy Leflunomide-d4 (Metabolite M2)
[catalogue_number] => PA STI 049540
[category_ids] => ,80,71,98,76,75,78,70,82,
[chemical_name] =>
[weight] => 290.23
[form] => C12H5D4F3N2O3
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5-Hydroxy Leflunomide-d4 (Metabolite M2)
Catalogue No.:PA STI 049540
Molecular Formula : C12H5D4F3N2O3
Molecular Weight : 290.23
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[pname] => 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide
[catalogue_number] => PA 12 08530
[category_ids] => ,117,76,82,78,75,70,
[chemical_name] =>
[weight] => 270.21
[form] => C12H9F3N2O2
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2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide
Catalogue No.:PA 12 08530
Molecular Formula : C12H9F3N2O2
Molecular Weight : 270.21
stdClass Object
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[pname] => 5-Hydroxy leflunomide
[catalogue_number] => PA 12 0081000
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 286.21
[form] => C12H9F3N2O3
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Catalogue No.:PA 12 0081000
Molecular Formula : C12H9F3N2O3
Molecular Weight : 286.21
stdClass Object
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[pname] => Leflunomide - Impurity A (Hydrochloride)
[catalogue_number] => PA 12 0080011
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[chemical_name] =>
[weight] => 197.59
[form] => C7H7ClF3N
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Leflunomide - Impurity A (Hydrochloride)
Catalogue No.:PA 12 0080011
Molecular Formula : C7H7ClF3N
Molecular Weight : 197.59
stdClass Object
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[pname] => 2-Cyano-N-[2-(trifluoromethyl)phenyl]acetamide
[catalogue_number] => PA 12 0081001
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 228.17
[form] => C10H7F3N2O
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2-Cyano-N-[2-(trifluoromethyl)phenyl]acetamide
Catalogue No.:PA 12 0081001
Molecular Formula : C10H7F3N2O
Molecular Weight : 228.17
