nintedanib
A Nintedanib is used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer. It is a small molecule kinase inhibitor. Reference standards of Nintedanib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
stdClass Object
(
[pname] => Nintedanib
[catalogue_number] => PA 14 54000
[category_ids] => ,79,71,78,70,82,
[chemical_name] =>
[weight] => 539.62
[form] => C31H33N5O4
[cas] => 656247-17-5
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Catalogue No.:PA 14 54000
Molecular Formula : C31H33N5O4
Molecular Weight : 539.62
stdClass Object
(
[pname] => Intedanib E-isomer
[catalogue_number] => PA 14 54510
[category_ids] => ,79,71,78,70,82,
[chemical_name] =>
[weight] => 539.62
[form] => C31H33N5O4
[cas] => NA
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Catalogue No.:PA 14 54510
Molecular Formula : C31H33N5O4
Molecular Weight : 539.62
stdClass Object
(
[pname] => (Z)-1-(2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1,4-dioxide
[catalogue_number] => PA 14 54530
[category_ids] => ,79,71,78,70,82,
[chemical_name] =>
[weight] => 571.62
[form] => C31H33N5O6
[cas] => 3029899-97-3
[pslug] => 3029899-97-3-z-1-2-4-6-methoxycarbonyl-2-oxoindolin-3-ylidene-phenyl-methyl-amino-phenyl-methyl-amino-2-oxoethyl-4-methylpiperazine-1-4-dioxide-pa1454530
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(Z)-1-(2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1,4-dioxide
Catalogue No.:PA 14 54530
Molecular Formula : C31H33N5O6
Molecular Weight : 571.62
stdClass Object
(
[pname] => (Z)-Methyl 3-((methyl(4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
[catalogue_number] => PA 14 54540
[category_ids] => ,79,71,78,70,82,
[chemical_name] =>
[weight] => 553.65
[form] => C32H35N5O4
[cas] => NA
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(Z)-Methyl 3-((methyl(4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 54540
Molecular Formula : C32H35N5O4
Molecular Weight : 553.65
stdClass Object
(
[pname] => (Z)-Methyl 1-acetyl-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
[catalogue_number] => PA 14 54560
[category_ids] => 82,79,78,71,70
[chemical_name] =>
[weight] => 581.66
[form] => C33H35N5O5
[cas] => 2380229-45-6
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(Z)-Methyl 1-acetyl-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 54560
Molecular Formula : C33H35N5O5
Molecular Weight : 581.66
stdClass Object
(
[pname] => (Z)-Methyl 3-(((4-(N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
[catalogue_number] => PA 14 54570
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[chemical_name] =>
[weight] => 441.48
[form] => C26H23N3O4
[cas] => 1139458-48-2
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(Z)-Methyl 3-(((4-(N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 54570
Molecular Formula : C26H23N3O4
Molecular Weight : 441.48
stdClass Object
(
[pname] => Methyl (3Z)-3-[({4-[2-(4-ethylpiperazin-1-yl)-N-methylacetamido]phenyl}amino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
[catalogue_number] => PA 14 54590
[category_ids] => ,77,71,85,83,78,70,82,
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[weight] => 553.65
[form] => C32H35N5O4
[cas] => NA
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Methyl (3Z)-3-[({4-[2-(4-ethylpiperazin-1-yl)-N-methylacetamido]phenyl}amino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
Catalogue No.:PA 14 54590
Molecular Formula : C32H35N5O4
Molecular Weight : 553.65
stdClass Object
(
[pname] => (Z)-1-(2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1-oxide
[catalogue_number] => PA 14 54600
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[weight] => 555.62
[form] => C31H33N5O5
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(Z)-1-(2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1-oxide
Catalogue No.:PA 14 54600
Molecular Formula : C31H33N5O5
Molecular Weight : 555.62
stdClass Object
(
[pname] => Ethyl (3Z)-3-[({4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl}amino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
[catalogue_number] => PA 14 54610
[category_ids] => 85,83,77,71,70,78,82
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[weight] => 553.65
[form] => C32H35N5O4
[cas] => 1139455-52-9
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Ethyl (3Z)-3-[({4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl}amino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
Catalogue No.:PA 14 54610
Molecular Formula : C32H35N5O4
Molecular Weight : 553.65
stdClass Object
(
[pname] => Nintedanib Esylate
[catalogue_number] => PA 14 54620
[category_ids] => 85,83,77,71,82,78,70
[chemical_name] =>
[weight] => 649.76
[form] => C33H39N5O7S
[cas] => 656247-18-6
[pslug] => 656247-18-6-nintedanib-esylate-pa1454620
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Catalogue No.:PA 14 54620
Molecular Formula : C33H39N5O7S
Molecular Weight : 649.76
stdClass Object
(
[pname] => Intedanib-d3
[catalogue_number] => PA STI 053200
[category_ids] => 98,82,79,78,71,70
[chemical_name] =>
[weight] => 542.64
[form] => C31H30D3N5O4
[cas] => 1624587-84-3
[pslug] => 1624587-84-3-intedanib-d3-pasti053200
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Catalogue No.:PA STI 053200
Molecular Formula : C31H30D3N5O4
Molecular Weight : 542.64
stdClass Object
(
[pname] => Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxo-1-propionylindoline-6-carboxylate
[catalogue_number] => PA 14 0541035
[category_ids] => ,71,78,70,82,
[chemical_name] =>
[weight] => 595.7
[form] => C34H37N5O5
[cas] => 2097505-01-4
[pslug] => 2097505-01-4-methyl-z-3-4-n-methyl-2-4-methylpiperazin-1-yl-acetamido-phenyl-amino-phenyl-methylene-2-oxo-1-propionylindoline-6-carboxylate-pa140541035
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Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxo-1-propionylindoline-6-carboxylate
stdClass Object
(
[pname] => N-nitroso-N-desmethylnintedanib
[catalogue_number] => PA 14 0541039
[category_ids] => ,70,71,78,79,82,162,
[chemical_name] =>
[weight] => 554.61
[form] => C30H30N6O5
[cas] => NA
[pslug] => n-nitroso-n-desmethylnintedanib-pa140541039
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N-nitroso-N-desmethylnintedanib
Catalogue No.:PA 14 0541039
Molecular Formula : C30H30N6O5
Molecular Weight : 554.61
stdClass Object
(
[pname] => Nintedanib Acetamide Impurity
[catalogue_number] => PA 14 0541040
[category_ids] => ,79,71,78,70,82,
[chemical_name] =>
[weight] => 248.33
[form] => C13H20N4O
[cas] => 262368-25-2
[pslug] => 262368-25-2-nintedanib-acetamide-impurity-pa140541040
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Nintedanib Acetamide Impurity
Catalogue No.:PA 14 0541040
Molecular Formula : C13H20N4O
Molecular Weight : 248.33
stdClass Object
(
[pname] => Nintedanib 4-Nitrophenyl 2-(4-Nitroso)
[catalogue_number] => PA 14 0541042
[category_ids] => ,70,71,78,79,82,162,
[chemical_name] =>
[weight] => 307.31
[form] => C13H17N5O4
[cas] => 2490403-92-2
[pslug] => 2490403-92-2-nintedanib-4-nitrophenyl-2-4-nitroso-pa140541042
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Nintedanib 4-Nitrophenyl 2-(4-Nitroso)
Catalogue No.:PA 14 0541042
Molecular Formula : C13H17N5O4
Molecular Weight : 307.31
stdClass Object
(
[pname] => Methyl 1-acetyl-2-oxoindoline-6-carboxylate
[catalogue_number] => PA 14 0541043
[category_ids] => ,79,71,78,70,82,
[chemical_name] =>
[weight] => 233.22
[form] => C12H11NO4
[cas] => 676326-36-6
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Methyl 1-acetyl-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541043
Molecular Formula : C12H11NO4
Molecular Weight : 233.22
stdClass Object
(
[pname] => Dimethyl 3,3'-(((((2,2'-(piperazine-1,4-diyl)bis(acetyl))bis(methylazanediyl))bis(4,1-phenylene))bis(azanediyl))bis(phenylmethanylylidene))bis(1-acetyl-2-oxoindoline-6-carboxylate)
[catalogue_number] => PA 14 0541044
[category_ids] => ,79,71,78,82,
[chemical_name] =>
[weight] => 1049.15
[form] => C60H56N8O10
[cas] => 2410649-55-5
[pslug] => 2410649-55-5-dimethyl-3-3-2-2-piperazine-1-4-diyl-bis-acetyl-bis-methylazanediyl-bis-4-1-phenylene-bis-azanediyl-bis-phenylmethanylylidene-bis-1-acetyl-2-oxoindoline-6-carboxylate-pa140541044
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Dimethyl 3,3'-(((((2,2'-(piperazine-1,4-diyl)bis(acetyl))bis(methylazanediyl))bis(4,1-phenylene))bis(azanediyl))bis(phenylmethanylylidene))bis(1-acetyl-2-oxoindoline-6-carboxylate)
Catalogue No.:PA 14 0541044
Molecular Formula : C60H56N8O10
Molecular Weight : 1049.15
stdClass Object
(
[pname] => 1-(2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1,4-dioxide
[catalogue_number] => PA 14 0541045
[category_ids] => ,79,71,78,70,82,
[chemical_name] =>
[weight] => 571.63
[form] => C31H33N5O6
[cas] => 2734676-68-5
[pslug] => 2734676-68-5-1-2-4-6-methoxycarbonyl-2-oxoindolin-3-ylidene-phenyl-methyl-amino-phenyl-methyl-amino-2-oxoethyl-4-methylpiperazine-1-4-dioxide-pa140541045
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1-(2-((4-(((6-(Methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)-4-methylpiperazine 1,4-dioxide
Catalogue No.:PA 14 0541045
Molecular Formula : C31H33N5O6
Molecular Weight : 571.63
stdClass Object
(
[pname] => N-(4-Aminophenyl)-2-chloro-N-methylacetamide
[catalogue_number] => PA 14 0541046
[category_ids] => ,79,71,78,70,82,
[chemical_name] =>
[weight] => 198.65
[form] => C9H11ClN2O
[cas] => 855860-75-2
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N-(4-Aminophenyl)-2-chloro-N-methylacetamide
Catalogue No.:PA 14 0541046
Molecular Formula : C9H11ClN2O
Molecular Weight : 198.65
stdClass Object
(
[pname] => Methyl 4-chloro-3-nitrobenzoate
[catalogue_number] => PA 14 0541047
[category_ids] => ,82,78,76,79,71,78,70,82,75,70,
[chemical_name] =>
[weight] => 215.59
[form] => C8H6ClNO4
[cas] => 14719-83-6
[pslug] => 14719-83-6-methyl-4-chloro-3-nitrobenzoate-pa140541047
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Methyl 4-chloro-3-nitrobenzoate
Catalogue No.:PA 14 0541047
Molecular Formula : C8H6ClNO4
Molecular Weight : 215.59
stdClass Object
(
[pname] => N-Methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide
[catalogue_number] => PA 14 0541048
[category_ids] => ,82,78,76,79,71,78,70,82,75,70,
[chemical_name] =>
[weight] => 292.34
[form] => C14H20N4O3
[cas] => 1139453-98-7
[pslug] => 1139453-98-7-n-methyl-2-4-methylpiperazin-1-yl-n-4-nitrophenyl-acetamide-pa140541048
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N-Methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide
Catalogue No.:PA 14 0541048
Molecular Formula : C14H20N4O3
Molecular Weight : 292.34
stdClass Object
(
[pname] => Methyl 3-(((4-hydroxyphenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
[catalogue_number] => PA 14 0541049
[category_ids] => ,79,71,78,70,82,
[chemical_name] =>
[weight] => 386.41
[form] => C23H18N2O4
[cas] => 2519501-85-8
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Methyl 3-(((4-hydroxyphenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541049
Molecular Formula : C23H18N2O4
Molecular Weight : 386.41
stdClass Object
(
[pname] => Dimethyl 2-(2-amino-4-(methoxycarbonyl)phenyl)malonate
[catalogue_number] => PA 14 0541050
[category_ids] => ,79,71,78,70,82,
[chemical_name] =>
[weight] => 281.26
[form] => C13H15NO6
[cas] => 2765161-53-1
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Dimethyl 2-(2-amino-4-(methoxycarbonyl)phenyl)malonate
Catalogue No.:PA 14 0541050
Molecular Formula : C13H15NO6
Molecular Weight : 281.26
stdClass Object
(
[pname] => 6-(Methoxycarbonyl)-2-oxoindoline-3-carboxylic Acid
[catalogue_number] => PA 14 0541051
[category_ids] => ,79,71,78,70,82,
[chemical_name] =>
[weight] => 235.2
[form] => C11H9NO5
[cas] => NA
[pslug] => 6-methoxycarbonyl-2-oxoindoline-3-carboxylic-acid-pa140541051
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6-(Methoxycarbonyl)-2-oxoindoline-3-carboxylic Acid
stdClass Object
(
[pname] => 2-(4-(Methoxycarbonyl)-2-nitrophenyl)acetic Acid
[catalogue_number] => PA 14 0541052
[category_ids] => ,79,71,78,70,82,
[chemical_name] =>
[weight] => 239.18
[form] => C10H9NO6
[cas] => 1351810-28-0
[pslug] => 1351810-28-0-2-4-methoxycarbonyl-2-nitrophenyl-acetic-acid-pa140541052
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2-(4-(Methoxycarbonyl)-2-nitrophenyl)acetic Acid
Catalogue No.:PA 14 0541052
Molecular Formula : C10H9NO6
Molecular Weight : 239.18
stdClass Object
(
[pname] => N-(4-Aminophenyl)-2,2-dichloro-N-methylacetamide
[catalogue_number] => PA 14 0541053
[category_ids] => ,79,71,78,70,82,
[chemical_name] =>
[weight] => 233.09
[form] => C9H10Cl2N2O
[cas] => 99846-70-5
[pslug] => 99846-70-5-n-4-aminophenyl-2-2-dichloro-n-methylacetamide-pa140541053
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N-(4-Aminophenyl)-2,2-dichloro-N-methylacetamide
Catalogue No.:PA 14 0541053
Molecular Formula : C9H10Cl2N2O
Molecular Weight : 233.09
stdClass Object
(
[pname] => N-(4-Aminophenyl)-N-methyl-2,2-bis(4-methylpiperazin-1-yl)acetamide
[catalogue_number] => PA 14 0541054
[category_ids] => ,79,71,78,70,82,
[chemical_name] =>
[weight] => 360.51
[form] => C19H32N6O
[cas] => NA
[pslug] => n-4-aminophenyl-n-methyl-2-2-bis-4-methylpiperazin-1-yl-acetamide-pa140541054
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N-(4-Aminophenyl)-N-methyl-2,2-bis(4-methylpiperazin-1-yl)acetamide
Catalogue No.:PA 14 0541054
Molecular Formula : C19H32N6O
Molecular Weight : 360.51
stdClass Object
(
[pname] => N-(4-Aminophenyl)-2-(4-methylpiperazin-1-yl)-N-(2-(piperazin-1-yl)acetyl)acetamide
[catalogue_number] => PA 14 0541055
[category_ids] => ,79,71,78,70,82,
[chemical_name] =>
[weight] => 374.49
[form] => C19H30N6O2
[cas] => NA
[pslug] => n-4-aminophenyl-2-4-methylpiperazin-1-yl-n-2-piperazin-1-yl-acetyl-acetamide-pa140541055
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N-(4-Aminophenyl)-2-(4-methylpiperazin-1-yl)-N-(2-(piperazin-1-yl)acetyl)acetamide
Catalogue No.:PA 14 0541055
Molecular Formula : C19H30N6O2
Molecular Weight : 374.49
stdClass Object
(
[pname] => N-(4-Aminophenyl)-2-((4-aminophenyl)(methyl)amino)acetamide
[catalogue_number] => PA 14 0541056
[category_ids] => ,79,71,78,70,82,
[chemical_name] =>
[weight] => 270.34
[form] => C15H18N4O
[cas] => NA
[pslug] => n-4-aminophenyl-2-4-aminophenyl-methyl-amino-acetamide-pa140541056
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N-(4-Aminophenyl)-2-((4-aminophenyl)(methyl)amino)acetamide
Catalogue No.:PA 14 0541056
Molecular Formula : C15H18N4O
Molecular Weight : 270.34
stdClass Object
(
[pname] => N-(4-Aminophenyl)-N-methyl-2-(piperazin-1-yl)acetamide
[catalogue_number] => PA 14 0541057
[category_ids] => ,79,71,78,70,82,
[chemical_name] =>
[weight] => 248.33
[form] => C13H20N4O
[cas] => 2243384-71-4
[pslug] => 2243384-71-4-n-4-aminophenyl-n-methyl-2-piperazin-1-yl-acetamide-pa140541057
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N-(4-Aminophenyl)-N-methyl-2-(piperazin-1-yl)acetamide
Catalogue No.:PA 14 0541057
Molecular Formula : C13H20N4O
Molecular Weight : 248.33
stdClass Object
(
[pname] => Methyl (Z)-3-(((4-(methylamino)phenyl)(nitroso)amino)(phenyl)methylene)-2-oxoindoline-5-carboxylate
[catalogue_number] => PA 14 0541058
[category_ids] => ,79,71,78,70,82,162,
[chemical_name] =>
[weight] => 428.45
[form] => C24H20N4O4
[cas] => NA
[pslug] => methyl-z-3-4-methylamino-phenyl-nitroso-amino-phenyl-methylene-2-oxoindoline-5-carboxylate-pa140541058
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Methyl (Z)-3-(((4-(methylamino)phenyl)(nitroso)amino)(phenyl)methylene)-2-oxoindoline-5-carboxylate
Catalogue No.:PA 14 0541058
Molecular Formula : C24H20N4O4
Molecular Weight : 428.45
stdClass Object
(
[pname] => N-Nitroso-N-desmethyl nintedanib D8
[catalogue_number] => PA STI 089887
[category_ids] => ,79,71,78,70,82,
[chemical_name] =>
[weight] => 562.66
[form] => C30H22D8N6O5
[cas] => NA
[pslug] => n-nitroso-n-desmethyl-nintedanib-d8-pasti089887
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N-Nitroso-N-desmethyl nintedanib D8
Catalogue No.:PA STI 089887
Molecular Formula : C30H22D8N6O5
Molecular Weight : 562.66
stdClass Object
(
[pname] => Methyl 3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
[catalogue_number] => PA 14 0541059
[category_ids] => ,79,71,78,70,82,
[chemical_name] =>
[weight] => 309.32
[form] => C18H15NO4
[cas] => NA
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Methyl 3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541059
Molecular Formula : C18H15NO4
Molecular Weight : 309.32
stdClass Object
(
[pname] => Methyl (Z)-3-((4-(2-((4-((((Z)-6-(methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)piperazin-1-yl)(phenyl)methylene)-2-oxoindoline-6-carboxylate
[catalogue_number] => PA 14 0541060
[category_ids] => ,79,71,78,70,82,
[chemical_name] =>
[weight] => 802.89
[form] => C47H42N6O7
[cas] => NA
[pslug] => methyl-z-3-4-2-4-z-6-methoxycarbonyl-2-oxoindolin-3-ylidene-phenyl-methyl-amino-phenyl-methyl-amino-2-oxoethyl-piperazin-1-yl-phenyl-methylene-2-oxoindoline-6-carboxylate-pa140541060
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Methyl (Z)-3-((4-(2-((4-((((Z)-6-(methoxycarbonyl)-2-oxoindolin-3-ylidene)(phenyl)methyl)amino)phenyl)(methyl)amino)-2-oxoethyl)piperazin-1-yl)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Catalogue No.:PA 14 0541060
Molecular Formula : C47H42N6O7
Molecular Weight : 802.89