tacrolimus
A macrolide lactone, Tacrolimus is an immunosupressant drug. Tacrolimus is a macrolide calcineurin inhibitor used mainly after allogeneic organ transplant to lower the risk of organ rejection. Topical ointment is used to treat severe cases of atopic dermatitis (eczema)Reference standards of Tacrolimus API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
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[pname] => Tacrolimus
[catalogue_number] => PA 20 67000
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[weight] => 804.02
[form] => C44H69NO12
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Catalogue No.:PA 20 67000
Molecular Formula : C44H69NO12
Molecular Weight : 804.02
stdClass Object
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[pname] => Tacrolimus 31 DMT
[catalogue_number] => PA 20 01580
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Catalogue No.:PA 20 01580
Molecular Formula : C43H67NO12
Molecular Weight : 789.99
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[catalogue_number] => PA 20 01590
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Catalogue No.:PA 20 01590
Molecular Formula : C43H67NO12
Molecular Weight : 789.99
stdClass Object
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[pname] => Tacrolimus Hydroxy Acid Impurity
[catalogue_number] => PA 20 01600
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[weight] => 822.03
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Tacrolimus Hydroxy Acid Impurity
Catalogue No.:PA 20 01600
Molecular Formula : C44H71NO13
Molecular Weight : 822.03
stdClass Object
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Tacrolimus Lactone Isomer
Catalogue No.:PA 20 01620
Molecular Formula : C44H69NO12
Molecular Weight : 804.02
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[form] => C11H18O3
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Tacrolimus Methyl Acryl Aldehyde
Catalogue No.:PA 20 01630
Molecular Formula : C11H18O3
Molecular Weight : 198.26
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[pname] => Tacrolimus 21-Carboxy Acid
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Tacrolimus 21-Carboxy Acid
Catalogue No.:PA 20 01640
Molecular Formula : C44H71NO13
Molecular Weight : 822.06
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15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-oxocyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, [3S-[3R*[E(1S*,4R*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]
Catalogue No.:PA 20 01650
Molecular Formula : C43H65NO12
Molecular Weight : 787.98
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15,19:20,23-Diepoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,21(4H,8H,23H)-trione, 5,6,11,12,13,14,15,16,17,18,19,20,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)
Catalogue No.:PA 20 01660
Molecular Formula : C44H69NO12
Molecular Weight : 804.02
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Catalogue No.:PA 20 01670
Molecular Formula : C44H69NO12
Molecular Weight : 804.02
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Catalogue No.:PA 20 01680
Molecular Formula : C43H69NO11
Molecular Weight : 776.01
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[pname] => 13-O-Desmethylated Tacrolimus
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13-O-Desmethylated Tacrolimus
Catalogue No.:PA 20 01690
Molecular Formula : C44H69NO12
Molecular Weight : 804.02
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24,32-Bis-O-(tert-butyldimethylsilyl)-FK-506-13C, D2 (Major)
Catalogue No.:PA STI 013110
Molecular Formula : C5513CH95D2NO12Si2
Molecular Weight : 1035.54
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FK-506-13C,D2 (Major) (Tacrolimus)
Catalogue No.:PA STI 041210
Molecular Formula : C4313CH67D2NO12
Molecular Weight : 807.02
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(S)-1-(2-((2R,3R,5S,6R)-6-((1S,3S,5E,7R,10S,11R,12S,13E)-7-Allyl-10,12-dihydroxy-14-((1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-1-methoxy-3,5,11,13-tetramethyl-8-oxotetradeca-5,13-dien-1-yl)-2-hydroxy-5-methoxy-3-methyltetrahydro-2H-pyran-2-yl)-2-oxoacetyl)piperidine-2-carboxylic Acid
Catalogue No.:PA 20 01710
Molecular Formula : C44H71NO13
Molecular Weight : 822.05
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(E)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(E)-2-(4-hydroxy-3-methoxycyclohexyl)-1-methylvinyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21-(4H,23H)-tetrone
Catalogue No.:PA 20 01730
Molecular Formula : C43H69NO12
Molecular Weight : 792.02
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24-O-Triisopropylsilyl 9-Norketo FK-506
Catalogue No.:PA 20 01740
Molecular Formula : C52H89NO11Si
Molecular Weight : 932.35
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24,33-bis-O-(tert-Butyldimethylsilyl) Tacrolimus
Catalogue No.:PA 20 01760
Molecular Formula : C56H97NO12Si2
Molecular Weight : 1032.56
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24,33-bis-O-(tert-Butyldimethylsilyl)-37,38-dehydro-37,38-dihydroxy-FK-506 (Mixture of Diastereomers)
Catalogue No.:PA 20 01770
Molecular Formula : C56H99NO14Si2
Molecular Weight : 1066.57
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33-tert-Butyldimethylsilyloxy-FK 506
Catalogue No.:PA 20 01780
Molecular Formula : C50H83NO12Si
Molecular Weight : 918.29
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[form] => C4313CH65D4NO12
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Catalogue No.:PA STI 089131
Molecular Formula : C4313CH65D4NO12
Molecular Weight : 809.05
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Tacrolimus Dehydro Impurity
Catalogue No.:PA 20 0671001
Molecular Formula : C44H67NO11
Molecular Weight : 786.02
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Tacrolimus Diene Impurity Mixture of 8R, 8S Isomer
Catalogue No.:PAI 20 067001
Molecular Formula : C44H67NO11
Molecular Weight : 786.02
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13-O-Desmethyl Tacrolimus
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5,6,11,13,14,15,16,17,18,20,24,25,26,26a-Tetradecahydro-5,15,20-trihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-17,20-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,19,21(4H,8H,12H,23H)-tetrone
Catalogue No.:PA 20 0671003
Molecular Formula : C44H69NO13
Molecular Weight : 820.03
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Catalogue No.:PA 20 0671006
Molecular Formula : C44H69NO13
Molecular Weight : 820.03
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13, 31-O-Didesmethyl Tacrolimus
Catalogue No.:PA 20 0671005
Molecular Formula : C42H65NO12
Molecular Weight : 775.98
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13,15-O-Didesmethyl Tacrolimus
Catalogue No.:PA 20 0671004
Molecular Formula : C42H65NO12
Molecular Weight : 775.98
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Tacrolimus C4-epimer Diene
Catalogue No.:PA 20 0671009
Molecular Formula : C44H67NO11
Molecular Weight : 786.02
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Catalogue No.:PA 20 0671010
Molecular Formula : C43H69NO11
Molecular Weight : 776.02
stdClass Object
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(3S,4R,5S,8R,12S,14S,15R,16S,18R,19R,26aS,E)-5,19-Dihydroxy-3-((E)-1-((1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl)prop-1-en-2-yl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-methylallyl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1]oxa[4]azacyclotricosine-1,7,20,21(4H,23H)-tetraone
Catalogue No.:PA 20 0671011
Molecular Formula : C45H71NO12
Molecular Weight : 818.06
stdClass Object
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(3S,4R,5S,8R,12S,14S,15R,16S,18R,19R,25aS,E)-8-Allyl-5,19-Dihydroxy-3-((E)-1-((1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl)prop-1-en-2-yl)-14,16-dimethoxy-4,10,12,18-tetramethyl-3,4,5,6,8,11,12,13,14,15,16,17,18,19,23,24,25,25a-octadecahydro-15,18-(epoxymethano)pyrido[2,1-c][1]oxa[4]azacyclodocosine-1,7,20,26(22H)-tetraone
Catalogue No.:PA 20 0671012
Molecular Formula : C44H69NO12
Molecular Weight : 804.03
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Tacrolimus O-ethyl open ring (peak 1)
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Tacrolimus O-ethyl open ring (peak 2)
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15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-propyl
Catalogue No.:PA 20 0671016
Molecular Formula : C44H71NO12
Molecular Weight : 806.05
stdClass Object
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(3S,4R,5S,8R,12S,14S,15R,16S,18R,19R,26aS,Z)-8-Allyl-5,19-dihydroxy-3-((E)-1-((1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl)prop-1-en-2-yl)-14,16-dimethoxy-4,10,12,18-tetramethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1]oxa[4]azacyclotricosine-1,7,20,21(4H,23H)-tetraone
Catalogue No.:PA 20 0671017
Molecular Formula : C44H69NO12
Molecular Weight : 804.03
stdClass Object
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(3S,4R,5S,8S,12R,14R,15S,16S,18R,25aR,Z)-8-Allyl-5,19-dihydroxy-3-((E)-1-((1R,4R)-4-hydroxy-3-methoxycyclohexyl)prop-1-en-2-yl)-14,16-dimethoxy-4,10,12,18-tetramethyl-3,4,5,6,8,11,12,13,14,15,16,17,18,19,23,24,25,25a-octadecahydro-15,18-(epoxymethano)pyrido[2,1-c][1]oxa[4]azacyclodocosine-1,7,20,26(22H)-tetraone
Catalogue No.:PA 20 0671018
Molecular Formula : C44H69NO12
Molecular Weight : 804.03
stdClass Object
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(3S,6R,10S,12S,13R,14S,16R,17R,24aS,E)-6-Allyl-17-hydroxy-3-((2S,3S,E)-3-hydroxy-5-((1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-4-methylpent-4-en-2-yl)-12,14-dimethoxy-8,10,16-trimethyl-6,9,10,11,12,13,14,15,16,17,22,23,24,24a-tetradecahydro-3H-13,17-epoxypyrido[2,1-c][1]oxa[4]azacyclohenicosine-1,5,18,19(4H,21H)-tetraone
Catalogue No.:PA 20 0671019
Molecular Formula : C44H69NO12
Molecular Weight : 804.03
stdClass Object
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[pname] => (3S,4E,6S,7S,10R,11E,14S,16S,17R,18S,20R,21R,28aS)-10-Allyl-7,21-dihydroxy-3-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-16,18-dimethoxy-4,6,12,14,20-pentamethyl-7,8,10,13,14,15,16,17,18,19,20,21,26,27,28,28a-hexadecahydro-3H-17,21-epoxypyrido[2,1-c][1]oxa[4]azacyclopentacosine-1,9,22,23(6H,25H)-tetraone
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[weight] => 804.03
[form] => C44H69NO12
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(3S,4E,6S,7S,10R,11E,14S,16S,17R,18S,20R,21R,28aS)-10-Allyl-7,21-dihydroxy-3-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-16,18-dimethoxy-4,6,12,14,20-pentamethyl-7,8,10,13,14,15,16,17,18,19,20,21,26,27,28,28a-hexadecahydro-3H-17,21-epoxypyrido[2,1-c][1]oxa[4]azacyclopentacosine-1,9,22,23(6H,25H)-tetraone
Catalogue No.:PA 20 0671020
Molecular Formula : C44H69NO12
Molecular Weight : 804.03
stdClass Object
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[pname] => 11,15-Epoxy-4,6-(epoxymethano)-2H,7H-pyrano[3,2-r]pyrido[2,1-c][1,4]oxaazacyclotricosine-16,17,23(19H)-trione, 25-[(1E)-2-[(1R,3R,4R)-3,4-dihydroxycyclohexyl]-1-methylethenyl]-3,4,4a,8,9,10,11,12,13,14,15,20,21,22,22a,25,26,27,28,28a-eicosahydro-15,27,28a-trihydroxy-10,12-dimethoxy-8,14,26-trimethyl-, (8S,10S,11R,12S,14R,15R,22aS,25S,26R,27S)
[catalogue_number] => PA 20 0671021
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[weight] => 822.00
[form] => C43H67NO14
[cas] => 160892-64-8
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11,15-Epoxy-4,6-(epoxymethano)-2H,7H-pyrano[3,2-r]pyrido[2,1-c][1,4]oxaazacyclotricosine-16,17,23(19H)-trione, 25-[(1E)-2-[(1R,3R,4R)-3,4-dihydroxycyclohexyl]-1-methylethenyl]-3,4,4a,8,9,10,11,12,13,14,15,20,21,22,22a,25,26,27,28,28a-eicosahydro-15,27,28a-trihydroxy-10,12-dimethoxy-8,14,26-trimethyl-, (8S,10S,11R,12S,14R,15R,22aS,25S,26R,27S)
Catalogue No.:PA 20 0671021
Molecular Formula : C43H67NO14
Molecular Weight : 822.00
stdClass Object
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[weight] => 850.1
[form] => C46H75NO13
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(3S,4R,5S,8R,12S,14S,15R,16S,18R,19S,26aS,E)-8-Allyl-20-ethoxy-5,19,20-trihydroxy-3-((E)-1-((1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl)prop-1-en-2-yl)-14,16-dimethoxy-4,10,12,18-tetramethyl-3,4,5,6,11,12,13,14,15,16,17,18,19,20,24,25,26,26a-octadecahydro-7H-15,19-epoxypyrido[2,1-c][1]oxa[4]azacyclotricosine-1,7,21(8H,23H)-trione
stdClass Object
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[pname] => (3S,4R,5S,8R,12S,14S,15R,16S,18R,20R,26aS,E)-8-Allyl-20-ethoxy-5,15,20-trihydroxy-3-((E)-1-((1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl)prop-1-en-2-yl)-14,16-dimethoxy-4,10,12,18-tetramethyl-3,4,5,6,11,12,13,14,15,16,17,18,24,25,26,26a-hexadecahydro-7H-pyrido[2,1-c][1]oxa[4]azacyclotricosine-1,7,19,21(8H,20H,23H)-tetraone
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(3S,4R,5S,8R,12S,14S,15R,16S,18R,20R,26aS,E)-8-Allyl-20-ethoxy-5,15,20-trihydroxy-3-((E)-1-((1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl)prop-1-en-2-yl)-14,16-dimethoxy-4,10,12,18-tetramethyl-3,4,5,6,11,12,13,14,15,16,17,18,24,25,26,26a-hexadecahydro-7H-pyrido[2,1-c][1]oxa[4]azacyclotricosine-1,7,19,21(8H,20H,23H)-tetraone
stdClass Object
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[pname] => (3S,4R,5S,8R,12S,14S,15R,16S,18R,19R,26aS,E)-8-Allyl-5,19-Dihydroxy-3-((E)-1-((1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl)prop-1-en-2-yl)-14,16-dimethoxy-4,10,12,18-tetramethyl-3,4,5,6,11,12,13,14,15,16,17,18,19,20,24,25,26,26a-octadecahydro-7H-15,19:20,23-diepoxypyrido[2,1-c][1]oxa[4]azacyclotricosine-1,7,21(8H,23H)-trione
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(3S,4R,5S,8R,12S,14S,15R,16S,18R,19R,26aS,E)-8-Allyl-5,19-Dihydroxy-3-((E)-1-((1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl)prop-1-en-2-yl)-14,16-dimethoxy-4,10,12,18-tetramethyl-3,4,5,6,11,12,13,14,15,16,17,18,19,20,24,25,26,26a-octadecahydro-7H-15,19:20,23-diepoxypyrido[2,1-c][1]oxa[4]azacyclotricosine-1,7,21(8H,23H)-trione
Catalogue No.:PA 20 0671024
Molecular Formula : C44H69NO12
Molecular Weight : 804.03
stdClass Object
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[form] => C44H69NO12
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(3R,4E,6S,7S,10R,11E,14S,16S,17R,18S,20R,21R,28aR)-10-Allyl-7,21-Dihydroxy-3-((1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-16,18-dimethoxy-4,6,12,14,20-pentamethyl-7,8,10,13,14,15,16,17,18,19,20,21,26,27,28,28a-hexadecahydro-3H-17,21-epoxypyrido[2,1-c][1]oxa[4]azacyclopentacosine-1,9,22,23(6H,25H)-tetraone
Catalogue No.:PA 20 0671025
Molecular Formula : C44H69NO12
Molecular Weight : 804.03
stdClass Object
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(3R,4E,6S,7R,10R,11E,14S,16S,17R,18S,20R,21R,28aS)-10-Allyl-7,21-dihydroxy-3-((1S,3S,4S)-4-hydroxy-3-methoxycyclohexyl)-16,18-dimethoxy-4,6,12,14,20-pentamethyl-7,8,10,13,14,15,16,17,18,19,20,21,26,27,28,28a-hexadecahydro-3H-17,21-epoxypyrido[2,1-c][1]oxa[4]azacyclopentacosine-1,9,22,23(6H,25H)-tetraone
Catalogue No.:PA 20 0671026
Molecular Formula : C44H69NO12
Molecular Weight : 804.03
stdClass Object
(
[pname] => Dihydroxy Tacrolimus
[catalogue_number] => PA 20 0671027
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 838.05
[form] => C44H71NO14
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Catalogue No.:PA 20 0671027
Molecular Formula : C44H71NO14
Molecular Weight : 838.05
stdClass Object
(
[pname] => (1E,3S,4R,5R,8R,9E,12S,14S)-8-allyl-5-hydroxy-1-((1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-14-methoxy-14-((2R,3S,5R)-3-methoxy-5-methyl-6-oxotetrahydro-2H-pyran-2-yl)-2,4,10,12-tetramethyl-7-oxotetradeca-1,9-dien-3-yl (S)-1-formylpiperidine-2-carboxylate
[catalogue_number] => PA 20 0671028
[category_ids] => ,69,82,78,70,
[chemical_name] =>
[weight] => 776.02
[form] => C43H69NO11
[cas] => NA
[pslug] => 1e-3s-4r-5r-8r-9e-12s-14s-8-allyl-5-hydroxy-1-1r-3r-4r-4-hydroxy-3-methoxycyclohexyl-14-methoxy-14-2r-3s-5r-3-methoxy-5-methyl-6-oxotetrahydro-2h-pyran-2-yl-2-4-10-12-tetramethyl-7-oxotetradeca-1-9-dien-3-yl-s-1-formylpiperidine-2-carboxylate-pa200671028
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(1E,3S,4R,5R,8R,9E,12S,14S)-8-allyl-5-hydroxy-1-((1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-14-methoxy-14-((2R,3S,5R)-3-methoxy-5-methyl-6-oxotetrahydro-2H-pyran-2-yl)-2,4,10,12-tetramethyl-7-oxotetradeca-1,9-dien-3-yl (S)-1-formylpiperidine-2-carboxylate
Catalogue No.:PA 20 0671028
Molecular Formula : C43H69NO11
Molecular Weight : 776.02
