afatinib
afatinib is a protein kinase inhibitor, it is used for the treatment of patients with distinct types of metastatic (EGFR mutation positive) non-small cell lung carcinoma (NSCLC), developed by Boehringer Ingelheim. It is also known as Gilotrif and Giotrif. Reference standards of Afatinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
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[catalogue_number] => PA 28 02000
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Catalogue No.:PA 28 02000
Molecular Formula : C24H25ClFN5O3
Molecular Weight : 485.94
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[pname] => N-(3,4-dichlorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
[catalogue_number] => PA 28 02510
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[weight] => 353.14
[form] => C14H7Cl2FN4O2
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N-(3,4-dichlorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
Catalogue No.:PA 28 02510
Molecular Formula : C14H7Cl2FN4O2
Molecular Weight : 353.14
stdClass Object
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[catalogue_number] => PA 28 02520
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[weight] => 340.35
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(S)-N4-(4-Fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
Catalogue No.:PA 28 02520
Molecular Formula : C18H17FN4O2
Molecular Weight : 340.35
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[catalogue_number] => PA 28 02530
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(S)-N4-phenyl-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
Catalogue No.:PA 28 02530
Molecular Formula : C18H18N4O2
Molecular Weight : 322.36
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[catalogue_number] => PA 28 02540
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(S)-N4-(3-chlorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
Catalogue No.:PA 28 02540
Molecular Formula : C18H17ClN4O2
Molecular Weight : 356.81
stdClass Object
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[catalogue_number] => PA 28 02630
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[weight] => 485.94
[form] => C24H25ClFN5O3
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(S,Z)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Catalogue No.:PA 28 02630
Molecular Formula : C24H25ClFN5O3
Molecular Weight : 485.94
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[form] => C18H14ClFN4O4
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(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine
Catalogue No.:PA 28 02650
Molecular Formula : C18H14ClFN4O4
Molecular Weight : 404.78
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(S,E)-N-(4-((3,4-Difluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Catalogue No.:PA 28 02660
Molecular Formula : C24H25F2N5O3
Molecular Weight : 469.48
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(S,E)-N-(4-((4-Chloro-3-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide
Catalogue No.:PA 28 02670
Molecular Formula : C22H20ClFN4O3
Molecular Weight : 442.87
stdClass Object
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(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-hydroxybut-2-enamide
Catalogue No.:PA 28 02760
Molecular Formula : C22H20ClFN4O4
Molecular Weight : 458.87
stdClass Object
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[pname] => N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine
[catalogue_number] => PA 28 02780
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[weight] => 348.72
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N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine
Catalogue No.:PA 28 02780
Molecular Formula : C15H10ClFN4O3
Molecular Weight : 348.72
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(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide
Catalogue No.:PA 28 02800
Molecular Formula : C22H20ClFN4O3
Molecular Weight : 442.87
stdClass Object
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[pname] => Afatinib-d4
[catalogue_number] => PA STI 004270
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[chemical_name] =>
[weight] => 489.96
[form] => C24H21D4ClFN5O3
[cas] => NA
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Catalogue No.:PA STI 004270
Molecular Formula : C24H21D4ClFN5O3
Molecular Weight : 489.96
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[pname] => Afatinib-d6 Dimaleate (N,N-dimethyl-d6)
[catalogue_number] => PA STI 088303
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[weight] => 724.13
[form] => C32H27D6ClFN5O11
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Afatinib-d6 Dimaleate (N,N-dimethyl-d6)
Catalogue No.:PA STI 088303
Molecular Formula : C32H27D6ClFN5O11
Molecular Weight : 724.13
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[weight] => 358.40
[form] => C18H22N4O4
[cas] => 1456696-14-2
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(2E)-N-[3,4-Dihydro-4-oxo-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide
Catalogue No.:PA 28 0021000
Molecular Formula : C18H22N4O4
Molecular Weight : 358.40
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[catalogue_number] => PA 28 0021001
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4-N-(3-Chloro-4-fluorophenyl)-7-[(3R)-oxolan-3-yl]oxyquinazoline-4,6-diamine
stdClass Object
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[pname] => Afatinib Maleic acid Adduct
[catalogue_number] => PA 28 0021002
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[chemical_name] =>
[weight] => 602.02
[form] => C28H29ClFN5O7
[cas] => NA
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Afatinib Maleic acid Adduct
Catalogue No.:PA 28 0021002
Molecular Formula : C28H29ClFN5O7
Molecular Weight : 602.02
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[catalogue_number] => PA 28 0021004
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4-Dimethylaminobut-2-ynoic Acid Hydrochloride
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[catalogue_number] => PA 28 0021005
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[weight] => 404.78
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(R)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine
Catalogue No.:PA 28 0021005
Molecular Formula : C18H14ClFN4O4
Molecular Weight : 404.78
stdClass Object
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[weight] => 502.4
[form] => C24H25Cl2N5O3
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(S,Z)-N-(4-((3,4-Dichlorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
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(S)-N4-(3,4-Difluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
Catalogue No.:PA 28 0021007
Molecular Formula : C18H16F2N4O2
Molecular Weight : 358.35
stdClass Object
(
[pname] => (S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((R)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-3-hydroxybutanamide
[catalogue_number] => PA 28 0021008
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[chemical_name] =>
[weight] => 503.96
[form] => C24H27ClFN5O4
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(S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((R)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-3-hydroxybutanamide
Catalogue No.:PA 28 0021008
Molecular Formula : C24H27ClFN5O4
Molecular Weight : 503.96
stdClass Object
(
[pname] => (R)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((R)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-3-hydroxybutanamide
[catalogue_number] => PA 28 0021009
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[weight] => 503.96
[form] => C24H27ClFN5O4
[cas] => 2413212-23-2
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(R)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((R)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-3-hydroxybutanamide
Catalogue No.:PA 28 0021009
Molecular Formula : C24H27ClFN5O4
Molecular Weight : 503.96
stdClass Object
(
[pname] => Diethyl (S)-(2-((4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)-2-oxoethyl)phosphonate
[catalogue_number] => PA 28 0021011
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 552.92
[form] => C24H27ClFN4O6P
[cas] => 618061-76-0
[pslug] => 618061-76-0-diethyl-s-2-4-3-chloro-4-fluorophenyl-amino-7-tetrahydrofuran-3-yl-oxy-quinazolin-6-yl-amino-2-oxoethyl-phosphonate-pa280021011
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Diethyl (S)-(2-((4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)-2-oxoethyl)phosphonate
Catalogue No.:PA 28 0021011
Molecular Formula : C24H27ClFN4O6P
Molecular Weight : 552.92
stdClass Object
(
[pname] => 4-((4-Chloro-3-fluorophenyl)amino)-6-nitroquinazolin-7-ol
[catalogue_number] => PA 28 0021012
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 334.69
[form] => C14H8ClFN4O3
[cas] => 2475094-95-0
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4-((4-Chloro-3-fluorophenyl)amino)-6-nitroquinazolin-7-ol
Catalogue No.:PA 28 0021012
Molecular Formula : C14H8ClFN4O3
Molecular Weight : 334.69
stdClass Object
(
[pname] => N-(4-Chloro-3-fluorophenyl)-7-fluoro-8-nitroquinazolin-4-amine
[catalogue_number] => PA 28 0021013
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 336.68
[form] => C14H7ClF2N4O2
[cas] => 2475094-96-1
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N-(4-Chloro-3-fluorophenyl)-7-fluoro-8-nitroquinazolin-4-amine
Catalogue No.:PA 28 0021013
Molecular Formula : C14H7ClF2N4O2
Molecular Weight : 336.68
stdClass Object
(
[pname] => (S,E)-N-(4-((3-Chloro-4-fluorophenyl)(nitroso)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
[catalogue_number] => PA 28 0021014
[category_ids] => ,70,75,76,78,82,162,
[chemical_name] =>
[weight] => 514.94
[form] => C24H24ClFN6O4
[cas] => NA
[pslug] => s-e-n-4-3-chloro-4-fluorophenyl-nitroso-amino-7-tetrahydrofuran-3-yl-oxy-quinazolin-6-yl-4-dimethylamino-but-2-enamide-pa280021014
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(S,E)-N-(4-((3-Chloro-4-fluorophenyl)(nitroso)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Catalogue No.:PA 28 0021014
Molecular Formula : C24H24ClFN6O4
Molecular Weight : 514.94
stdClass Object
(
[pname] => (S,Z)-N-(4-((4-Chloro-3-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
[catalogue_number] => PA 28 0021015
[category_ids] => ,75,76,78,70,82,
[chemical_name] =>
[weight] => 485.94
[form] => C24H25ClFN5O3
[cas] => NA
[pslug] => s-z-n-4-4-chloro-3-fluorophenyl-amino-7-tetrahydrofuran-3-yl-oxy-quinazolin-6-yl-4-dimethylamino-but-2-enamide-pa280021015
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(S,Z)-N-(4-((4-Chloro-3-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Catalogue No.:PA 28 0021015
Molecular Formula : C24H25ClFN5O3
Molecular Weight : 485.94
stdClass Object
(
[pname] => N-(3,4-Difluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
[catalogue_number] => PA 28 0021016
[category_ids] => ,69,71,78,70,82,
[chemical_name] =>
[weight] => 320.23
[form] => C14H7F3N4O2
[cas] => 2226537-61-5
[pslug] => 2226537-61-5-n-3-4-difluorophenyl-7-fluoro-6-nitroquinazolin-4-amine-pa280021016
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N-(3,4-Difluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
Catalogue No.:PA 28 0021016
Molecular Formula : C14H7F3N4O2
Molecular Weight : 320.23
stdClass Object
(
[pname] => 4-((3-Chloro-4-fluorophenyl)amino)-6-nitroquinazolin-7-ol
[catalogue_number] => PA 28 0021017
[category_ids] => ,69,71,78,70,82,
[chemical_name] =>
[weight] => 334.69
[form] => C14H8ClFN4O3
[cas] => 1449430-45-8
[pslug] => 1449430-45-8-4-3-chloro-4-fluorophenyl-amino-6-nitroquinazolin-7-ol-pa280021017
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4-((3-Chloro-4-fluorophenyl)amino)-6-nitroquinazolin-7-ol
Catalogue No.:PA 28 0021017
Molecular Formula : C14H8ClFN4O3
Molecular Weight : 334.69
stdClass Object
(
[pname] => (S)-N4-(3,4-Dichlorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
[catalogue_number] => PA 28 0021018
[category_ids] => ,69,71,78,70,82,
[chemical_name] =>
[weight] => 391.25
[form] => C18H16Cl2N4O2
[cas] => 2044709-79-5
[pslug] => 2044709-79-5-s-n4-3-4-dichlorophenyl-7-tetrahydrofuran-3-yl-oxy-quinazoline-4-6-diamine-pa280021018
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(S)-N4-(3,4-Dichlorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
Catalogue No.:PA 28 0021018
Molecular Formula : C18H16Cl2N4O2
Molecular Weight : 391.25
stdClass Object
(
[pname] => 1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((R)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one
[catalogue_number] => PA 28 0021019
[category_ids] => ,75,78,70,82,
[chemical_name] =>
[weight] => 458.87
[form] => C22H20ClFN4O4
[cas] => 2413212-19-6
[pslug] => 2413212-19-6-1-4-3-chloro-4-fluorophenyl-amino-7-r-tetrahydrofuran-3-yl-oxy-quinazolin-6-yl-5-hydroxypyrrolidin-2-one-pa280021019
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1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((R)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one
Catalogue No.:PA 28 0021019
Molecular Formula : C22H20ClFN4O4
Molecular Weight : 458.87
stdClass Object
(
[pname] => 3-(2-Pyridyl)-5,6-bis(4-sulfophenyl)-1,2,4-trazine Disodium Salt Hydrate
[catalogue_number] => PA 28 0021020
[category_ids] => ,75,76,79,69,71,78,82,
[chemical_name] =>
[weight] => 534.47
[form] => C20H16N4Na2O7S2
[cas] => 1083240-27-0
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3-(2-Pyridyl)-5,6-bis(4-sulfophenyl)-1,2,4-trazine Disodium Salt Hydrate
Catalogue No.:PA 28 0021020
Molecular Formula : C20H16N4Na2O7S2
Molecular Weight : 534.47
stdClass Object
(
[pname] => N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-3,4-bis(dimethylamino)butanamide
[catalogue_number] => PA 28 0021021
[category_ids] => ,78,70,82,
[chemical_name] =>
[weight] => 531.03
[form] => C26H32ClFN6O3
[cas] => 2414260-31-2
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N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-3,4-bis(dimethylamino)butanamide
Catalogue No.:PA 28 0021021
Molecular Formula : C26H32ClFN6O3
Molecular Weight : 531.03
stdClass Object
(
[pname] => (E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-hydroxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide
[catalogue_number] => PA 28 0021022
[category_ids] => ,79,69,71,78,70,82,
[chemical_name] =>
[weight] => 415.85
[form] => C20H19ClFN5O2
[cas] => 2223677-61-8
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(E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-hydroxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Catalogue No.:PA 28 0021022
Molecular Formula : C20H19ClFN5O2
Molecular Weight : 415.85
stdClass Object
(
[pname] => N1,N2-Bis(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)oxalamide
[catalogue_number] => PA 28 0021023
[category_ids] => ,79,69,71,78,70,82,
[chemical_name] =>
[weight] => 803.6
[form] => C38H30Cl2F2N8O6
[cas] => 2223677-65-2
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N1,N2-Bis(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)oxalamide
stdClass Object
(
[pname] => (S)-N1-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-N2,N2-dimethyloxalamide
[catalogue_number] => PA 28 0021024
[category_ids] => ,79,69,71,78,70,82,
[chemical_name] =>
[weight] => 473.89
[form] => C22H21ClFN5O4
[cas] => 2223677-66-3
[pslug] => 2223677-66-3-s-n1-4-3-chloro-4-fluorophenyl-amino-7-tetrahydrofuran-3-yl-oxy-quinazolin-6-yl-n2-n2-dimethyloxalamide-pa280021024
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(S)-N1-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-N2,N2-dimethyloxalamide
Catalogue No.:PA 28 0021024
Molecular Formula : C22H21ClFN5O4
Molecular Weight : 473.89
stdClass Object
(
[pname] => Afatinib N-Oxide
[catalogue_number] => PA 28 0021025
[category_ids] => ,79,69,71,78,70,82,
[chemical_name] =>
[weight] => 501.94
[form] => C24H25ClFN5O4
[cas] => 2413212-11-8
[pslug] => 2413212-11-8-afatinib-n-oxide-pa280021025
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Catalogue No.:PA 28 0021025
Molecular Formula : C24H25ClFN5O4
Molecular Weight : 501.94
stdClass Object
(
[pname] => 3-((3-Chloro-4-fluorophenyl)amino)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl)butanamide
[catalogue_number] => PA 28 0021026
[category_ids] => ,82,78,76,70,
[chemical_name] =>
[weight] => 615.51
[form] => C30H30Cl2F2N6O2
[cas] => NA
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3-((3-Chloro-4-fluorophenyl)amino)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl)butanamide
Catalogue No.:PA 28 0021026
Molecular Formula : C30H30Cl2F2N6O2
Molecular Weight : 615.51
stdClass Object
(
[pname] => N-(4-((3-Chloro-4-Fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)amino)-4-(piperidin-1-yl)butanamide
[catalogue_number] => PA 28 0021027
[category_ids] => ,82,78,76,70,
[chemical_name] =>
[weight] => 788.68
[form] => C39H37Cl2F2N9O3
[cas] => NA
[pslug] => n-4-3-chloro-4-fluorophenyl-amino-7-methoxyquinazolin-6-yl-3-4-3-chloro-4-fluorophenyl-amino-7-methoxyquinazolin-6-yl-amino-4-piperidin-1-yl-butanamide-pa280021027
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N-(4-((3-Chloro-4-Fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)amino)-4-(piperidin-1-yl)butanamide
Catalogue No.:PA 28 0021027
Molecular Formula : C39H37Cl2F2N9O3
Molecular Weight : 788.68
stdClass Object
(
[pname] => (S,E)-2-((3-Chloro-4-fluorophenyl)(6-(4-(dimethylamino)but-2-enamido)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-yl)amino)malonic acid
[catalogue_number] => PA 28 0021028
[category_ids] => ,70,71,78,79,82,
[chemical_name] =>
[weight] => 587.99
[form] => C27H27ClFN5O7
[cas] => 2413212-27-6
[pslug] => 2413212-27-6-s-e-2-3-chloro-4-fluorophenyl-6-4-dimethylamino-but-2-enamido-7-tetrahydrofuran-3-yl-oxy-quinazolin-4-yl-amino-malonic-acid-pa280021028
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(S,E)-2-((3-Chloro-4-fluorophenyl)(6-(4-(dimethylamino)but-2-enamido)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-yl)amino)malonic acid
Catalogue No.:PA 28 0021028
Molecular Formula : C27H27ClFN5O7
Molecular Weight : 587.99
stdClass Object
(
[pname] => (R)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
[catalogue_number] => PA 28 0021029
[category_ids] => ,79,69,71,78,70,82,
[chemical_name] =>
[weight] => 485.94
[form] => C24H25ClFN5O3
[cas] => 439081-17-1
[pslug] => 439081-17-1-r-n-4-3-chloro-4-fluorophenyl-amino-7-tetrahydrofuran-3-yl-oxy-quinazolin-6-yl-4-dimethylamino-but-2-enamide-pa280021029
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(R)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Catalogue No.:PA 28 0021029
Molecular Formula : C24H25ClFN5O3
Molecular Weight : 485.94