sorafenib
A tosylate salt of Sorafenib which is a kinase inhibitor drug. It is used for the treatment of kidney, liver and thyroid cancer. It works by inhibiting the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis. Reference standards of Sorafenib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
stdClass Object
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[pname] => Sorafenib
[catalogue_number] => PA 46 17000
[category_ids] => ,79,81,78,70,82,
[chemical_name] =>
[weight] => 464.82
[form] => C21H16ClF3N4O3
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Catalogue No.:PA 46 17000
Molecular Formula : C21H16ClF3N4O3
Molecular Weight : 464.82
stdClass Object
(
[pname] => 2-(4-(4-(3-(2-Chloro-3-(Trifluoromethyl)phenyl)ureido)Phenoxy)-6-Methylpicolinamido)-4-Methylbenzenesulfonic Acid
[catalogue_number] => PA 46 17510
[category_ids] => 82,81,79,78,70
[chemical_name] =>
[weight] => 635.01
[form] => C28H22ClF3N4O6S
[cas] => NA
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2-(4-(4-(3-(2-Chloro-3-(Trifluoromethyl)phenyl)ureido)Phenoxy)-6-Methylpicolinamido)-4-Methylbenzenesulfonic Acid
Catalogue No.:PA 46 17510
Molecular Formula : C28H22ClF3N4O6S
Molecular Weight : 635.01
stdClass Object
(
[pname] => Sorafenib-d3
[catalogue_number] => PA STI 079660
[category_ids] => ,81,98,78,70,82,
[chemical_name] =>
[weight] => 467.84
[form] => C21H13D3ClF3N4O3
[cas] => 1130115-44-4
[pslug] => 1130115-44-4-sorafenib-d3-pasti079660
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Catalogue No.:PA STI 079660
Molecular Formula : C21H13D3ClF3N4O3
Molecular Weight : 467.84
stdClass Object
(
[pname] => N-Desmethyl Sorafenib
[catalogue_number] => PA 46 17630
[category_ids] => ,79,80,71,81,78,70,82,
[chemical_name] =>
[weight] => 450.8
[form] => C20H14ClF3N4O3
[cas] => 284461-74-1
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stdClass Object
(
[pname] => Methyl 4-(4-aminophenoxy)picolinate
[catalogue_number] => PA 46 0171012
[category_ids] => ,79,81,78,70,82,
[chemical_name] =>
[weight] => 244.25
[form] => C13H12N2O3
[cas] => 757251-59-5
[pslug] => 757251-59-5-methyl-4-4-aminophenoxy-picolinate-pa460171012
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Methyl 4-(4-aminophenoxy)picolinate
Catalogue No.:PA 46 0171012
Molecular Formula : C13H12N2O3
Molecular Weight : 244.25
stdClass Object
(
[pname] => Sorafenib Carboxylic Acid Methyl Ester
[catalogue_number] => PA 46 0171013
[category_ids] => ,79,81,78,70,82,
[chemical_name] =>
[weight] => 465.81
[form] => C21H15ClF3N3O4
[cas] => 573673-43-5
[pslug] => 573673-43-5-sorafenib-carboxylic-acid-methyl-ester-pa460171013
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Sorafenib Carboxylic Acid Methyl Ester
Catalogue No.:PA 46 0171013
Molecular Formula : C21H15ClF3N3O4
Molecular Weight : 465.81
stdClass Object
(
[pname] => 1-(4-Ethoxy-3-(trifluoromethyl)phenyl)-3-(2-(3-(hydroxymethyl)piperidin-1-yl)ethyl)urea
[catalogue_number] => PA 46 0171015
[category_ids] => ,79,81,78,70,82,
[chemical_name] =>
[weight] => 389.42
[form] => C18H26F3N3O3
[cas] => 1567296-47-2
[pslug] => 1567296-47-2-1-4-ethoxy-3-trifluoromethyl-phenyl-3-2-3-hydroxymethyl-piperidin-1-yl-ethyl-urea-pa460171015
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1-(4-Ethoxy-3-(trifluoromethyl)phenyl)-3-(2-(3-(hydroxymethyl)piperidin-1-yl)ethyl)urea
Catalogue No.:PA 46 0171015
Molecular Formula : C18H26F3N3O3
Molecular Weight : 389.42
stdClass Object
(
[pname] => N-Methyl-4-(methylamino)picolinamide
[catalogue_number] => PA 46 0171016
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[chemical_name] =>
[weight] => 165.2
[form] => C8H11N3O
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N-Methyl-4-(methylamino)picolinamide
stdClass Object
(
[pname] => 4,6-Dichloro-N-methylpicolinamide
[catalogue_number] => PA 46 0171017
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[chemical_name] =>
[weight] => 205.04
[form] => C7H6Cl2N2O
[cas] => 1379324-09-0
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4,6-Dichloro-N-methylpicolinamide
Catalogue No.:PA 46 0171017
Molecular Formula : C7H6Cl2N2O
Molecular Weight : 205.04
stdClass Object
(
[pname] => Sorafenib-D4
[catalogue_number] => PA STI 089851
[category_ids] => ,98,79,81,78,70,82,
[chemical_name] =>
[weight] => 468.85
[form] => C21H12D4ClF3N4O3
[cas] => 1207560-07-3
[pslug] => 1207560-07-3-sorafenib-d4-pasti089851
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Catalogue No.:PA STI 089851
Molecular Formula : C21H12D4ClF3N4O3
Molecular Weight : 468.85
