Baricitinib was approved in February of 2017 as a second-line orally administered treatment for moderate to severe active rheumatoid arthritis in adults, either as a monotherapy or when combined with methotrexate.Baricitinib is a selective and reversible Janus kinase 1 (JAK1) and 2 (JAK2) inhibitor. Janus kinases belong to the tyrosine protein kinase family and play an important role in the proinflammatory pathway signalling that is frequently over-activated in autoimmune disorders such as rheumatoid arthritis. Reference standards of Baricitinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
stdClass Object ( [pname] => Baricitinib - API Standards [catalogue_number] => PA 29 41000 [category_ids] => ,71,81,78,70,82,88, [chemical_name] => [weight] => 371.42 [form] => C16H17N7O2S [cas] => 1187594-09-7 [pslug] => 1187594-09-7-baricitinib-api-pa2941000 [latest_product] => 0 [linkproducts] => 0 [offers_id] => 8 [offers_name] => Ready Stock [offers_status] => 1 [offers_start_date] => 2024-12-16 [offers_end_date] => 2024-12-31 [pageview] => 2 [offers_slug] => ready-stock [offers_product_id] => 47833 [offers_product_code] => PA 29 41000 [offers_master_id] => 8 [offer_percentage] => 20 % OFF [offers_product_main_cat] => Pharmaceutical Reference Standards )
Catalogue No.:PA 29 41000
CAS :
Molecular Formula : C16H17N7O2S
Molecular Weight : 371.42
stdClass Object ( [pname] => 2-(1-(Ethylsulfonyl)azetidin-3-ylidene)acetonitrile [catalogue_number] => PA 29 0411013 [category_ids] => ,78,123,81, [chemical_name] => [weight] => 186.23 [form] => C7H10N2O2S [cas] => 1187595-85-2 [pslug] => 1187595-85-2-2-1-ethylsulfonyl-azetidin-3-ylidene-acetonitrile-pa290411013 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 29 0411013
Molecular Formula : C7H10N2O2S
Molecular Weight : 186.23
stdClass Object ( [pname] => 1-(1-Ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole [catalogue_number] => PA 29 0411017 [category_ids] => ,71,81,78,70,82,88, [chemical_name] => [weight] => 266.15 [form] => C13H23BN2O3 [cas] => 1029716-44-6 [pslug] => 1029716-44-6-1-1-ethoxyethyl-4-4-4-5-5-tetramethyl-1-3-2-dioxaborolan-2-yl-1h-pyrazole-pa290411017 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 29 0411017
Molecular Formula : C13H23BN2O3
Molecular Weight : 266.15
stdClass Object ( [pname] => tert-Butyl 3-(cyanomethyl)-3-(4-(7-((pivaloyloxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate [catalogue_number] => PA 29 0411023 [category_ids] => ,71,81,78,70,82, [chemical_name] => [weight] => 493.57 [form] => C25H31N7O4 [cas] => 2102104-37-8 [pslug] => 2102104-37-8-tert-butyl-3-cyanomethyl-3-4-7-pivaloyloxy-methyl-7h-pyrrolo-2-3-d-pyrimidin-4-yl-1h-pyrazol-1-yl-azetidine-1-carboxylate-pa290411023 [latest_product] => 0 [linkproducts] => 0 [offers_id] => [offers_name] => [offers_status] => [offers_start_date] => [offers_end_date] => [pageview] => [offers_slug] => [offers_product_id] => [offers_product_code] => [offers_master_id] => [offer_percentage] => [offers_product_main_cat] => )
Catalogue No.:PA 29 0411023
Molecular Formula : C25H31N7O4
Molecular Weight : 493.57
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