axitinib
Axitinib is an indazole derivative. It is most commonly marketed under the name Inlyta® and is available in oral formulations._x000D_ Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3).7. Reference standards of Axitinib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
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[pname] => Axitinib - API Standards
[catalogue_number] => PA 28 45000
[category_ids] => ,80,81,78,70,82,117,
[chemical_name] =>
[weight] => 386.47
[form] => C22H18N4OS
[cas] => 319460-85-0
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Catalogue No.:PA 28 45000
Molecular Formula : C22H18N4OS
Molecular Weight : 386.47
stdClass Object
(
[pname] => (Z)-Axitinib
[catalogue_number] => PA 28 45510
[category_ids] => ,80,81,78,70,82,117,
[chemical_name] =>
[weight] => 386.47
[form] => C22H18N4OS
[cas] => 885126-40-9
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Catalogue No.:PA 28 45510
Molecular Formula : C22H18N4OS
Molecular Weight : 386.47
stdClass Object
(
[pname] => Axitinib Sulfoxide
[catalogue_number] => PA 28 45540
[category_ids] => ,80,81,78,70,82,117,
[chemical_name] =>
[weight] => 402.47
[form] => C22H18N4O2S
[cas] => 1347304-18-0
[pslug] => 1347304-18-0-axitinib-sulfoxide-pa2845540
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Catalogue No.:PA 28 45540
Molecular Formula : C22H18N4O2S
Molecular Weight : 402.47
stdClass Object
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[pname] => (E)-N-Methyl-2-((1-(2-(pyridin-2-yl)ethyl)-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide
[catalogue_number] => PA 28 45550
[category_ids] => ,80,81,78,70,82,88,
[chemical_name] =>
[weight] => 491.61
[form] => C29H25N5OS
[cas] => 1443118-72-6
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(E)-N-Methyl-2-((1-(2-(pyridin-2-yl)ethyl)-3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide
Catalogue No.:PA 28 45550
Molecular Formula : C29H25N5OS
Molecular Weight : 491.61
stdClass Object
(
[pname] => Axitinib N-Glucuronide
[catalogue_number] => PA 28 45560
[category_ids] => ,70,78,80,81,82,88,95,
[chemical_name] =>
[weight] => 562.59
[form] => C28H26N4O7S
[cas] => NA
[pslug] => axitinib-n-glucuronide-pa2845560
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Catalogue No.:PA 28 45560
Molecular Formula : C28H26N4O7S
Molecular Weight : 562.59
stdClass Object
(
[pname] => Axitinib Sulfone Impurity
[catalogue_number] => PA 28 45570
[category_ids] => ,80,81,78,70,82,88,
[chemical_name] =>
[weight] => 418.47
[form] => C22H18N4O3S
[cas] => 1348536-59-3
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Axitinib Sulfone Impurity
Catalogue No.:PA 28 45570
Molecular Formula : C22H18N4O3S
Molecular Weight : 418.47
stdClass Object
(
[pname] => 2-(1H-Indazol-6-ylsulfanyl)-N-methylbenzamide
[catalogue_number] => PA 28 45580
[category_ids] => ,80,81,78,70,82,88,
[chemical_name] =>
[weight] => 283.34
[form] => C15H13N3OS
[cas] => 944835-85-2
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2-(1H-Indazol-6-ylsulfanyl)-N-methylbenzamide
Catalogue No.:PA 28 45580
Molecular Formula : C15H13N3OS
Molecular Weight : 283.34
stdClass Object
(
[pname] => 2-((3-Iodo-2H-indazol-6-yl)thio)-N-methylbenzamide
[catalogue_number] => PA 28 45590
[category_ids] => ,80,81,78,70,82,88,
[chemical_name] =>
[weight] => 409.24
[form] => C15H12IN3OS
[cas] => 885126-34-1
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2-((3-Iodo-2H-indazol-6-yl)thio)-N-methylbenzamide
Catalogue No.:PA 28 45590
Molecular Formula : C15H12IN3OS
Molecular Weight : 409.24
stdClass Object
(
[pname] => Dehydro Axitinib
[catalogue_number] => PA 28 45600
[category_ids] => ,80,81,78,70,82,88,
[chemical_name] =>
[weight] => 388.49
[form] => C22H20N4OS
[cas] => 2749797-54-2
[pslug] => 2749797-54-2-dehydro-axitinib-pa2845600
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Catalogue No.:PA 28 45600
Molecular Formula : C22H20N4OS
Molecular Weight : 388.49
stdClass Object
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[pname] => (E)-2-((3-(2-(Pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzoic Acid
[catalogue_number] => PA 28 45610
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[chemical_name] =>
[weight] => 373.43
[form] => C21H15N3O2S
[cas] => 319462-34-5
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(E)-2-((3-(2-(Pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzoic Acid
Catalogue No.:PA 28 45610
Molecular Formula : C21H15N3O2S
Molecular Weight : 373.43
stdClass Object
(
[pname] => Axitinib Amide Impurity
[catalogue_number] => PA 28 45620
[category_ids] => ,80,81,78,70,82,88,
[chemical_name] =>
[weight] => 372.44
[form] => C21H16N4OS
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Catalogue No.:PA 28 45620
Molecular Formula : C21H16N4OS
Molecular Weight : 372.44
stdClass Object
(
[pname] => Axitinib N-Acetyl impurity
[catalogue_number] => PA 28 45630
[category_ids] => 88,82,81,80,78,70
[chemical_name] =>
[weight] => 428.51
[form] => C24H20N4O2S
[cas] => 1639137-80-6
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Axitinib N-Acetyl impurity
Catalogue No.:PA 28 45630
Molecular Formula : C24H20N4O2S
Molecular Weight : 428.51
stdClass Object
(
[pname] => 6-Iodo-1H-indazole
[catalogue_number] => PA 28 45650
[category_ids] => ,79,80,71,84,
[chemical_name] =>
[weight] => 244.03
[form] => C7H5IN2
[cas] => 261953-36-0
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Catalogue No.:PA 28 45650
Molecular Formula : C7H5IN2
Molecular Weight : 244.03
stdClass Object
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[pname] => 3,6-Diiodo-1H-indazole
[catalogue_number] => PA 28 45660
[category_ids] => ,79,80,71,84,
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[weight] => 369.93
[form] => C7H4I2N2
[cas] => 319472-78-1
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Catalogue No.:PA 28 45660
Molecular Formula : C7H4I2N2
Molecular Weight : 369.93
stdClass Object
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[catalogue_number] => PA 28 45670
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[chemical_name] =>
[weight] => 341.38
[form] => C17H15N3O3S
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2-((1-Acetyl-1H-indazol-6-yl)sulfinyl)-N-methylbenzamide
Catalogue No.:PA 28 45670
Molecular Formula : C17H15N3O3S
Molecular Weight : 341.38
stdClass Object
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[catalogue_number] => PA 28 45680
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[weight] => 299.35
[form] => C15H13N3O2S
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2-((1H-Indazol-6-yl)sulfinyl)-N-methylbenzamide
Catalogue No.:PA 28 45680
Molecular Formula : C15H13N3O2S
Molecular Weight : 299.35
stdClass Object
(
[pname] => 2,2'-(((2,4-di(Pyridin-2-yl)cyclobutane-1,3-diyl)bis(1H-indazole-3,6-diyl))bis(sulfanediyl))bis(N-methylbenzamide)
[catalogue_number] => PA 28 45690
[category_ids] => 88,80,79,78,71
[chemical_name] =>
[weight] => 772.94
[form] => C44H36N8O2S2
[cas] => 1428728-83-9
[pslug] => 1428728-83-9-2-2-2-4-di-pyridin-2-yl-cyclobutane-1-3-diyl-bis-1h-indazole-3-6-diyl-bis-sulfanediyl-bis-n-methylbenzamide-pa2845690
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2,2'-(((2,4-di(Pyridin-2-yl)cyclobutane-1,3-diyl)bis(1H-indazole-3,6-diyl))bis(sulfanediyl))bis(N-methylbenzamide)
Catalogue No.:PA 28 45690
Molecular Formula : C44H36N8O2S2
Molecular Weight : 772.94
stdClass Object
(
[pname] => 2-((3-Iodo-1H-indazol-6-yl)sulfinyl)-N-methylbenzamide
[catalogue_number] => PA 28 45700
[category_ids] => ,79,80,71,88,78,
[chemical_name] =>
[weight] => 425.24
[form] => C15H12IN3O2S
[cas] => 1443118-71-5
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2-((3-Iodo-1H-indazol-6-yl)sulfinyl)-N-methylbenzamide
Catalogue No.:PA 28 45700
Molecular Formula : C15H12IN3O2S
Molecular Weight : 425.24
stdClass Object
(
[pname] => Axitinib-d3
[catalogue_number] => PA STI 009300
[category_ids] => ,80,81,78,70,82,117,98,
[chemical_name] =>
[weight] => 389.49
[form] => C22H15D3N4OS
[cas] => 1126623-89-9
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Catalogue No.:PA STI 009300
Molecular Formula : C22H15D3N4OS
Molecular Weight : 389.49
stdClass Object
(
[pname] => N-Methyl-2-sulfanylbenzamide
[catalogue_number] => PA 28 45730
[category_ids] => ,80,81,78,70,82,
[chemical_name] =>
[weight] => 167.23
[form] => C8H9NOS
[cas] => 20054-45-9
[pslug] => 20054-45-9-n-methyl-2-sulfanylbenzamide-pa2845730
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N-Methyl-2-sulfanylbenzamide
Catalogue No.:PA 28 45730
Molecular Formula : C8H9NOS
Molecular Weight : 167.23
stdClass Object
(
[pname] => N-Nitroso Axitinib
[catalogue_number] => PA 28 0451019
[category_ids] => ,70,78,80,81,82,162,
[chemical_name] =>
[weight] => 415.47
[form] => C22H17N5O2S
[cas] => NA
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Catalogue No.:PA 28 0451019
Molecular Formula : C22H17N5O2S
Molecular Weight : 415.47
stdClass Object
(
[pname] => 2-[(2-Carbamoylphenyl)disulfanyl]benzamide
[catalogue_number] => PA 28 0451020
[category_ids] => ,80,81,78,70,82,117,
[chemical_name] =>
[weight] => 304.38
[form] => C14H12N2O2S2
[cas] => 2527-57-3
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2-[(2-Carbamoylphenyl)disulfanyl]benzamide
Catalogue No.:PA 28 0451020
Molecular Formula : C14H12N2O2S2
Molecular Weight : 304.38
stdClass Object
(
[pname] => (E)-6-Nitro-3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
[catalogue_number] => PA 28 0451024
[category_ids] => ,80,81,78,70,82,
[chemical_name] =>
[weight] => 350.38
[form] => C19H18N4O3
[cas] => 886230-75-7
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(E)-6-Nitro-3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
Catalogue No.:PA 28 0451024
Molecular Formula : C19H18N4O3
Molecular Weight : 350.38