Pemetrexed belongs to a class of drugs known as folate antimetabolites. It is used in treating cancer. This chemotherapy drug works by inhibiting the enzymes used in purine and pyrimidine synthesis, thereby preventing the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells. Reference standards of Pemetrexed Acid API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
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