Osimertinib-impurities | Pharmaffiliates

osimertinib

Osimertinib is used to treat locally advanced or metastatic non-small-cell lung cancer. It is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor.Reference standards of Osimertinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

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(
    [pname] => Osimertinib
    [catalogue_number] => PA 15 51000
    [category_ids] => ,79,80,78,70,82,
    [chemical_name] => 
    [weight] => 499.61
    [form] => C28H33N7O2
    [cas] => 1421373-65-0
    [pslug] => 1421373-65-0-osimertinib-api-pa1551000
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PA 15 51000

Osimertinib


  • Catalogue No.:PA 15 51000

  • CAS :

    1421373-65-0

  • Molecular Formula : C28H33N7O2

  • Molecular Weight : 499.61

stdClass Object
(
    [pname] => 2-Dimethylaminoethanol
    [catalogue_number] => PA 15 51550
    [category_ids] => ,79,75,92,
    [chemical_name] => 
    [weight] => 89.14
    [form] => C4H11NO
    [cas] => 108-01-0
    [pslug] => 108-01-0-2-dimethylaminoethanol-pa1551550
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PA 15 51550

2-Dimethylaminoethanol


  • Catalogue No.:PA 15 51550

  • CAS :

    108-01-0

  • Molecular Formula : C4H11NO

  • Molecular Weight : 89.14

stdClass Object
(
    [pname] => 2-(tert-Butoxy)-4-fluoro-5-nitroaniline
    [catalogue_number] => PA 15 51560
    [category_ids] => ,79,75,80,89,
    [chemical_name] => 
    [weight] => 228.22
    [form] => C10H13FN2O3
    [cas] => NA
    [pslug] => 2-tert-butoxy-4-fluoro-5-nitroaniline-pa1551560
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PA 15 51560

2-(tert-Butoxy)-4-fluoro-5-nitroaniline


  • Catalogue No.:PA 15 51560

  • CAS :

    NA

  • Molecular Formula : C10H13FN2O3

  • Molecular Weight : 228.22

stdClass Object
(
    [pname] => 4-Fluoro-6-methoxy-2,3-dinitroaniline
    [catalogue_number] => PA 15 51570
    [category_ids] => ,79,75,80,89,
    [chemical_name] => 
    [weight] => 231.14
    [form] => C7H6FN3O5
    [cas] => NA
    [pslug] => 4-fluoro-6-methoxy-2-3-dinitroaniline-pa1551570
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PA 15 51570

4-Fluoro-6-methoxy-2,3-dinitroaniline


  • Catalogue No.:PA 15 51570

  • CAS :

    NA

  • Molecular Formula : C7H6FN3O5

  • Molecular Weight : 231.14

stdClass Object
(
    [pname] => Osimertinib N-Methylacrylamide Impurity
    [catalogue_number] => PA 15 0511027
    [category_ids] => ,79,80,78,70,82,
    [chemical_name] => 
    [weight] => 539.64
    [form] => C30H33N7O3
    [cas] => 2850389-35-2
    [pslug] => 2850389-35-2-osimertinib-n-methylacrylamide-impurity-pa150511027
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PA 15 0511027

Osimertinib N-Methylacrylamide Impurity


  • Catalogue No.:PA 15 0511027

  • CAS :

    2850389-35-2

  • Molecular Formula : C30H33N7O3

  • Molecular Weight : 539.64

stdClass Object
(
    [pname] => 1-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)azetidin-2-one
    [catalogue_number] => PA 15 0511028
    [category_ids] => ,79,80,78,70,82,
    [chemical_name] => 
    [weight] => 499.62
    [form] => C28H33N7O2
    [cas] => NA
    [pslug] => 1-2-2-dimethylamino-ethyl-methyl-amino-4-methoxy-5-4-1-methyl-1h-indol-3-yl-pyrimidin-2-yl-amino-phenyl-azetidin-2-one-pa150511028
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PA 15 0511028

1-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)azetidin-2-one


  • Catalogue No.:PA 15 0511028

  • CAS :

    NA

  • Molecular Formula : C28H33N7O2

  • Molecular Weight : 499.62

stdClass Object
(
    [pname] => N-(4-Fluoro-2-methoxyphenyl)acetamide
    [catalogue_number] => PA 15 0511029
    [category_ids] => ,79,80,78,70,82,
    [chemical_name] => 
    [weight] => 183.18
    [form] => C9H10FNO2
    [cas] => 582-11-6
    [pslug] => 582-11-6-n-4-fluoro-2-methoxyphenyl-acetamide-pa150511029
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PA 15 0511029

N-(4-Fluoro-2-methoxyphenyl)acetamide


  • Catalogue No.:PA 15 0511029

  • CAS :

    582-11-6

  • Molecular Formula : C9H10FNO2

  • Molecular Weight : 183.18

stdClass Object
(
    [pname] => 1-Fluoro-5-methoxy-2,4-dinitrobenzene
    [catalogue_number] => PA 15 0511030
    [category_ids] => ,79,80,78,70,82,
    [chemical_name] => 
    [weight] => 216.12
    [form] => C7H5FN2O5
    [cas] => 394-18-3
    [pslug] => 394-18-3-1-fluoro-5-methoxy-2-4-dinitrobenzene-pa150511030
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PA 15 0511030

1-Fluoro-5-methoxy-2,4-dinitrobenzene


  • Catalogue No.:PA 15 0511030

  • CAS :

    394-18-3

  • Molecular Formula : C7H5FN2O5

  • Molecular Weight : 216.12

stdClass Object
(
    [pname] => N-(4-Fluoro-2-methoxy-5-nitrophenyl)acetamide
    [catalogue_number] => PA 15 0511031
    [category_ids] => ,79,80,78,70,82,
    [chemical_name] => 
    [weight] => 228.18
    [form] => C9H9FN2O4
    [cas] => 1823445-36-8
    [pslug] => 1823445-36-8-n-4-fluoro-2-methoxy-5-nitrophenyl-acetamide-pa150511031
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PA 15 0511031

N-(4-Fluoro-2-methoxy-5-nitrophenyl)acetamide


  • Catalogue No.:PA 15 0511031

  • CAS :

    1823445-36-8

  • Molecular Formula : C9H9FN2O4

  • Molecular Weight : 228.18

stdClass Object
(
    [pname] => 2,2,2-Trifluoro-N-(4-fluoro-2-methoxy-5-nitrophenyl)acetamide
    [catalogue_number] => PA 15 0511037
    [category_ids] => ,79,80,78,70,82,
    [chemical_name] => 
    [weight] => 282.15
    [form] => C9H6F4N2O4
    [cas] => 3025819-85-3
    [pslug] => 3025819-85-3-2-2-2-trifluoro-n-4-fluoro-2-methoxy-5-nitrophenyl-acetamide-pa150511037
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PA 15 0511037

2,2,2-Trifluoro-N-(4-fluoro-2-methoxy-5-nitrophenyl)acetamide


  • Catalogue No.:PA 15 0511037

  • CAS :

    3025819-85-3

  • Molecular Formula : C9H6F4N2O4

  • Molecular Weight : 282.15

stdClass Object
(
    [pname] => O-Desmethyl Osimertinib Impurity
    [catalogue_number] => PA 15 0511038
    [category_ids] => ,79,80,78,70,82,
    [chemical_name] => 
    [weight] => 485.59
    [form] => C27H31N7O2
    [cas] => 2226039-64-9
    [pslug] => 2226039-64-9-o-desmethyl-osimertinib-impurity-pa150511038
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PA 15 0511038

O-Desmethyl Osimertinib Impurity


  • Catalogue No.:PA 15 0511038

  • CAS :

    2226039-64-9

  • Molecular Formula : C27H31N7O2

  • Molecular Weight : 485.59

stdClass Object
(
    [pname] => N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-N-(3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)-3-oxopropyl)acrylamide
    [catalogue_number] => PA 15 0511039
    [category_ids] => ,79,80,78,70,82,
    [chemical_name] => 
    [weight] => 999.24
    [form] => C56H66N14O4
    [cas] => 2919324-18-6
    [pslug] => 2919324-18-6-n-2-2-dimethylamino-ethyl-methyl-amino-4-methoxy-5-4-1-methyl-1h-indol-3-yl-pyrimidin-2-yl-amino-phenyl-n-3-2-2-dimethylamino-ethyl-methyl-amino-4-methoxy-5-4-1-methyl-1h-indol-3-yl-pyrimidin-2-yl-amino-phenyl-amino-3-oxopropyl-acrylamide-pa150511039
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PA 15 0511039

N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-N-(3-((2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)amino)-3-oxopropyl)acrylamide


  • Catalogue No.:PA 15 0511039

  • CAS :

    2919324-18-6

  • Molecular Formula : C56H66N14O4

  • Molecular Weight : 999.24

stdClass Object
(
    [pname] => N-(2,4-Dimethoxyphenyl)acrylamide
    [catalogue_number] => PA 15 0511040
    [category_ids] => ,79,80,78,70,82,
    [chemical_name] => 
    [weight] => 207.23
    [form] => C11H13NO3
    [cas] => 187932-63-4
    [pslug] => 187932-63-4-n-2-4-dimethoxyphenyl-acrylamide-pa150511040
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PA 15 0511040

N-(2,4-Dimethoxyphenyl)acrylamide


  • Catalogue No.:PA 15 0511040

  • CAS :

    187932-63-4

  • Molecular Formula : C11H13NO3

  • Molecular Weight : 207.23

stdClass Object
(
    [pname] => N-(2-Methoxyphenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine
    [catalogue_number] => PA 15 0511041
    [category_ids] => ,79,80,78,70,82,
    [chemical_name] => 
    [weight] => 330.39
    [form] => C20H18N4O
    [cas] => 2734281-31-1
    [pslug] => 2734281-31-1-n-2-methoxyphenyl-4-1-methyl-1h-indol-3-yl-pyrimidin-2-amine-pa150511041
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PA 15 0511041

N-(2-Methoxyphenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine


  • Catalogue No.:PA 15 0511041

  • CAS :

    2734281-31-1

  • Molecular Formula : C20H18N4O

  • Molecular Weight : 330.39