Diphenhydramine Hydrochloride is a first-generation antihistamine used to treat a number of conditions including allergic symptoms and itchiness, the common cold, insomnia, motion sickness, and extrapyramidal symptoms. It can also be used for insomnia, symptoms of the common cold, tremor in parkinsonism, and nausea.. Reference standards of Diphenhydramine Hydrochloride API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below
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