Zanubrutinib and its Impurities

Zanubrutinib, sold under the brand name Brukinsa, is for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Reference standards of Zanubrutinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

Displaying 24 results for Zanubrutinib Impurities
PA 26 0391000

(S)-7-(1-Acryloylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

(S)-7-(1-Acryloylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391000

  • CAS :

    NA

  • Molecular Formula : C27H28N6O4

  • Molecular Weight : 500.56

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PA 26 0390000

Zanubrutinib

Zanubrutinib

  • Catalogue No.:PA 26 0390000

  • CAS :

    1691249-45-2

  • Molecular Formula : C27H29N5O3

  • Molecular Weight : 471.56

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PA 26 0391001

Zanubrutinib R-Isomer

Zanubrutinib R-Isomer

  • Catalogue No.:PA 26 0391001

  • CAS :

    1691249-44-1

  • Molecular Formula : C27H29N5O3

  • Molecular Weight : 471.56

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PA 26 0391002

(S)-7-(1-(3-Chloropropanoyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

(S)-7-(1-(3-Chloropropanoyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391002

  • CAS :

    1633351-79-7

  • Molecular Formula : C27H30ClN5O3

  • Molecular Weight : 508.02

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PA 26 0391003

(S)-7-(1-Acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carbonitrile

(S)-7-(1-Acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carbonitrile

  • Catalogue No.:PA 26 0391003

  • CAS :

    2432022-47-2

  • Molecular Formula : C27H27N5O2

  • Molecular Weight : 453.55

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PA 26 0391004

5-Amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile

5-Amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile

  • Catalogue No.:PA 26 0391004

  • CAS :

    NA

  • Molecular Formula : C16H12N4O

  • Molecular Weight : 276.3

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PA 26 0391005

3-(4-(3-Carbamoyl-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl)propanoic Acid

3-(4-(3-Carbamoyl-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl)propanoic Acid

  • Catalogue No.:PA 26 0391005

  • CAS :

    NA

  • Molecular Formula : C27H31N5O4

  • Molecular Weight : 489.58

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PA 26 0391006

2-(4-Phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine

2-(4-Phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine

  • Catalogue No.:PA 26 0391006

  • CAS :

    NA

  • Molecular Formula : C23H26N4O

  • Molecular Weight : 374.49

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PA 26 0391007

4-Acryloyl-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

4-Acryloyl-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391007

  • CAS :

    NA

  • Molecular Formula : C30H31N5O4

  • Molecular Weight : 525.61

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PA 26 0391008

(S)-4-Nitroso-2-(4-phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

(S)-4-Nitroso-2-(4-phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391008

  • CAS :

    NA

  • Molecular Formula : C24H26N6O3

  • Molecular Weight : 446.51

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PA 26 0391009

(S)-7-(1-Nitrosopiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

(S)-7-(1-Nitrosopiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391009

  • CAS :

    NA

  • Molecular Formula : C24H26N6O3

  • Molecular Weight : 446.51

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PA 26 0391010

7-(1-(3-hydroxypropanoyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

7-(1-(3-Hydroxypropanoyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391010

  • CAS :

    NA

  • Molecular Formula : C27H31N5O4

  • Molecular Weight : 489.58

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PA 26 0391011

7-(1-(3-hydroxypropanoyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

(S)-3-(4-(3-Carbamoyl-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl)propanoic Acid

  • Catalogue No.:PA 26 0391011

  • CAS :

    NA

  • Molecular Formula : C27H31N5O4

  • Molecular Weight : 489.58

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PA 26 0391012

(S)-4-Acryloyl-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

(S)-4-Acryloyl-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391012

  • CAS :

    NA

  • Molecular Formula : C30H31N5O4

  • Molecular Weight : 525.61

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PA 26 0391013

(S)-4-(3-(4-((R)-3-Carbamoyl-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl)propanoyl)-2-(4-phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

(S)-4-(3-(4-((R)-3-Carbamoyl-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl)propanoyl)-2-(4-phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391013

  • CAS :

    NA

  • Molecular Formula : C51H56N10O5

  • Molecular Weight : 889.07

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PA 26 0391014

(R)-7-(1-Acryloylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

(R)-7-(1-Acryloylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391014

  • CAS :

    NA

  • Molecular Formula : C27H28N6O4

  • Molecular Weight : 500.56

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PA 26 0391015

(S)-7-(1-(3-Chloropropanoyl)piperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

(S)-7-(1-(3-Chloropropanoyl)piperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391015

  • CAS :

    NA

  • Molecular Formula : C27H29ClN6O4

  • Molecular Weight : 537.02

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PA 26 0391016

(S)-4-Nitroso-2-(4-phenoxyphenyl)-7-(1-propionylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

(S)-4-Nitroso-2-(4-phenoxyphenyl)-7-(1-propionylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391016

  • CAS :

    NA

  • Molecular Formula : C27H30N6O4

  • Molecular Weight : 502.58

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PA 26 0391017

(S)-7-(1-Benzoylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

(S)-7-(1-Benzoylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391017

  • CAS :

    NA

  • Molecular Formula : C31H30N6O4

  • Molecular Weight : 550.62

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PA 26 0391018

(S)-3-(4-(3-Carbamoyl-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl)propanoic Acid

(S)-3-(4-(3-Carbamoyl-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl)propanoic Acid

  • Catalogue No.:PA 26 0391018

  • CAS :

    NA

  • Molecular Formula : C27H30N6O5

  • Molecular Weight : 518.57

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PA 26 0391019

(S)-7-(1-Acetylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

(S)-7-(1-Acetylpiperidin-4-yl)-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391019

  • CAS :

    NA

  • Molecular Formula : C26H28N6O4

  • Molecular Weight : 488.55

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PA 26 0391020

(R)-4-Nitroso-2-(4-phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

(R)-4-Nitroso-2-(4-phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

  • Catalogue No.:PA 26 0391020

  • CAS :

    NA

  • Molecular Formula : C24H26N6O3

  • Molecular Weight : 446.51

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PA 26 0391021

tert-Butyl 4-(3-carbamoyl-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate

tert-Butyl 4-(3-carbamoyl-4-nitroso-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate

  • Catalogue No.:PA 26 0391021

  • CAS :

    NA

  • Molecular Formula : C29H34N6O5

  • Molecular Weight : 546.63

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PA 26 0391022

2-(4-Phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic Acid

2-(4-Phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic Acid

  • Catalogue No.:PA 26 0391022

  • CAS :

    NA

  • Molecular Formula : C24H26N4O3

  • Molecular Weight : 418.5

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