Trametinib may be used alone or in combination with another medication to treat a type of skin cancer. It is a MEK inhibitor drug with anti-cancer activity.Reference standards of Trametinib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Trametinib
Catalogue No.:PA 47 14000
CAS :
Molecular Formula : C26H23FIN5O4
Molecular Weight : 615.39
N-(3-(5-((4-Bromo-2-fluorophenyl)amino)-3-cyclopropyl-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
Catalogue No.:PA 47 14510
Molecular Formula : C26H23BrFN5O4
Molecular Weight : 568.39
3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione
Catalogue No.:PA 47 14520
Molecular Formula : C14H13FIN3O2
Molecular Weight : 401.17
Trametinib-d4
Catalogue No.:PA STI 084082
Molecular Formula : C26H19D4FIN5O4
Molecular Weight : 619.42
Trametinib Dimethyl Sulfoxide
Catalogue No.:PA 47 0141000
Molecular Formula : C28H29FIN5O5S
Molecular Weight : 693.53
1-(3-Aminophenyl)-3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione
Catalogue No.:PA 47 0141001
Molecular Formula : C24H21FIN5O3
Molecular Weight : 573.37
1-(3-Amino-4-hydroxyphenyl)-3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione
Catalogue No.:PA 47 0141002
Molecular Formula : C24H21FIN5O4
Molecular Weight : 589.37
3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7(1H,3H,8H)-trione
Catalogue No.:PA 47 0141005
Molecular Formula : C18H15FIN3O4
Molecular Weight : 483.24
N-(3-((3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl)amino)phenyl)acetamide
Catalogue No.:PA 47 0141004
Molecular Weight : 615.4
Desiodo Trametinib
Catalogue No.:PA 47 0141003
Molecular Formula : C26H24FN5O4
Molecular Weight : 489.51
N-Cyclopropyl-2-((2-fluoro-4-iodophenyl)amino)-4-hydroxy-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
Catalogue No.:PA 47 0141006
Molecular Formula : C17H17FIN3O3
Molecular Weight : 457.24
N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)imino)-8-hydroxy-6,8-dimethyl-2,4,7-trioxo-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
Catalogue No.:PA 47 0141007
Molecular Formula : C26H23FIN5O5
Molecular Weight : 631.4
N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)imino)-8-hydroperoxy-6,8-dimethyl-2,4,7-trioxo-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
Catalogue No.:PA 47 0141008
Molecular Formula : C26H23FIN5O6
Molecular Weight : 647.4
3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-1-(3-nitrophenyl)pyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione
Catalogue No.:PA 47 0141009
Molecular Formula : C24H19FIN5O5
Molecular Weight : 603.35
N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)(nitroso)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
Catalogue No.:PA 47 0141010
Molecular Formula : C26H22FIN6O5
Molecular Weight : 644.4
N-(1-Cyclopropyl-3-(2-fluoro-4-iodophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-N-methylnitrous amide
Catalogue No.:PA 47 0141011
Molecular Formula : C14H12FIN4O3
Molecular Weight : 430.18
N-(3-((3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl)(nitroso)amino)phenyl)acetamide
Catalogue No.:PA 47 0141012
4-((3-Acetamidophenyl)amino)-N-cyclopropyl-2-((2-fluoro-4-iodophenyl)amino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
Catalogue No.:PA 47 0141013
Molecular Formula : C25H25FIN5O3
Molecular Weight : 589.41
3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-1-(2-methylquinolin-7-yl)pyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione
Catalogue No.:PA 47 0141014
Molecular Formula : C28H23FIN5O3
Molecular Weight : 623.43
3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate
Catalogue No.:PA 47 0141015
Molecular Formula : C25H21FIN3O6S
Molecular Weight : 637.42
3'-Aminoacetanilide
Catalogue No.:PA 47 0141016
Molecular Formula : C8H10N2O
Molecular Weight : 150.18
N,N'-(1,3-Phenylene)diacetamide
Catalogue No.:PA 47 0141017
Molecular Formula : C10H12N2O2
Molecular Weight : 192.22
N'-(1-Cyclopropyl-3-(2-fluoro-4-iodophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-N,N-dimethylformimidamide
Catalogue No.:PA 47 0141018
Molecular Formula : C16H16FIN4O2
Molecular Weight : 442.23
N-(3-(3-Cyclopropyl-5-((2-fluorophenyl)(nitroso)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
Catalogue No.:PA 47 0141019
Molecular Formula : C26H23FN6O5
Molecular Weight : 518.51
N-(1-(3-Aminophenyl)-3-cyclopropyl-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,6,7-hexahydropyrido[4,3-d]pyrimidin-5-yl)-N-(2-fluoro-4-iodophenyl)nitrous amide
Catalogue No.:PA 47 0141020
Molecular Formula : C24H20FIN6O4
Molecular Weight : 602.36
4-((3-Acetamidophenyl)amino)-N-cyclopropyl-2-((2-fluoro-4-iodophenyl)(nitroso)amino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
Catalogue No.:PA 47 0141021
Molecular Formula : C25H24FIN6O4
Molecular Weight : 618.41
4-((3-Acetamidophenyl)(nitroso)amino)-N-cyclopropyl-2-((2-fluoro-4-iodophenyl)(nitroso)amino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
Catalogue No.:PA 47 0141022
Molecular Formula : C25H23FIN7O5
Molecular Weight : 647.41
Desacetyl Trametinib N-Glucoronide
Catalogue No.:PA 47 0141023
Molecular Formula : C30H29FIN5O9
Molecular Weight : 749.49
(2S,3S,4S,5R,6S)-6-(2-Amino-4-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic Acid
Catalogue No.:PA 47 0141024
Molecular Formula : C30H29FIN5O10
Molecular Weight : 765.49
Trametinib-13C-d3
Catalogue No.:PA STI 089834
Molecular Formula : C2513CH20D3FIN5O4
Molecular Weight : 619.41
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