Tosedostat and its Impurities

Tosedostat has been used in trials studying the treatment and supportive care of AML, Leukemia, Pancreas Cancer, Multiple Myeloma, and Pancreatic Cancer, among others. It is an inhibitor of the M1 family of aminopeptidases, in particular PuSA, and LTA4 hydrolase.Reference standards of Tosedostat API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.