Tivozanib and its Impurities

Tivozanib, sold under the brand name Fotivda, is a medication used for the treatment of relapsed or refractory advanced renal cell carcinoma. It is an oral VEGF receptor tyrosine kinase inhibitor. Reference standards of Tivozanib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.