Tiotropium and its Impurities
Tiotropium is used for maintenance treatment of chronic obstructive pulmonary disease. It is sold under the brandname Spiriva.Reference standards of Tiotropium API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


(2R,3aR,5S,6S,6aS)-6-(Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-4,4-dimethylhexahydro-2H-2,5-methanofuro[3,2-b]pyrrol-4-ium Bromide
(2R,3aR,5S,6S,6aS)-6-(Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-4,4-dimethylhexahydro-2H-2,5-methanofuro[3,2-b]pyrrol-4-ium Bromide
Catalogue No.:PA 20 66530
CAS :
NA
Molecular Formula : C19H22BrNO4S2
Molecular Weight : 472.42


(2S,3aS,5R,6R,6aR)-4-Methylhexahydro-2H-2,5-methanofuro[3,2-b]pyrrol-6-yl 2-hydroxy-2,2-di(thiophen-2-yl)Acetate
(2S,3aS,5R,6R,6aR)-4-Methylhexahydro-2H-2,5-methanofuro[3,2-b]pyrrol-6-yl 2-hydroxy-2,2-di(thiophen-2-yl)Acetate
Catalogue No.:PA 20 66560
CAS :
1459721-06-2
Molecular Formula : C18H19NO4S2
Molecular Weight : 377.48


(1R,3S,5S)-3-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-8,8-dimethyl-d3-8-azabicyclo[3.2.1]oct-6-en-8-ium Bromide_x0000_
(1R,3S,5S)-3-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-8,8-dimethyl-d3-8-azabicyclo[3.2.1]oct-6-en-8-ium Bromide_x0000_
Catalogue No.:PA STI 048700
CAS :
NA
Molecular Formula : C19H19D3BrNO3S2
Molecular Weight : 459.44

![7-[(Hydroxy-2-thienyl-3-thienylacetyl)oxy]-9,9-dim PA STI 051790](https://www.pharmaffiliates.com/pimages/PASTI051790.jpg)
7-[(Hydroxy-2-thienyl-3-thienylacetyl)oxy]-9,9-dimethyl-3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane Bromide-d6
7-[(Hydroxy-2-thienyl-3-thienylacetyl)oxy]-9,9-dimethyl-3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane Bromide-d6
Catalogue No.:PA STI 051790
CAS :
NA
Molecular Formula : C19H16D6NO4S2
Molecular Weight : 398.55


(2S,3aS,5R,6R,6aR)-6-(2-hydroxy-2,2-di(thiophen-2-yl)acetoxy)-4,4-dimethylhexahydro-2H-2,5-methanofuro[3,2-b]pyrrol-4-ium bromide
(2S,3aS,5R,6R,6aR)-6-(2-hydroxy-2,2-di(thiophen-2-yl)acetoxy)-4,4-dimethylhexahydro-2H-2,5-methanofuro[3,2-b]pyrrol-4-ium bromide
Catalogue No.:PA 20 0661001
CAS :
NA
Molecular Formula : C19H22BrNO4S2
Molecular Weight : 472.41


Propan-2-one compound with (1R,3s,5S,6S,7R)-8-methyl-8-azabicyclo[3.2.1]octane-3,6,7-triol (1:1)
Propan-2-one compound with (1R,3s,5S,6S,7R)-8-methyl-8-azabicyclo[3.2.1]octane-3,6,7-triol (1:1)
Catalogue No.:PA 20 0661008
CAS :
NA
Molecular Formula : C11H21NO4
Molecular Weight : 231.29


Rel-(2R,3aS,5R,6R,6aR)-6-hydroxy-4,4-dimethylhexahydro-2H-2,5-methanofuro[3,2-b]pyrrol-4-ium bromide
Rel-(2R,3aS,5R,6R,6aR)-6-hydroxy-4,4-dimethylhexahydro-2H-2,5-methanofuro[3,2-b]pyrrol-4-ium bromide
Catalogue No.:PA 20 0661002
CAS :
1044148-31-3
Molecular Formula : C9H16BrNO2
Molecular Weight : 250.14


(2RS,3aSR,5RS,6RS,6aRS)-6-Hydroxy-4,4-dimethylhexahydro-2H-2,5-methanofuro[3,2-b]pyrrol-4- ium Bromide
(2RS,3aSR,5RS,6RS,6aRS)-6-Hydroxy-4,4-dimethylhexahydro-2H-2,5-methanofuro[3,2-b]pyrrol-4- ium Bromide
Catalogue No.:PA 20 0661011
CAS :
NA
Molecular Formula : C9H16BrNO2
Molecular Weight : 250.14