tenofovir and its Impurities
Tenofovir disoproxil is used for HIV-1 infection and chronic hepatitis B treatment. It is available as a generic medication. It is sold under the trade name Viread.Reference standards of Tenofovir API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
(((1-(6-((((9-(2-(Phosphonomethoxy)propyl)-9H-purin-6-yl)amino)methyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic Acid
(((1-(6-((((9-(2-(Phosphonomethoxy)propyl)-9H-purin-6-yl)amino)methyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic Acid
Catalogue No.:PA 20 0091012
CAS :
NA
Molecular Formula : C19H28N10O8P2
Molecular Weight : 586.44
((Hydroxy((((R)-1-(6-(methyleneamino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)oxy)methyl isopropyl Carbonate
((Hydroxy((((R)-1-(6-(methyleneamino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)oxy)methyl isopropyl Carbonate
Catalogue No.:PA 20 0091013
CAS :
1962114-91-5
Molecular Formula : C15H22N5O7P
Molecular Weight : 415.34
Isopropyl (phenoxy(((1-(6-((3,5,6-trihydroxy-2-oxo-4-((3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)alaninate
Isopropyl (phenoxy(((1-(6-((3,5,6-trihydroxy-2-oxo-4-((3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)alaninate
Catalogue No.:PA 20 0091015
CAS :
NA
Molecular Formula : C33H49N6O15P
Molecular Weight : 800.76
(((1-(6-(((((((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(hydroxy)phosphoryl)oxy)methyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid
(((1-(6-(((((((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(hydroxy)phosphoryl)oxy)methyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid
Catalogue No.:PA 20 0091017
CAS :
NA
Molecular Formula : C19H28N10O8P2
Molecular Weight : 586.44
Isopropyl (R)-(9-(2-((bis(((isopropoxycarbonyl)oxy)methoxy)phosphoryl)methoxy)propyl)-9H-purin-6-yl)carbamate
Isopropyl (R)-(9-(2-((bis(((isopropoxycarbonyl)oxy)methoxy)phosphoryl)methoxy)propyl)-9H-purin-6-yl)carbamate
Catalogue No.:PA 20 0091021
CAS :
1244022-54-5
Molecular Formula : C23H36N5O12P
Molecular Weight : 605.54
(R)-(((((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)bis(oxy))bis(methylene) diisopropyl bis(carbonate) maleate
(R)-(((((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)bis(oxy))bis(methylene) diisopropyl bis(carbonate) maleate
Catalogue No.:PA 20 0091026
CAS :
1276030-80-8
Molecular Formula : C23H34N5O14P
Molecular Weight : 635.52
N-[[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]hydroxyphosphinyl]-D-alanine 1-Methylethyl Ester
N-[[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]hydroxyphosphinyl]-D-alanine 1-Methylethyl Ester
Catalogue No.:PA 20 0091032
CAS :
376633-26-0
Molecular Formula : C15H25N6O5P
Molecular Weight : 400.38
((((2R)-1-(6-((((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(hydroxy)phosphoryl)oxy)methyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid
((((2R)-1-(6-((((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(hydroxy)phosphoryl)oxy)methyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid
Catalogue No.:PA 20 0091034
CAS :
1962114-87-9
Molecular Formula : C19H28N10O8P2
Molecular Weight : 586.44
Ethyl ((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate
Ethyl ((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate
Catalogue No.:PA 20 0091036
CAS :
390409-48-0
Molecular Formula : C20H27N6O5P
Molecular Weight : 462.45
((((((R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(((isopropoxycarbonyl)oxy)methoxy)phosphoryl)oxy)methyl dimethylcarbamate fumarate
((((((R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(((isopropoxycarbonyl)oxy)methoxy)phosphoryl)oxy)methyl dimethylcarbamate fumarate
Catalogue No.:PA 20 0091039
CAS :
NA
Molecular Formula : C22H33N6O13P
Molecular Weight : 620.51
Isopropyl ((R)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-D-alaninate
Isopropyl ((R)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-D-alaninate
Catalogue No.:PA 20 0091044
CAS :
2053424-88-5
Molecular Formula : C21H29N6O5P
Molecular Weight : 476.47
N,N'-(((((methylenebis(azanediyl))bis(9H-purine-6,9-diyl))bis(propane-1,2-diyl))bis(oxy))bis(methylene))bis(N-(1-isopropoxy-1-oxopropan-2-yl)phosphonamidic acid)
N,N'-(((((methylenebis(azanediyl))bis(9H-purine-6,9-diyl))bis(propane-1,2-diyl))bis(oxy))bis(methylene))bis(N-(1-isopropoxy-1-oxopropan-2-yl)phosphonamidic acid)
Catalogue No.:PA 20 0091046
CAS :
NA
Molecular Formula : C31H50N12O10P2
Molecular Weight : 812.76
(((L-alanyl)oxy)((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)-L-alanine
(((L-alanyl)oxy)((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)-L-alanine
Catalogue No.:PA 20 0091052
CAS :
2007145-90-4
Molecular Formula : C15H24N7O6P
Molecular Weight : 429.37
Isopropyl ((R)-((((S)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate
Isopropyl ((R)-((((S)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate
Catalogue No.:PA 20 0091060
CAS :
NA
Molecular Formula : C21H29N6O5P
Molecular Weight : 476.47
Propyl ((R)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate
Propyl ((R)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate
Catalogue No.:PA 20 0091062
CAS :
NA
Molecular Formula : C21H29N6O5P
Molecular Weight : 476.47
Isopropyl (((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-D-alaninate
Isopropyl (((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-D-alaninate
Catalogue No.:PA 20 0091063
CAS :
2053423-98-4
Molecular Formula : C21H29N6O5P
Molecular Weight : 476.47
Ammonium (9-((2R)-2-(((((2R,5S)-5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methoxy)(hydroxy)phosphoryl)methoxy)propyl)-9H-purin-6-yl)amide
Ammonium (9-((2R)-2-(((((2R,5S)-5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methoxy)(hydroxy)phosphoryl)methoxy)propyl)-9H-purin-6-yl)amide
Catalogue No.:PA 20 0091064
CAS :
NA
Molecular Formula : C17H25FN9O6PS
Molecular Weight : 533.48
Ammonium ((isopropoxycarbonyl)oxy)methyl ((((R)-1-(6-((((5-fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)amino)methyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate
Ammonium ((isopropoxycarbonyl)oxy)methyl ((((R)-1-(6-((((5-fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)amino)methyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate
Catalogue No.:PA 20 0091065
CAS :
NA
Molecular Formula : C23H35FN9O10PS
Molecular Weight : 679.62
Methyl ((R)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate
Methyl ((R)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate
Catalogue No.:PA 20 0091066
CAS :
390409-29-7
Molecular Formula : C19H25N6O5P
Molecular Weight : 448.42
Methyl hydrogen ((((R)-1-(6-(((Z)-(5-(hydroxymethyl)furan-2-yl)methylene)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate
Methyl hydrogen ((((R)-1-(6-(((Z)-(5-(hydroxymethyl)furan-2-yl)methylene)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate
Catalogue No.:PA 20 0091068
CAS :
NA
Molecular Formula : C16H20N5O6P
Molecular Weight : 409.34
Diisopropyl 2,2'-((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)bis(azanediyl))(2S,2'S)-dipropionate fumarate
Diisopropyl 2,2'-((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)bis(azanediyl))(2S,2'S)-dipropionate fumarate
Catalogue No.:PA 20 0091043
CAS :
NA
Molecular Formula : C25H40N7O10P
Molecular Weight : 629.61
Isopropyl ((S)-((((R)-1-(6-((((2S,3S,4S,5R)-2,3-dihydroxy-5-(hydroxymethyl)-4-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydrofuran-2-yl)methyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate
Isopropyl ((S)-((((R)-1-(6-((((2S,3S,4S,5R)-2,3-dihydroxy-5-(hydroxymethyl)-4-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydrofuran-2-yl)methyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate
Catalogue No.:PA 20 0091071
CAS :
NA
Molecular Formula : C33H49N6O15P
Molecular Weight : 800.76
9-Hydroxy-2-(3-hydroxycyclopentyl)-1,8-dioxo-N-(2,4,6-trifluorobenzyl)-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxamide
9-Hydroxy-2-(3-hydroxycyclopentyl)-1,8-dioxo-N-(2,4,6-trifluorobenzyl)-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxamide
Catalogue No.:PA 20 0091072
CAS :
NA
Molecular Formula : C21H20F3N3O5
Molecular Weight : 451.4
(S)-2-Aminopropanoic (phenyl (R)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic) Anhydride
(S)-2-Aminopropanoic (phenyl (R)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic) Anhydride
Catalogue No.:PA 20 0091074
CAS :
2228092-46-2
Molecular Formula : C18H23N6O5P
Molecular Weight : 434.39
Isopropyl (((((R)-1-(6-((((9-((R)-2-(((S)-(((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)methoxy)propyl)-9H-purin-6-yl)amino)methyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate
Isopropyl (((((R)-1-(6-((((9-((R)-2-(((S)-(((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)methoxy)propyl)-9H-purin-6-yl)amino)methyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate
Catalogue No.:PA 20 0091076
CAS :
NA
Molecular Formula : C43H58N12O10P2
Molecular Weight : 964.96
Isopropyl (((((R)-1-(6-((hydroxymethyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate
Isopropyl (((((R)-1-(6-((hydroxymethyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate
Catalogue No.:PA 20 0091077
CAS :
NA
Molecular Formula : C22H31N6O6P
Molecular Weight : 506.5
N-(1-Isopropoxy-1-oxopropan-2-yl)-P-(((1-(6-(methyleneamino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonamidic Acid
N-(1-Isopropoxy-1-oxopropan-2-yl)-P-(((1-(6-(methyleneamino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonamidic Acid
Catalogue No.:PA 20 0091078
CAS :
NA
Molecular Formula : C16H25N6O5P
Molecular Weight : 412.39
Isopropyl phenyl ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate hemifumarate
Isopropyl phenyl ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate hemifumarate
Catalogue No.:PA 20 0091082
CAS :
NA
Molecular Formula : C40H52N10O12P2
Molecular Weight : 926.86
((((((R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(((isopropoxycarbonyl)oxy)methoxy)phosphoryl)oxy)methyl 2-ethylbutanoate
((((((R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(((isopropoxycarbonyl)oxy)methoxy)phosphoryl)oxy)methyl 2-ethylbutanoate
Catalogue No.:PA 20 0091085
CAS :
1246812-23-6
Molecular Formula : C21H34N5O9P
Molecular Weight : 531.5
P-((((R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)-N-((S)-1-isopropoxy-1-oxopropan-2-yl)phosphonamidic Acid, Ammonia Salt
P-((((R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)-N-((S)-1-isopropoxy-1-oxopropan-2-yl)phosphonamidic Acid, Ammonia Salt
Catalogue No.:PA 20 0091088
CAS :
NA
Molecular Formula : C15H28N7O5P
Molecular Weight : 417.41
Lithium P-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)-N-((S)-1-isopropoxy-1-oxopropan-2-yl)phosphonamidate
Lithium P-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)-N-((S)-1-isopropoxy-1-oxopropan-2-yl)phosphonamidate
Catalogue No.:PA 20 0091089
CAS :
NA
Molecular Formula : C15H24LiN6O5P
Molecular Weight : 406.31
Isopropyl (((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-D-alaninate Fumarate
Isopropyl (((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-D-alaninate Fumarate
Catalogue No.:PA 20 0091090
CAS :
2053427-57-7
Molecular Formula : C25H33N6O9P
Molecular Weight : 592.55
