A macrolide lactone, Tacrolimus is an immunosupressant drug. Tacrolimus is a macrolide calcineurin inhibitor used mainly after allogeneic organ transplant to lower the risk of organ rejection. Topical ointment is used to treat severe cases of atopic dermatitis (eczema)Reference standards of Tacrolimus API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Tacrolimus
Catalogue No.:PA 20 67000
CAS :
Molecular Formula : C44H69NO12
Molecular Weight : 804.02
(E)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(E)-2-(4-hydroxy-3-methoxycyclohexyl)-1-methylvinyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21-(4H,23H)-tetrone
Catalogue No.:PA 20 01730
Molecular Formula : C43H69NO12
Molecular Weight : 792.02
Tacrolimus Open Ring
Catalogue No.:PA 20 01520
Molecular Formula : C44H71NO13
Molecular Weight : 822.05
19-Epi Ascomycin
Catalogue No.:PA 20 01530
Molecular Weight : 792.01
(E/Z)-FK-506 26,28-Allylic Ester Rearrangement Impurity
Catalogue No.:PA 20 01550
Molecular Weight : 804.04
Tacrolimus Diene
Catalogue No.:PA 20 01560
Molecular Formula : C44H67NO11
Molecular Weight : 786
15-O-Desmethyl Tacrolimus
Catalogue No.:PA 20 01570
Molecular Formula : C43H67NO12
Molecular Weight : 789.99
Tacrolimus 31 DMT
Catalogue No.:PA 20 01580
Tacrolimus 13 DMT
Catalogue No.:PA 20 01590
Tacrolimus Hydroxy Acid Impurity
Catalogue No.:PA 20 01600
Molecular Weight : 822.03
Tacrolimus compound II
Catalogue No.:PA 20 01610
Tacrolimus Lactone Isomer
Catalogue No.:PA 20 01620
Tacrolimus Methyl Acryl Aldehyde
Catalogue No.:PA 20 01630
Molecular Formula : C11H18O3
Molecular Weight : 198.26
Tacrolimus 21-Carboxy Acid
Catalogue No.:PA 20 01640
Molecular Weight : 822.06
15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-oxocyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, [3S-[3R*[E(1S*,4R*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]
Catalogue No.:PA 20 01650
Molecular Formula : C43H65NO12
Molecular Weight : 787.98
15,19:20,23-Diepoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,21(4H,8H,23H)-trione, 5,6,11,12,13,14,15,16,17,18,19,20,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)
Catalogue No.:PA 20 01660
Tacrolimus Regioisomer
Catalogue No.:PA 20 01670
9-Norketo FK-506
Catalogue No.:PA 20 01680
Molecular Formula : C43H69NO11
Molecular Weight : 776.01
13-O-Desmethylated Tacrolimus
Catalogue No.:PA 20 01690
24,32-Bis-O-(tert-butyldimethylsilyl)-FK-506-13C, D2 (Major)
Catalogue No.:PA STI 013110
Molecular Formula : C5513CH95D2NO12Si2
Molecular Weight : 1035.54
FK-506-13C,D2 (Major) (Tacrolimus)
Catalogue No.:PA STI 041210
Molecular Formula : C4313CH67D2NO12
Molecular Weight : 807.02
(S)-1-(2-((2R,3R,5S,6R)-6-((1S,3S,5E,7R,10S,11R,12S,13E)-7-Allyl-10,12-dihydroxy-14-((1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-1-methoxy-3,5,11,13-tetramethyl-8-oxotetradeca-5,13-dien-1-yl)-2-hydroxy-5-methoxy-3-methyltetrahydro-2H-pyran-2-yl)-2-oxoacetyl)piperidine-2-carboxylic Acid
Catalogue No.:PA 20 01710
31-O-Demethyltacrolimus
Catalogue No.:PA 20 01720
Molecular Weight : 790
Tacrolimus (JP 0221)
Catalogue No.:PA JP0221
Molecular Formula : NA
Molecular Weight : NA
Tacrolimus monohydrate (Y0001926)
Catalogue No.:PA EPY0001926
Tacrolimus for system suitability (Y0001933)
Catalogue No.:PA EPY0001933
Catalogue No.:PA USP1642802
Molecular Formula :
Catalogue No.:PA USP1642813
Catalogue No.:PA USP1642824
Catalogue No.:PA USP1642835
Catalogue No.:PA USP1642857
24-O-Triisopropylsilyl 9-Norketo FK-506
Catalogue No.:PA 20 01740
Molecular Formula : C52H89NO11Si
Molecular Weight : 932.35
(3S,4R,5S,8R,12S,14S,15R,16S,18R,26aS,Z)-8-Allyl-5,15-dihydroxy-3-((E)-1-((1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl)prop-1-en-2-yl)-14,16-dimethoxy-4,10,12,18-tetramethyl-5,6,11,12,13,14,15,16,17,18,24,25,26,26a-tetradecahydro-3H-pyrido[2,1-c][1]oxa[4]azacyclotricosine-1,7,19,20,21(4H,8H,23H)-pentaone
Catalogue No.:PA 20 01750
Molecular Weight : 804.03
24,33-bis-O-(tert-Butyldimethylsilyl) Tacrolimus
Catalogue No.:PA 20 01760
Molecular Formula : C56H97NO12Si2
Molecular Weight : 1032.56
24,33-bis-O-(tert-Butyldimethylsilyl)-37,38-dehydro-37,38-dihydroxy-FK-506 (Mixture of Diastereomers)
Catalogue No.:PA 20 01770
Molecular Formula : C56H99NO14Si2
Molecular Weight : 1066.57
33-tert-Butyldimethylsilyloxy-FK 506
Catalogue No.:PA 20 01780
Molecular Formula : C50H83NO12Si
Molecular Weight : 918.29
Tacrolimus System Suitability Mixture
Catalogue No.:PA 20 0671000
Tacrolimus-13CD4
Catalogue No.:PA STI 089131
Molecular Formula : C4313CH65D4NO12
Molecular Weight : 809.05
Tacrolimus Dehydro Impurity
Catalogue No.:PA 20 0671001
Molecular Weight : 786.02
Tacrolimus Diene Impurity Mixture of 8R, 8S Isomer
Catalogue No.:PAI 20 067001
13-O-Desmethyl Tacrolimus
Catalogue No.:PA 20 0671002
5,6,11,13,14,15,16,17,18,20,24,25,26,26a-Tetradecahydro-5,15,20-trihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-17,20-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,19,21(4H,8H,12H,23H)-tetrone
Catalogue No.:PA 20 0671003
Molecular Formula : C44H69NO13
Molecular Weight : 820.03
Tacrolimus-32-Succinate
Catalogue No.:PA 20 0671007
Molecular Formula : C48H73NO15
Molecular Weight : 904.1
12-Hydroxyl Tacrolimus
Catalogue No.:PA 20 0671006
13, 31-O-Didesmethyl Tacrolimus
Catalogue No.:PA 20 0671005
Molecular Formula : C42H65NO12
Molecular Weight : 775.98
13,15-O-Didesmethyl Tacrolimus
Catalogue No.:PA 20 0671004
Tacrolimus 24 Succinate
Catalogue No.:PA 20 0671008
Tacrolimus C4-epimer Diene
Catalogue No.:PA 20 0671009
Tacrolimus Impurity 1
Catalogue No.:PA 20 0671010
Molecular Weight : 776.02
(3S,4R,5S,8R,12S,14S,15R,16S,18R,19R,26aS,E)-5,19-Dihydroxy-3-((E)-1-((1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl)prop-1-en-2-yl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-methylallyl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1]oxa[4]azacyclotricosine-1,7,20,21(4H,23H)-tetraone
Catalogue No.:PA 20 0671011
Molecular Formula : C45H71NO12
Molecular Weight : 818.06
(3S,4R,5S,8R,12S,14S,15R,16S,18R,19R,25aS,E)-8-Allyl-5,19-Dihydroxy-3-((E)-1-((1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl)prop-1-en-2-yl)-14,16-dimethoxy-4,10,12,18-tetramethyl-3,4,5,6,8,11,12,13,14,15,16,17,18,19,23,24,25,25a-octadecahydro-15,18-(epoxymethano)pyrido[2,1-c][1]oxa[4]azacyclodocosine-1,7,20,26(22H)-tetraone
Catalogue No.:PA 20 0671012
Tacrolimus O-ethyl open ring (peak 1)
Catalogue No.:PA 20 0671013
Molecular Formula : C46H75NO13
Molecular Weight : 850.1
Tacrolimus O-ethyl open ring (peak 2)
Catalogue No.:PA 20 0671014
Tacrolimus 20-ethoxy acetal
Catalogue No.:PA 20 0671015
Molecular Weight : 850.10
15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-propyl
Catalogue No.:PA 20 0671016
Molecular Formula : C44H71NO12
Molecular Weight : 806.05
(3S,4R,5S,8R,12S,14S,15R,16S,18R,19R,26aS,Z)-8-Allyl-5,19-dihydroxy-3-((E)-1-((1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl)prop-1-en-2-yl)-14,16-dimethoxy-4,10,12,18-tetramethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1]oxa[4]azacyclotricosine-1,7,20,21(4H,23H)-tetraone
Catalogue No.:PA 20 0671017
(3S,4R,5S,8S,12R,14R,15S,16S,18R,25aR,Z)-8-Allyl-5,19-dihydroxy-3-((E)-1-((1R,4R)-4-hydroxy-3-methoxycyclohexyl)prop-1-en-2-yl)-14,16-dimethoxy-4,10,12,18-tetramethyl-3,4,5,6,8,11,12,13,14,15,16,17,18,19,23,24,25,25a-octadecahydro-15,18-(epoxymethano)pyrido[2,1-c][1]oxa[4]azacyclodocosine-1,7,20,26(22H)-tetraone
Catalogue No.:PA 20 0671018
(3S,6R,10S,12S,13R,14S,16R,17R,24aS,E)-6-Allyl-17-hydroxy-3-((2S,3S,E)-3-hydroxy-5-((1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-4-methylpent-4-en-2-yl)-12,14-dimethoxy-8,10,16-trimethyl-6,9,10,11,12,13,14,15,16,17,22,23,24,24a-tetradecahydro-3H-13,17-epoxypyrido[2,1-c][1]oxa[4]azacyclohenicosine-1,5,18,19(4H,21H)-tetraone
Catalogue No.:PA 20 0671019
(3S,4E,6S,7S,10R,11E,14S,16S,17R,18S,20R,21R,28aS)-10-Allyl-7,21-dihydroxy-3-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-16,18-dimethoxy-4,6,12,14,20-pentamethyl-7,8,10,13,14,15,16,17,18,19,20,21,26,27,28,28a-hexadecahydro-3H-17,21-epoxypyrido[2,1-c][1]oxa[4]azacyclopentacosine-1,9,22,23(6H,25H)-tetraone
Catalogue No.:PA 20 0671020
11,15-Epoxy-4,6-(epoxymethano)-2H,7H-pyrano[3,2-r]pyrido[2,1-c][1,4]oxaazacyclotricosine-16,17,23(19H)-trione, 25-[(1E)-2-[(1R,3R,4R)-3,4-dihydroxycyclohexyl]-1-methylethenyl]-3,4,4a,8,9,10,11,12,13,14,15,20,21,22,22a,25,26,27,28,28a-eicosahydro-15,27,28a-trihydroxy-10,12-dimethoxy-8,14,26-trimethyl-, (8S,10S,11R,12S,14R,15R,22aS,25S,26R,27S)
Catalogue No.:PA 20 0671021
Molecular Formula : C43H67NO14
Molecular Weight : 822.00
(3S,4R,5S,8R,12S,14S,15R,16S,18R,19S,26aS,E)-8-Allyl-20-ethoxy-5,19,20-trihydroxy-3-((E)-1-((1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl)prop-1-en-2-yl)-14,16-dimethoxy-4,10,12,18-tetramethyl-3,4,5,6,11,12,13,14,15,16,17,18,19,20,24,25,26,26a-octadecahydro-7H-15,19-epoxypyrido[2,1-c][1]oxa[4]azacyclotricosine-1,7,21(8H,23H)-trione
Catalogue No.:PA 20 0671022
(3S,4R,5S,8R,12S,14S,15R,16S,18R,20R,26aS,E)-8-Allyl-20-ethoxy-5,15,20-trihydroxy-3-((E)-1-((1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl)prop-1-en-2-yl)-14,16-dimethoxy-4,10,12,18-tetramethyl-3,4,5,6,11,12,13,14,15,16,17,18,24,25,26,26a-hexadecahydro-7H-pyrido[2,1-c][1]oxa[4]azacyclotricosine-1,7,19,21(8H,20H,23H)-tetraone
Catalogue No.:PA 20 0671023
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