saxagliptin and its Impurities
Saxagliptin is used as monotherapy or in combination with other drugs for the treatment of type 2 diabetes. It is an oral hypoglycemic SaxagliptinIt, it is sold under the brand name Onglyza.Reference standards of Saxagliptin API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


(1S,3S,5S)-2-((S)-2-amino-2-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic Acid
(1S,3S,5S)-2-((S)-2-amino-2-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic Acid
Catalogue No.:PA 19 40740
CAS :
1802786-89-5
Molecular Formula : C18H26N2O4
Molecular Weight : 334.41

![N-((S)-2-((1S,3S,5S)-3-Cyano-2-azabicyclo[3.1.0]he PA 19 40750](https://www.pharmaffiliates.com/pimages/PA1940750.jpg)
N-((S)-2-((1S,3S,5S)-3-Cyano-2-azabicyclo[3.1.0]hexan-2-yl)-1-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)acetamide
N-((S)-2-((1S,3S,5S)-3-Cyano-2-azabicyclo[3.1.0]hexan-2-yl)-1-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)acetamide
Catalogue No.:PA 19 40750
CAS :
NA
Molecular Formula : C20H28N2O5
Molecular Weight : 376.45


(1S,3S,5S)-2-((2S)-2-Amino-2-(3-(trichloromethoxy)adamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile
(1S,3S,5S)-2-((2S)-2-Amino-2-(3-(trichloromethoxy)adamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile
Catalogue No.:PA 19 40760
CAS :
NA
Molecular Formula : C19H24Cl3N3O2
Molecular Weight : 432.77


(R)-2-((S)-2-((1S,3S,5S)-3-Cyano-2-azabicyclo[3.1.0]hexan-2-yl)-1-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)succinic Acid
(R)-2-((S)-2-((1S,3S,5S)-3-Cyano-2-azabicyclo[3.1.0]hexan-2-yl)-1-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)succinic Acid
Catalogue No.:PA 19 40780
CAS :
NA
Molecular Formula : C22H28N2O6
Molecular Weight : 416.47


(1S,3R,5S)-2-((2S)-2-Amino-2-(3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carboxamide
(1S,3R,5S)-2-((2S)-2-Amino-2-(3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carboxamide
Catalogue No.:PA 19 40830
CAS :
NA
Molecular Formula : C18H27N3O3
Molecular Weight : 333.43


3-((S)-1-Amino-2-((1S,3R,5S),-3-cyano-2-aza-biclyclo[3.1.0]hexan-2-yl)-2-oxoethyl)adamantan-1-yl-2,2,2-trichloroacetate
3-((S)-1-Amino-2-((1S,3R,5S),-3-cyano-2-aza-biclyclo[3.1.0]hexan-2-yl)-2-oxoethyl)adamantan-1-yl-2,2,2-trichloroacetate
Catalogue No.:PA 19 40840
CAS :
NA
Molecular Formula : C20H24Cl3N3O3
Molecular Weight : 460.78


(1aS,4S,6aR,7aS)-6-Amino-4-(3,5-dihydroxytricyclo[3.3.1.13,7]dec-1-yl)-1,1a,4,6a,7,7a-hexahydro-3H-cyclopropa[4,5]pyrrolo[1,2-a]pyrazin-3-one
(1aS,4S,6aR,7aS)-6-Amino-4-(3,5-dihydroxytricyclo[3.3.1.13,7]dec-1-yl)-1,1a,4,6a,7,7a-hexahydro-3H-cyclopropa[4,5]pyrrolo[1,2-a]pyrazin-3-one
Catalogue No.:PA 19 40920
CAS :
1429782-93-3
Molecular Formula : C18H25N3O3
Molecular Weight : 331.41


(1S,3S,5S)-2-((R)-2-Amino-2-((1r,3S,5R,7S)-3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride
(1S,3S,5S)-2-((R)-2-Amino-2-((1r,3S,5R,7S)-3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride
Catalogue No.:PA 19 0401003
CAS :
NA
Molecular Formula : C18H26ClN3O2
Molecular Weight : 351.88


(1S,3R,5S)-2-((2S)-2-Amino-2-(3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride
(1S,3R,5S)-2-((2S)-2-Amino-2-(3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride
Catalogue No.:PA 19 0401004
CAS :
NA
Molecular Formula : C18H26ClN3O2
Molecular Weight : 351.88


(E)-4-(((1S)-2-((1S,3S,5S)-3-Cyano-2-azabicyclo[3.1.0]hexan-2-yl)-1-((3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)amino)-4-oxobut-2-enoic acid
(E)-4-(((1S)-2-((1S,3S,5S)-3-Cyano-2-azabicyclo[3.1.0]hexan-2-yl)-1-((3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)amino)-4-oxobut-2-enoic acid
Catalogue No.:PA 19 0401017
CAS :
NA
Molecular Formula : C22H27N3O5
Molecular Weight : 413.47


(1S,3S,5S)-2-((2S)-2-(((3R,4R,6R)-3,4-Dihydroxy-6-(hydroxymethyl)-5-(((3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)amino)-2-((3R,5R,7S)-3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile
(1S,3S,5S)-2-((2S)-2-(((3R,4R,6R)-3,4-Dihydroxy-6-(hydroxymethyl)-5-(((3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)amino)-2-((3R,5R,7S)-3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile
Catalogue No.:PA 19 0401018
CAS :
NA
Molecular Formula : C30H45N3O12
Molecular Weight : 639.3


(1R,3S,5R)-2-((2S)-2-(3-Hydroxyadamantan-1-yl)-2-(tritylamino)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile
(1R,3S,5R)-2-((2S)-2-(3-Hydroxyadamantan-1-yl)-2-(tritylamino)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile
Catalogue No.:PA 19 0401026
CAS :
NA
Molecular Formula : C37H39N3O2
Molecular Weight : 557.74


(1R,3r,5R,7S)-3-((S)-1-((tert-Butoxycarbonyl)amino)-2-((1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)adamantan-1-yl 2,2,2-trifluoroacetate
(1R,3r,5R,7S)-3-((S)-1-((tert-Butoxycarbonyl)amino)-2-((1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)adamantan-1-yl 2,2,2-trifluoroacetate
Catalogue No.:PA 19 0401028
CAS :
1194836-75-3
Molecular Formula : C25H32F3N3O5
Molecular Weight : 511.54


(1aS,4S,7aS)-4-((1r,3R,5R,7S)-3-Hydroxyadamantan-1-yl)-6-imino-5-nitrosooctahydro-3H-cyclopropa[4,5]pyrrolo[1,2-a]pyrazin-3-one
(1aS,4S,7aS)-4-((1r,3R,5R,7S)-3-Hydroxyadamantan-1-yl)-6-imino-5-nitrosooctahydro-3H-cyclopropa[4,5]pyrrolo[1,2-a]pyrazin-3-one
Catalogue No.:PA 19 0401029
CAS :
NA
Molecular Formula : C18H24N4O3
Molecular Weight : 344.42