An antihypertensive drug, Sacubitril is used in combination with valsartan for the treatment of heart ailments. A prodrug of sacubitrilat which is an inhibitor of enzyme neprilysin, which aids the degradation of blood pressure-lowering peptides, atrial and brain natriuretic peptide.Reference standards of Sacubitril API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Sacubitril
Catalogue No.:PA 19 66000
CAS :
Molecular Formula : C24H29NO5
Molecular Weight : 411.49
(2S,4R)-Sacubitril
Catalogue No.:PA 19 66510
(2R,4S)-2-Methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-(4-phenylphenyl)pentanoic Acid
Catalogue No.:PA 19 66520
Molecular Formula : C23H29NO4
Molecular Weight : 383.48
(2S,4R)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic Acid
Catalogue No.:PA 19 66530
(2S,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic Acid
Catalogue No.:PA 19 66540
(αR,γR)-γ-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic Acid
Catalogue No.:PA 19 66550
(2S,4S)-Sacubitril
Catalogue No.:PA 19 66560
(2R,4R)-Sacubitril
Catalogue No.:PA 19 66570
Sacubitrilat
Catalogue No.:PA 19 66580
Molecular Formula : C22H25NO5
Molecular Weight : 383.44
Sacubitril mixture with Valsartan
Catalogue No.:PA 19 66600
Molecular Formula : C48H58N6O8
Molecular Weight : 847.01
Sacubitril Calcium
Catalogue No.:PA 19 66610
Molecular Formula : C24H28NO5 ·0.5Ca
Molecular Weight : 430.52
Sacubitril (3R,5S)-Pyrrolidinone Impurity
Catalogue No.:PA 19 66620
Molecular Formula : C18H19NO
Molecular Weight : 265.35
(R,E)-5-([1,1-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic Acid
Catalogue No.:PA 19 66630
Molecular Formula : C24H29NO3
Molecular Weight : 379.5
(R,E)-Ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoate
Catalogue No.:PA 19 66640
Molecular Formula : C25H31NO4
Molecular Weight : 409.53
Sacubitril-d4
Catalogue No.:PA STI 078661
Molecular Formula : C24H25D4NO5
Molecular Weight : 415.52
Methyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate Hydrochloride
Catalogue No.:PA 19 66650
Molecular Formula : C19H24ClNO2
Molecular Weight : 333.86
(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride
Catalogue No.:PA 19 66660
Molecular Formula : C20H26ClNO2
Molecular Weight : 347.88
Ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoate
Catalogue No.:PA 19 66670
Molecular Formula : C25H33NO4
Molecular Weight : 411.54
(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-amino-2-methylpentanoic Acid Hydrochloride
Catalogue No.:PA 19 66680
Molecular Formula : C18H22ClNO2
Molecular Weight : 319.83
Ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-acetamido-2-methylpentanoate
Catalogue No.:PA 19 66690
Molecular Formula : C22H27NO3
Molecular Weight : 353.46
2,5-Dioxopyrrolidine Sacubitril
Catalogue No.:PA 19 66700
Molecular Formula : C24H27NO4
Molecular Weight : 393.48
((R)-2-Biphenyl-4-yl-1-formylethyl)carbamic Acid t-butyl Ester
Catalogue No.:PA 19 66710
Molecular Formula : C20H23NO3
Molecular Weight : 325.41
(R)-tert-Butyl (1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate
Catalogue No.:PA 19 66720
Molecular Formula : C20H25NO3
Molecular Weight : 327.42
4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-methoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic Acid
Catalogue No.:PA 19 66730
Molecular Formula : C23H27NO5
Molecular Weight : 397.47
4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-4-methyl-5-oxo-5-propoxypentan-2-yl)amino)-4-oxobutanoic Acid
Catalogue No.:PA 19 66740
Molecular Formula : C25H31NO5
Molecular Weight : 425.53
(2R,4S)-Ethyl 5-([1,1'-biphenyl]-4-yl)-4-(4-ethoxy-4-oxobutanamido)-2-methylpentanoate
Catalogue No.:PA 19 0661000
Molecular Formula : C26H33NO5
Molecular Weight : 439.55
Sacubitril (3S,5S)-Pyrrolidinone
Catalogue No.:PA 19 0661001
Molecular Weight : 265.36
(S)-1-([1,1'-Biphenyl]-4-yl)-3-(benzyloxy)propan-2-ol
Catalogue No.:PA 19 0661002
Molecular Formula : C22H22O2
Molecular Weight : 318.42
(R)-2-(1-([1,1'-Biphenyl]-4-yl)-3-(benzyloxy)propan-2-yl)isoindoline-1,3-dione
Catalogue No.:PA 19 0661003
Molecular Formula : C30H25NO3
Molecular Weight : 447.53
(R)-1-([1,1'-Biphenyl]-4-yl)-3-(benzyloxy)propan-2-amine Hydrochloride
Catalogue No.:PA 19 0661004
Molecular Formula : C22H24ClNO
Molecular Weight : 353.89
tert-Butyl (R)-(1-([1,1'-biphenyl]-4-yl)-3-(benzyloxy)propan-2-yl)carbamate
Catalogue No.:PA 19 0661005
Molecular Formula : C27H31NO3
Molecular Weight : 417.55
(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-2-methyl-4-nitropentanoic Acid
Catalogue No.:PA 19 0661006
Molecular Formula : C18H19NO4
Molecular Weight : 313.35
Ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate
Catalogue No.:PA 19 0661007
Molecular Formula : C20H25NO2
Molecular Weight : 311.43
Sacubitril Maleic Acid (E-Isomer)
Catalogue No.:PA 19 0661008
Molecular Formula : C24H27NO5
Molecular Weight : 409.48
(2E,4S)-5-[1,1'-Biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-pentenoic Acid
Catalogue No.:PA 19 0661010
Molecular Formula : C23H27NO4
Molecular Weight : 381.47
(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-(4-isopropoxy-4-oxobutanamido)-2-methylpentanoic acid
Catalogue No.:PA 19 0661011
(2R,4S)-Isopropyl 5-([1,1'-biphenyl]-4-yl)-4-(4-isopropoxy-4-oxobutanamido)-2-methylpentanoate
Catalogue No.:PA 19 0661012
Molecular Formula : C28H37NO5
Molecular Weight : 467.61
Ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(4-isopropoxy-4-oxobutanamido)-2-methylpentanoate
Catalogue No.:PA 19 0661013
Molecular Formula : C27H35NO5
Molecular Weight : 453.58
(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-(4-ethoxy-4-oxobutanamido)-2-methylpentanoic acid
Catalogue No.:PA 19 0661014
Molecular Weight : 411.5
Isopropyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoate
Catalogue No.:PA 19 0661015
Molecular Formula : C25H29NO4
Molecular Weight : 407.51
(R,E)-5-([1,1'-Biphenyl]-4-yl)-4-amino-2-methylpent-2-enoic acid
Catalogue No.:PA 19 0661016
Molecular Formula : C18H19NO2
Molecular Weight : 281.36
Ethyl (2R,4R)-5-([1,1'-biphenyl]-4-yl)-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoate
Catalogue No.:PA 19 0661017
Isopropyl 4-((3R,5S)-5-([1,1'-biphenyl]-4-ylmethyl)-3-methyl-2-oxopyrrolidin-1-yl)-4-oxobutanoate
Catalogue No.:PA 19 0661018
(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoic acid
Catalogue No.:PA 19 0661019
Molecular Formula : C22H23NO4
Molecular Weight : 365.43
4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-isopropoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid
Catalogue No.:PA 19 0661020
Ethyl (R,E)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpent-2-enoate hydrochloride
Catalogue No.:PA 19 0661009
Molecular Formula : C20H24ClNO2
Molecular Weight : 345.87
(2S,4S)-Sacubitril Calcium Salt
Catalogue No.:PA 19 0661022
Molecular Formula : C48H56CaN2O10
Molecular Weight : 861.06
(E)-(R)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methyl-pent-2-enoic Acid Ethyl Ester
Catalogue No.:PA 19 0661023
Valsartan Sacubitril Sodium Hemipentahydrate Salt
Catalogue No.:PA 19 0661024
Molecular Formula : C48H58N6O8.5/2H2O.3Na
Molecular Weight : 411.5 + 435.5 + 3(23.0) + 5/2(18.0)
Sacubitril D4 Calcium Salt
Catalogue No.:PA STI 089048
Molecular Formula : C48H48D8CaN2O10
Molecular Weight : 869.11
2-Methylpropan-2-aminium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-methoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
Catalogue No.:PA 19 0661025
Molecular Formula : C27H38N2O5
Molecular Weight : 470.61
2-Methylpropan-2-aminium (Z)-4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobut-2-enoate
Catalogue No.:PA 19 0661026
Molecular Formula : C28H38N2O5
Molecular Weight : 482.62
2-Methylpropan-2-aminium 4-(((2S,4S)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
Catalogue No.:PA 19 0661027
Molecular Formula : C28H40N2O5
Molecular Weight : 484.64
2-Methylpropan-2-aminium 4-(((2R,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
Catalogue No.:PA 19 0661028
(4S)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic Acid
Catalogue No.:PA 19 0661029
Molecular Weight : 383.49
(R)-1-(1-([1,1'-Biphenyl]-4-yl)-3-chloropropan-2-yl)pyrrolidine-2,5-dione
Catalogue No.:PA 19 0661030
Molecular Formula : C19H18ClNO2
Molecular Weight : 327.81
tert-Butyl (S)-(1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate
Catalogue No.:PA 19 0661031
(R,E)-5-([1,1'-Biphenyl]-4-yl)-4-(3-carboxypropanamido)-2-methylpent-2-enoic Acid
Catalogue No.:PA 19 0661021
Molecular Formula : C22H23NO5
Molecular Weight : 381.43
(2R,4R)-Sacubitril Calcium Salt
Catalogue No.:PA 19 0661032
(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-amino-2-methylpentanoic Acid
Catalogue No.:PA 19 0661033
Molecular Formula : C18H21NO2
Molecular Weight : 283.37
rel.4-(((2R,4R)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic Acid
Catalogue No.:PA 19 0661034
Sacubitril Lactam
Catalogue No.:PA 19 0661035
N-Nitroso Sacubitril
Catalogue No.:PA 19 0661036
Molecular Formula : C24H28N2O6
Molecular Weight : 440.5
(R)-3-([1,1'-Biphenyl]-4-yl)-2-aminopropan-1-ol Hydrochloride
Catalogue No.:PA 19 0661038
Molecular Formula : C15H18ClNO
Molecular Weight : 263.77
Sacubitril Maleic Acid (Z-Isomer)
Catalogue No.:PA 19 0661039
tert-Butyl (R)-(1-([1,1'-biphenyl]-4-yl)-3-bromopropan-2-yl)carbamate
Catalogue No.:PA 19 0661040
Molecular Formula : C20H24BrNO2
Molecular Weight : 390.32
(4R)-3-Benzyl-4-propionylpyrrolidine-2,5-dione
Catalogue No.:PA 19 0661041
Molecular Formula : C14H15NO3
Molecular Weight : 245.28
Ethyl (2S,4R)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate Hydrochloride
Catalogue No.:PA 19 0661042
Ethyl (2S,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate Hydrochloride
Catalogue No.:PA 19 0661043
Ethyl (2R,4R)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate Hydrochloride
Catalogue No.:PA 19 0661044
(2Z,4R)-5-[1,1′-Biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-pentenoic Acid
Catalogue No.:PA 19 0661045
Ethyl (R)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoate
Catalogue No.:PA 19 0661046
Methyl (R)-3-([1,1'-biphenyl]-4-yl)-2-acetamidopropanoate
Catalogue No.:PA 19 0661047
Molecular Formula : C18H19NO3
Molecular Weight : 297.35
Methyl (R)-3-([1,1'-biphenyl]-4-yl)-2-((tert-butoxycarbonyl)amino)propanoate
Catalogue No.:PA 19 0661048
Molecular Formula : C21H25NO4
Molecular Weight : 355.43
tert-Butyl (R)-(3-([1,1'-biphenyl]-4-yl)-1-hydrazinyl-1-oxopropan-2-yl)carbamate
Catalogue No.:PA 19 0661049
Molecular Formula : C20H25N3O3
Molecular Weight : 355.44
Boc-D-4,4'-biphenylalanine
Catalogue No.:PA 19 0661050
Molecular Formula : C20H23NO4
Molecular Weight : 341.41
(1-Ethoxy-1-oxopropan-2-yl)triphenylphosphonium Bromide
Catalogue No.:PA 19 0661051
Molecular Formula : C23H24BrO2P
Molecular Weight : 443.32
rel-Ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-acetamido-2-methylpentanoate
Catalogue No.:PA 19 0661052
5-([1,1'-Biphenyl]-4-ylmethyl)-3-methyl-1-nitrosopyrrolidin-2-one
Catalogue No.:PA 19 0661055
Molecular Formula : C18H18N2O2
Molecular Weight : 294.35
5-([1,1'-Biphenyl]-4-ylmethyl)-3-methylpyrrolidin-2-one
Catalogue No.:PA 19 0661053
Methyl (Z)-3-([1,1'-biphenyl]-4-yl)-2-acetamidoacrylate
Catalogue No.:PA 19 0661054
Molecular Formula : C18H17NO3
Molecular Weight : 295.34
Ethyl (S,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoate
Catalogue No.:PA 19 0661056
(R)-3-([1,1'-Biphenyl]-4-yl)-2-aminopropan-1-ol
Catalogue No.:PA 19 0661057
Molecular Formula : C15H17NO
Molecular Weight : 227.31
Calcium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-methoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
Catalogue No.:PA 19 0661058
Molecular Formula : C46H54CaN2O10
Molecular Weight : 835.02
Methyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoate
Catalogue No.:PA 19 0661059
Molecular Formula : C23H25NO4
Molecular Weight : 379.46
Propyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoate
Catalogue No.:PA 19 0661060
2-Methylpropan-2-aminium 4-(((2R,4S)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
Catalogue No.:PA 19 0661061
(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-(3-carboxy-N-nitrosopropanamido)-2-methylpentanoic Acid
Catalogue No.:PA 19 0661062
Molecular Formula : C22H24N2O6
Molecular Weight : 412.44
(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)(nitroso)amino)-2-methylpentanoic Acid
Catalogue No.:PA 19 0661063
Molecular Formula : C23H28N2O5
Molecular Weight : 412.49
Ethyl (2S,4R)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate
Catalogue No.:PA 19 0661064
Ethyl (2R,4R)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate
Catalogue No.:PA 19 0661065
Ethyl (2S,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate
Catalogue No.:PA 19 0661066
tert-Butyl (1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate
Catalogue No.:PA 19 0661067
Ethyl (2S,4R)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoate
Catalogue No.:PA 19 0661068
Ethyl (2R,4R)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoate
Catalogue No.:PA 19 0661069
tert-Butyl (S)-(1-([1,1'-biphenyl]-4-yl)-3-oxopropan-2-yl)carbamate
Catalogue No.:PA 19 0661070
(R)-2-(tert-Butylamino)-3-(4-iodophenyl)propan-1-ol
Catalogue No.:PA 19 0661071
Molecular Formula : C13H20INO
Molecular Weight : 333.21
(S)-5-([1,1'-Biphenyl]-4-ylmethyl)pyrrolidin-2-one
Catalogue No.:PA 19 0661072
Molecular Formula : C17H17NO
Molecular Weight : 251.33
5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic Acid
Catalogue No.:PA 19 0661073
Ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoate
Catalogue No.:PA 19 0661074
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