Roflumilast is used in the prevention of lung attacks in severe COPD. It is a long-acting inhibitor of the enzyme phosphodiesterase-4 (PDE-4).Reference standards of Roflumilast API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Roflumilast
Catalogue No.:PA 18 15000
CAS :
Molecular Formula : C17H14Cl2F2N2O3
Molecular Weight : 403.21
5-Dechloro Roflumilast
Catalogue No.:PA 18 15510
Molecular Formula : C17H15ClF2N2O3
Molecular Weight : 368.76
3-O-Decyclopropyl Roflumilast
Catalogue No.:PA 18 15520
Molecular Formula : C13H8Cl2F2N2O3
Molecular Weight : 349.12
Roflumilast N-Oxide
Catalogue No.:PA 18 15530
Molecular Formula : C17H14Cl2F2N2O4
Molecular Weight : 419.21
Roflumilast Carboxylic Acid Impurity
Catalogue No.:PA 18 15540
Molecular Formula : C12H12F2O4
Molecular Weight : 258.22
4-Amino-3,5-dichloropyridine
Catalogue No.:PA 18 15550
Molecular Formula : C5H4Cl2N2
Molecular Weight : 163
3-(Cyclobutoxy-N-(3,5-dichloropyridin-4-yl))-4-(difluoromethoxy)benzamide
Catalogue No.:PA 18 15560
3,4-Di(cyclopropylmethoxy) Roflumilast
Catalogue No.:PA 18 15570
Molecular Formula : C20H20Cl2N2O3
Molecular Weight : 407.29
4-(Cyclopropylmethoxy)-3-(difluoromethoxy) Roflumilast
Catalogue No.:PA 18 15580
3,4-bis(Difluoromethoxy) Roflumilast
Catalogue No.:PA 18 15590
Molecular Formula : C14H8Cl2F4N2O3
Molecular Weight : 399.12
N-(3,5-Dichloro-4-pyridinyl)-3,4-Dihydroxybenzamide
Catalogue No.:PA 18 15600
Molecular Formula : C12H8Cl2N2O3
Molecular Weight : 299.11
3-Cyclobutyl-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
Catalogue No.:PA 18 15610
Molecular Formula : C17H14Cl2F2N2O2
Molecular Weight : 387.21
3-(But-3-en-1-yloxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
Catalogue No.:PA 18 15620
3,4-Di(cyclopropylmethoxy)-benzoic Acid
Catalogue No.:PA 18 15630
Molecular Formula : C15H18O4
Molecular Weight : 262.3
4-(Cyclopropylmethoxy)-3-(difluoromethoxy) benzoic Acid
Catalogue No.:PA 18 15640
3,4-bis(Difluoromethoxy)benzoic Acid
Catalogue No.:PA 18 15650
Molecular Formula : C9H6F4O4
Molecular Weight : 254.14
3-Cyclopropylmethoxy-4-difluoromethoxybenzoic-d4 Acid
Catalogue No.:PA STI 023650
Molecular Formula : C12H8D4F2O4
Molecular Weight : 262.24
Roflumilast-d4
Catalogue No.:PA STI 078300
Molecular Formula : C17H11D3Cl2F2N2O3
Molecular Weight : 407.23
Roflumilast-d4 N-Oxide
Catalogue No.:PA STI 078310
Molecular Formula : C17H10D4Cl2F2N2O4
Molecular Weight : 423.23
2,5-Dichloropyridin-4-amine
Catalogue No.:PA 18 15660
2,3-Dichloropyridin-4-amine
Catalogue No.:PA 18 15670
4-Amino-2,6-dichloropyridine
Catalogue No.:PA 18 15680
Catalogue No.:PA IPIPRS 81 13
Molecular Formula :
Molecular Weight : NA
3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-hydroxybenzamide
Catalogue No.:PA 18 0151000
Molecular Formula : C16H14Cl2N2O3
Molecular Weight : 353.2
N-(3-Bromo-5-chloropyridin-4-yl)-3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzamide
Catalogue No.:PA 18 0151001
Molecular Formula : C17H14BrClF2N2O3
Molecular Weight : 447.66
5-((3,5-Dichloropyridin-4-yl)carbamoyl)-2-(difluoromethoxy)phenyl dimethylcarbamate
Catalogue No.:PA 18 0151002
Molecular Formula : C16H13Cl2F2N3O4
Molecular Weight : 420.19
4-(Difluoromethoxy)-3-Hydroxybenzoic Acid
Catalogue No.:PA 18 0151003
Molecular Formula : C8H6F2O4
Molecular Weight : 204.13
Roflumilast KSM-II Bromo Compound
Catalogue No.:PA 18 0151004
Molecular Formula : C5H4BrClN2
Molecular Weight : 207.46
Roflumilast Dimer
Catalogue No.:PA 18 0151005
Molecular Formula : C29H24Cl2F4N2O6
Molecular Weight : 643.41
3-(Cyclopropylmethoxy)-4-hydroxybenzaldehyde
Catalogue No.:PA 18 0151006
Molecular Formula : C11H12O3
Molecular Weight : 192.21
3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde
Catalogue No.:PA 18 0151007
Molecular Formula : C12H12F2O3
Molecular Weight : 242.22
3-(Cyclopropylmethoxy)-4-hydroxybenzoic Acid
Catalogue No.:PA 18 0151008
Molecular Formula : C11H12O4
Molecular Weight : 208.21
N-(3,5-Dichloropyridin-4-yl)-4-(difluoromethoxy)-3-methoxybenzamide
Catalogue No.:PA 18 0151009
Molecular Formula : C14H10Cl2F2N2O3
Molecular Weight : 363.14
Roflumilast (IPRSR033)
Catalogue No.:PA IPRSR033
Molecular Formula : NA
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