Rofecoxib and its Impurities

Rofecoxib is a COX-2 selective nonsteroidal anti-inflammatory drug. It was marketed by Merck & Co. to treat osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, acute pain conditions, migraine, and dysmenorrhea. Reference standards of Rofecoxib API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.