Risdiplam and its Impurities
Risdiplam is an oral mRNA splicing modifier used in the treatment of spinal muscular atrophy (SMA). Reference standards of Risdiplam API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.

![tert-Butyl 7-(2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyri PA 18 1411000](https://www.pharmaffiliates.com/pimages/PA181411000.jpg)
tert-Butyl 7-(2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-4,7-diazaspiro[2.5]octane-4-carboxylate
tert-Butyl 7-(2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-4,7-diazaspiro[2.5]octane-4-carboxylate
Catalogue No.:PA 18 1411000
CAS :
2133298-72-1
Molecular Formula : C19H24N4O4
Molecular Weight : 372.43

![tert-Butyl 7-(4-oxo-2-(tosyloxy)-4H-pyrido[1,2-a]p PA 18 1411001](https://www.pharmaffiliates.com/pimages/PA181411001.jpg)
tert-Butyl 7-(4-oxo-2-(tosyloxy)-4H-pyrido[1,2-a]pyrimidin-7-yl)-4,7-diazaspiro[2.5]octane-4-carboxylate
tert-Butyl 7-(4-oxo-2-(tosyloxy)-4H-pyrido[1,2-a]pyrimidin-7-yl)-4,7-diazaspiro[2.5]octane-4-carboxylate
Catalogue No.:PA 18 1411001
CAS :
2133298-73-2
Molecular Formula : C26H30N4O6S
Molecular Weight : 526.61

![tert-Butyl 7-(2-(2,8-dimethylimidazo[1,2-b]pyridaz PA 18 1411002](https://www.pharmaffiliates.com/pimages/PA181411002.jpg)
tert-Butyl 7-(2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-4,7-diazaspiro[2.5]octane-4-carboxylate
tert-Butyl 7-(2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-4,7-diazaspiro[2.5]octane-4-carboxylate
Catalogue No.:PA 18 1411002
CAS :
2133298-74-3
Molecular Formula : C27H31N7O3
Molecular Weight : 501.59

![2-(2,8-Dimethylimidazo[1,2-b]pyridazin-6-yl)-7-(4- PA 18 1411004](https://www.pharmaffiliates.com/pimages/PA181411004.jpg)
2-(2,8-Dimethylimidazo[1,2-b]pyridazin-6-yl)-7-(4-hydroxy-4,7-diazaspiro[2.5]octan-7-yl)-4H-pyrido[1,2-a]pyrimidin-4-one
2-(2,8-Dimethylimidazo[1,2-b]pyridazin-6-yl)-7-(4-hydroxy-4,7-diazaspiro[2.5]octan-7-yl)-4H-pyrido[1,2-a]pyrimidin-4-one
Catalogue No.:PA 18 1411004
CAS :
2250441-24-6
Molecular Formula : C22H23N7O2
Molecular Weight : 417.47

![7-(2-(2,8-Dimethylimidazo[1,2-b]pyridazin-6-yl)-4- PA 18 1411005](https://www.pharmaffiliates.com/pimages/PA181411005.jpg)
7-(2-(2,8-Dimethylimidazo[1,2-b]pyridazin-6-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-4,7-diazaspiro[2.5]octane-4-carbaldehyde
7-(2-(2,8-Dimethylimidazo[1,2-b]pyridazin-6-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-4,7-diazaspiro[2.5]octane-4-carbaldehyde
Catalogue No.:PA 18 1411005
CAS :
NA
Molecular Formula : C23H23N7O2
Molecular Weight : 429.48

![7-(4,7-Diazaspiro[2.5]octan-7-yl)-2-(2,2',8,8'-tet PA 18 1411008](https://www.pharmaffiliates.com/pimages/PA181411008.jpg)
7-(4,7-Diazaspiro[2.5]octan-7-yl)-2-(2,2',8,8'-tetramethyl-[3,6'-biimidazo[1,2-b]pyridazin]-6-yl)-4H-pyrido[1,2-a]pyrimidin-4-one
7-(4,7-Diazaspiro[2.5]octan-7-yl)-2-(2,2',8,8'-tetramethyl-[3,6'-biimidazo[1,2-b]pyridazin]-6-yl)-4H-pyrido[1,2-a]pyrimidin-4-one
Catalogue No.:PA 18 1411008
CAS :
NA
Molecular Formula : C30H30N10O
Molecular Weight : 546.64

![2-(2,8-Dimethylimidazo[1,2-b]pyridazin-6-yl)-7-(4- PA 18 1411009](https://www.pharmaffiliates.com/pimages/PA181411009.jpg)
2-(2,8-Dimethylimidazo[1,2-b]pyridazin-6-yl)-7-(4-nitroso-4,7-diazaspiro[2.5]octan-7-yl)-4H-pyrido[1,2-a]pyrimidin-4-one
2-(2,8-Dimethylimidazo[1,2-b]pyridazin-6-yl)-7-(4-nitroso-4,7-diazaspiro[2.5]octan-7-yl)-4H-pyrido[1,2-a]pyrimidin-4-one
Catalogue No.:PA 18 1411009
CAS :
NA
Molecular Formula : C22H22N8O2
Molecular Weight : 430.47

![7-(2-(2,8-Dimethylimidazo[1,2-b]pyridazin-6-yl)-4- PA 18 1411011](https://www.pharmaffiliates.com/pimages/PA181411011.jpg)
7-(2-(2,8-Dimethylimidazo[1,2-b]pyridazin-6-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-4,7-diazaspiro[2.5]octane 7-oxide
7-(2-(2,8-Dimethylimidazo[1,2-b]pyridazin-6-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-4,7-diazaspiro[2.5]octane 7-oxide
Catalogue No.:PA 18 1411011
CAS :
NA
Molecular Formula : C22H23N7O2
Molecular Weight : 417.47

![3-Hydroxy-N-(2-((2-(8-methylimidazo[1,2-b]pyridazi PA 18 1411012](https://www.pharmaffiliates.com/pimages/PA181411012.jpg)
3-Hydroxy-N-(2-((2-(8-methylimidazo[1,2-b]pyridazin-6-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)amino)ethyl)propanamide
3-Hydroxy-N-(2-((2-(8-methylimidazo[1,2-b]pyridazin-6-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)amino)ethyl)propanamide
Catalogue No.:PA 18 1411012
CAS :
NA
Molecular Formula : C20H21N7O3
Molecular Weight : 407.43

![6-(2,8-Dimethylimidazo[1,2-b]pyridazin-6-yl)-2-(3- PA 18 1411013](https://www.pharmaffiliates.com/pimages/PA181411013.jpg)
6-(2,8-Dimethylimidazo[1,2-b]pyridazin-6-yl)-2-(3-oxo-3-(4,7-diazaspiro[2.5]octan-7-yl)prop-1-en-1-yl)pyrimidin-4(3H)-one
6-(2,8-Dimethylimidazo[1,2-b]pyridazin-6-yl)-2-(3-oxo-3-(4,7-diazaspiro[2.5]octan-7-yl)prop-1-en-1-yl)pyrimidin-4(3H)-one
Catalogue No.:PA 18 1411013
CAS :
NA
Molecular Formula : C21H23N7O2
Molecular Weight : 405.46