Ribociclib is used to treat a certain type of advanced breast cancer in postmenopausal women. Reference standards of Ribociclib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.
Ribociclib
Catalogue No.:PA 18 84000
CAS :
Molecular Formula : C23H30N8O
Molecular Weight : 434.55
Ribociclib N-Oxide
Catalogue No.:PA 18 84510
Molecular Formula : C23H30N8O2
Molecular Weight : 450.55
N-Desmethyl Ribociclib
Catalogue No.:PA 18 0841000
Molecular Formula : C22H28N8O
Molecular Weight : 420.52
2-((7-Cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-5-(piperazin-1-yl)pyridine 1-Oxide
Catalogue No.:PA 18 0841001
1-(6-((7-Cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine 1-oxide
Catalogue No.:PA 18 0841002
7-Cyclopentyl-2-((5-(4-formylpiperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841003
Molecular Formula : C24H30N8O2
Molecular Weight : 462.56
2-Chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841004
Molecular Formula : C14H17ClN4O
Molecular Weight : 292.77
7-Cyclopentyl-2-hydroxy-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841005
Molecular Formula : C14H18N4O2
Molecular Weight : 274.32
4-(4-(6-((7-Cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-4-oxobutanoic acid
Catalogue No.:PA 18 0841006
Molecular Formula : C27H34N8O4
Molecular Weight : 534.62
3-(2-Chloro-4-(cyclopentylamino)pyrimidin-5-yl)prop-2-yn-1-ol
Catalogue No.:PA 18 0841007
Molecular Formula : C12H14ClN3O
Molecular Weight : 251.71
2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbaldehyde
Catalogue No.:PA 18 0841008
Molecular Formula : C12H12ClN3O
Molecular Weight : 249.7
7-Cyclopentyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid
Catalogue No.:PA 18 0841009
Molecular Formula : C21H27N7O2
Molecular Weight : 409.49
3-(2-((3-(2-Chloro-4-(cyclopentylamino)pyrimidin-5-yl)prop-2-yn-1-yl)oxy)-4-(cyclopentylamino)pyrimidin-5-yl)prop-2-yn-1-ol
Catalogue No.:PA 18 0841010
Molecular Formula : C24H27ClN6O2
Molecular Weight : 466.97
(2-((2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methoxy)-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol
Catalogue No.:PA 18 0841011
Ribociclib-D8
Catalogue No.:PA STI 089141
Molecular Formula : C23H22D8N8O
Molecular Weight : 442.6
2-Amino-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841012
Molecular Formula : C14H19N5O
Molecular Weight : 273.34
7-Cyclopentyl-N,N-dimethyl-2-(nitroso(5-(4-nitrosopiperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841013
Molecular Formula : C23H28N10O3
Molecular Weight : 492.54
7-Cyclopentyl-N,N-dimethyl-2-(nitroso(5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841014
Molecular Formula : C23H29N9O2
Molecular Weight : 463.55
7-Cyclopentyl-N,N-dimethyl-2-((5-(4-nitrosopiperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841015
(7-Cyclopentyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol
Catalogue No.:PA 18 0841016
Molecular Formula : C21H27N7O
Molecular Weight : 393.5
7-Cyclopentyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic Acid
Catalogue No.:PA 18 0841017
Molecular Formula : C21H25N7O2
Molecular Weight : 407.48
2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic Acid
Catalogue No.:PA 18 0841018
Molecular Formula : C12H12ClN3O2
Molecular Weight : 265.7
2-((2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methoxy)-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841019
Molecular Formula : C26H30ClN7O2
Molecular Weight : 508.02
7-Cyclopentyl-N,N-dimethyl-2-((5-(4-tritylpiperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841020
Molecular Formula : C42H44N8O
Molecular Weight : 676.87
N-(5-Bromo-2-chloropyrimidin-4-yl)-N-cyclopentylnitrous amide
Catalogue No.:PA 18 0841021
Molecular Formula : C9H10BrClN4O
Molecular Weight : 305.56
7-Cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841022
Molecular Formula : C14H18N4O
Molecular Weight : 258.33
(2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methyl 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate
Catalogue No.:PA 18 0841023
Molecular Formula : C24H24Cl2N6O2
Molecular Weight : 499.4
2-Chloro-N-(2-chloro-5-(3-hydroxyprop-1-yn-1-yl)pyrimidin-4-yl)-N,7-dicyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841024
3-(2-Chloro-4-(cyclopentylamino)pyrimidin-5-yl)prop-2-yn-1-yl 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate
Catalogue No.:PA 18 0841025
tert-Butyl 4-(pyridin-3-yl)piperazine-1-carboxylate
Catalogue No.:PA 18 0841026
Molecular Formula : C14H21N3O2
Molecular Weight : 263.34
2-((5-(4-(tert-Butoxycarbonyl)piperazin-1-yl)pyridin-2-yl)amino)-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic Acid
Catalogue No.:PA 18 0841027
Molecular Formula : C26H33N7O4
Molecular Weight : 507.6
tert-Butyl 4-(6-((7-cyclopentyl-6-(hydroxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
Catalogue No.:PA 18 0841028
Molecular Formula : C26H35N7O3
Molecular Weight : 493.61
7-cyclopentyl-2-((3,5-dibromopyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841029
Molecular Formula : C19H20Br2N6O
Molecular Weight : 508.22
tert-Butyl 4-(7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)piperazine-1-carboxylate
Catalogue No.:PA 18 0841030
Molecular Formula : C23H34N6O3
Molecular Weight : 442.56
tert-Butyl 4-(6-((7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
Catalogue No.:PA 18 0841031
Molecular Formula : C28H38N8O3
Molecular Weight : 534.67
N-(2-Chloro-5-(3-hydroxyprop-1-yn-1-yl)pyrimidin-4-yl)-N-cyclopentylnitrous amide
Catalogue No.:PA 18 0841032
Molecular Formula : C12H13ClN4O2
Molecular Weight : 280.71
2-Chloro-7-cyclopentyl-N,N-bis(methyl-d3)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA STI 089706
Molecular Formula : C14H11D6ClN4O
Molecular Weight : 298.8
tert-Butyl 4-(6-((6-(bis(methyl-d3)carbamoyl)-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
Catalogue No.:PA STI 089707
Molecular Formula : C28H32D6N8O3
Molecular Weight : 540.7
tert-Butyl 4-(6-((7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)(nitroso)amino)pyridin-3-yl)piperazine-1-carboxylate
Catalogue No.:PAI 18 084001
Molecular Formula : C28H37N9O4
Molecular Weight : 563.66
tert-Butyl 4-(6-((7-cyclopentyl-6-(methylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
Catalogue No.:PAI 18 084002
Molecular Formula : C27H36N8O3
Molecular Weight : 520.64
7-Cyclopentyl-N,N-dimethyl-2-((6-nitro-5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841033
Molecular Formula : C23H29N9O3
Molecular Weight : 479.55
7-Cyclopentyl-N,N-dimethyl-2-((6-nitro-5-(4-nitrosopiperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841034
Molecular Formula : C23H28N10O4
Molecular Weight : 508.54
6-(Piperazin-1-yl)pyridin-3-amine
Catalogue No.:PA 18 0841035
Molecular Formula : C9H14N4
Molecular Weight : 178.24
7-Cyclopentyl-2-((5-(4-formylpiperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide Hydrochloride
Catalogue No.:PA 18 0841036
Molecular Formula : C24H31ClN8O2
Molecular Weight : 499.02
Ribociclib N,N-DiDesmethyl Metabolite
Catalogue No.:PA 18 0841037
Molecular Formula : C21H26N8O
Molecular Weight : 406.49
7-Cyclopentyl-2-((3,6-dihydroxy-5-(piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841038
Molecular Formula : C23H30N8O3
Molecular Weight : 466.55
7-Cyclopentyl-N-(hydroxymethyl)-N-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841039
7-Cyclopentyl-2-((3-hydroxy-5-(piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841040
7-Cyclopentyl-2-((5-((2-formamidoethyl)amino)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841041
Molecular Formula : C22H28N8O2
Molecular Weight : 436.52
Methyl 7-cyclopentyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate
Catalogue No.:PA 18 0841042
Molecular Formula : C22H27N7O2
Molecular Weight : 421.51
2-((5-((2-Aminoethyl)amino)pyridin-2-yl)amino)-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841043
Molecular Formula : C21H28N8O
Molecular Weight : 408.51
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