Ribociclib and its Impurities
Ribociclib is used to treat a certain type of advanced breast cancer in postmenopausal women. Reference standards of Ribociclib API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


2-((7-Cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-5-(piperazin-1-yl)pyridine 1-Oxide
2-((7-Cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-5-(piperazin-1-yl)pyridine 1-Oxide
Catalogue No.:PA 18 0841001
CAS :
2069953-39-3
Molecular Formula : C23H30N8O2
Molecular Weight : 450.55


1-(6-((7-Cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine 1-oxide
1-(6-((7-Cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine 1-oxide
Catalogue No.:PA 18 0841002
CAS :
2470164-21-5
Molecular Formula : C23H30N8O2
Molecular Weight : 450.55


7-Cyclopentyl-2-((5-(4-formylpiperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
7-Cyclopentyl-2-((5-(4-formylpiperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841003
CAS :
2460732-08-3
Molecular Formula : C24H30N8O2
Molecular Weight : 462.56


4-(4-(6-((7-Cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-4-oxobutanoic acid
4-(4-(6-((7-Cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-4-oxobutanoic acid
Catalogue No.:PA 18 0841006
CAS :
3060653-14-4
Molecular Formula : C27H34N8O4
Molecular Weight : 534.62


7-Cyclopentyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid
7-Cyclopentyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid
Catalogue No.:PA 18 0841009
CAS :
NA
Molecular Formula : C21H27N7O2
Molecular Weight : 409.49


3-(2-((3-(2-Chloro-4-(cyclopentylamino)pyrimidin-5-yl)prop-2-yn-1-yl)oxy)-4-(cyclopentylamino)pyrimidin-5-yl)prop-2-yn-1-ol
3-(2-((3-(2-Chloro-4-(cyclopentylamino)pyrimidin-5-yl)prop-2-yn-1-yl)oxy)-4-(cyclopentylamino)pyrimidin-5-yl)prop-2-yn-1-ol
Catalogue No.:PA 18 0841010
CAS :
NA
Molecular Formula : C24H27ClN6O2
Molecular Weight : 466.97

![(2-((2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrim PA 18 0841011](https://www.pharmaffiliates.com/pimages/PA180841011.jpg)
(2-((2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methoxy)-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol
(2-((2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methoxy)-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol
Catalogue No.:PA 18 0841011
CAS :
NA
Molecular Formula : C24H27ClN6O2
Molecular Weight : 466.97


7-Cyclopentyl-N,N-dimethyl-2-(nitroso(5-(4-nitrosopiperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
7-Cyclopentyl-N,N-dimethyl-2-(nitroso(5-(4-nitrosopiperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841013
CAS :
NA
Molecular Formula : C23H28N10O3
Molecular Weight : 492.54


7-Cyclopentyl-N,N-dimethyl-2-(nitroso(5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
7-Cyclopentyl-N,N-dimethyl-2-(nitroso(5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841014
CAS :
NA
Molecular Formula : C23H29N9O2
Molecular Weight : 463.55


7-Cyclopentyl-N,N-dimethyl-2-((5-(4-nitrosopiperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
7-Cyclopentyl-N,N-dimethyl-2-((5-(4-nitrosopiperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841015
CAS :
NA
Molecular Formula : C23H29N9O2
Molecular Weight : 463.55


(7-Cyclopentyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol
(7-Cyclopentyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol
Catalogue No.:PA 18 0841016
CAS :
NA
Molecular Formula : C21H27N7O
Molecular Weight : 393.5


7-Cyclopentyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic Acid
7-Cyclopentyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic Acid
Catalogue No.:PA 18 0841017
CAS :
2762182-61-4
Molecular Formula : C21H25N7O2
Molecular Weight : 407.48

![2-((2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimi PA 18 0841019](https://www.pharmaffiliates.com/pimages/PA180841019.jpg)
2-((2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methoxy)-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
2-((2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methoxy)-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841019
CAS :
NA
Molecular Formula : C26H30ClN7O2
Molecular Weight : 508.02


7-Cyclopentyl-N,N-dimethyl-2-((5-(4-tritylpiperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
7-Cyclopentyl-N,N-dimethyl-2-((5-(4-tritylpiperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841020
CAS :
2524428-16-6
Molecular Formula : C42H44N8O
Molecular Weight : 676.87

![(2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin PA 18 0841023](https://www.pharmaffiliates.com/pimages/PA180841023.jpg)
(2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methyl 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate
(2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methyl 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate
Catalogue No.:PA 18 0841023
CAS :
NA
Molecular Formula : C24H24Cl2N6O2
Molecular Weight : 499.4


2-Chloro-N-(2-chloro-5-(3-hydroxyprop-1-yn-1-yl)pyrimidin-4-yl)-N,7-dicyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
2-Chloro-N-(2-chloro-5-(3-hydroxyprop-1-yn-1-yl)pyrimidin-4-yl)-N,7-dicyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841024
CAS :
NA
Molecular Formula : C24H24Cl2N6O2
Molecular Weight : 499.4


3-(2-Chloro-4-(cyclopentylamino)pyrimidin-5-yl)prop-2-yn-1-yl 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate
3-(2-Chloro-4-(cyclopentylamino)pyrimidin-5-yl)prop-2-yn-1-yl 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate
Catalogue No.:PA 18 0841025
CAS :
NA
Molecular Formula : C24H24Cl2N6O2
Molecular Weight : 499.4


2-((5-(4-(tert-Butoxycarbonyl)piperazin-1-yl)pyridin-2-yl)amino)-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic Acid
2-((5-(4-(tert-Butoxycarbonyl)piperazin-1-yl)pyridin-2-yl)amino)-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic Acid
Catalogue No.:PA 18 0841027
CAS :
2250106-77-3
Molecular Formula : C26H33N7O4
Molecular Weight : 507.6


tert-Butyl 4-(6-((7-cyclopentyl-6-(hydroxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
tert-Butyl 4-(6-((7-cyclopentyl-6-(hydroxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
Catalogue No.:PA 18 0841028
CAS :
2209917-78-0
Molecular Formula : C26H35N7O3
Molecular Weight : 493.61


7-cyclopentyl-2-((3,5-dibromopyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
7-cyclopentyl-2-((3,5-dibromopyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841029
CAS :
NA
Molecular Formula : C19H20Br2N6O
Molecular Weight : 508.22


tert-Butyl 4-(7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)piperazine-1-carboxylate
tert-Butyl 4-(7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)piperazine-1-carboxylate
Catalogue No.:PA 18 0841030
CAS :
NA
Molecular Formula : C23H34N6O3
Molecular Weight : 442.56


tert-Butyl 4-(6-((7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
tert-Butyl 4-(6-((7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
Catalogue No.:PA 18 0841031
CAS :
1374639-78-7
Molecular Formula : C28H38N8O3
Molecular Weight : 534.67


tert-Butyl 4-(6-((6-(bis(methyl-d3)carbamoyl)-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
tert-Butyl 4-(6-((6-(bis(methyl-d3)carbamoyl)-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
Catalogue No.:PA STI 089707
CAS :
1328934-42-4
Molecular Formula : C28H32D6N8O3
Molecular Weight : 540.7


tert-Butyl 4-(6-((7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)(nitroso)amino)pyridin-3-yl)piperazine-1-carboxylate
tert-Butyl 4-(6-((7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)(nitroso)amino)pyridin-3-yl)piperazine-1-carboxylate
Catalogue No.:PAI 18 084001
CAS :
NA
Molecular Formula : C28H37N9O4
Molecular Weight : 563.66


tert-Butyl 4-(6-((7-cyclopentyl-6-(methylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
tert-Butyl 4-(6-((7-cyclopentyl-6-(methylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
Catalogue No.:PAI 18 084002
CAS :
NA
Molecular Formula : C27H36N8O3
Molecular Weight : 520.64


7-Cyclopentyl-N,N-dimethyl-2-((6-nitro-5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
7-Cyclopentyl-N,N-dimethyl-2-((6-nitro-5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841033
CAS :
NA
Molecular Formula : C23H29N9O3
Molecular Weight : 479.55


7-Cyclopentyl-N,N-dimethyl-2-((6-nitro-5-(4-nitrosopiperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
7-Cyclopentyl-N,N-dimethyl-2-((6-nitro-5-(4-nitrosopiperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841034
CAS :
NA
Molecular Formula : C23H28N10O4
Molecular Weight : 508.54


7-Cyclopentyl-2-((5-(4-formylpiperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide Hydrochloride
7-Cyclopentyl-2-((5-(4-formylpiperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide Hydrochloride
Catalogue No.:PA 18 0841036
CAS :
NA
Molecular Formula : C24H31ClN8O2
Molecular Weight : 499.02


7-Cyclopentyl-2-((3,6-dihydroxy-5-(piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
7-Cyclopentyl-2-((3,6-dihydroxy-5-(piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841038
CAS :
3027550-94-0
Molecular Formula : C23H30N8O3
Molecular Weight : 466.55


7-Cyclopentyl-N-(hydroxymethyl)-N-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
7-Cyclopentyl-N-(hydroxymethyl)-N-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841039
CAS :
2460734-07-8
Molecular Formula : C23H30N8O2
Molecular Weight : 450.55


7-Cyclopentyl-2-((3-hydroxy-5-(piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
7-Cyclopentyl-2-((3-hydroxy-5-(piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841040
CAS :
3027550-95-1
Molecular Formula : C23H30N8O2
Molecular Weight : 450.55


7-Cyclopentyl-2-((5-((2-formamidoethyl)amino)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
7-Cyclopentyl-2-((5-((2-formamidoethyl)amino)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841041
CAS :
3027550-96-2
Molecular Formula : C22H28N8O2
Molecular Weight : 436.52


Methyl 7-cyclopentyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate
Methyl 7-cyclopentyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate
Catalogue No.:PA 18 0841042
CAS :
3027550-97-3
Molecular Formula : C22H27N7O2
Molecular Weight : 421.51


2-((5-((2-Aminoethyl)amino)pyridin-2-yl)amino)-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
2-((5-((2-Aminoethyl)amino)pyridin-2-yl)amino)-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Catalogue No.:PA 18 0841043
CAS :
2460738-27-4
Molecular Formula : C21H28N8O
Molecular Weight : 408.51