Resmetirom and its Impurities
Resmetirom is an experimental drug for the treatment of non-alcoholic steatohepatitis. Reference standards of Resmetirom API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.


N-(3,5-Dichloro-4-((6-oxo-5-(prop-1-en-2-yl)-1,6-dihydropyridazin-3-yl)oxy)phenyl)benzamide
N-(3,5-Dichloro-4-((6-oxo-5-(prop-1-en-2-yl)-1,6-dihydropyridazin-3-yl)oxy)phenyl)benzamide
Catalogue No.:PA 18 1541002
CAS :
1581304-50-8
Molecular Formula : C20H15Cl2N3O3
Molecular Weight : 416.26


Ethyl (2-cyano-2-(2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)hydrazono)acetyl)carbamate
Ethyl (2-cyano-2-(2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)hydrazono)acetyl)carbamate
Catalogue No.:PA 18 1541005
CAS :
920509-33-7
Molecular Formula : C19H18Cl2N6O5
Molecular Weight : 481.29


(Z)-6,6'-((Triaz-1-ene-1,3-diylbis(2,6-dichloro-4,1-phenylene))bis(oxy))bis(4-isopropylpyridazin-3(2H)-one)
(Z)-6,6'-((Triaz-1-ene-1,3-diylbis(2,6-dichloro-4,1-phenylene))bis(oxy))bis(4-isopropylpyridazin-3(2H)-one)
Catalogue No.:PA 18 1541007
CAS :
NA
Molecular Formula : C26H23Cl4N7O4
Molecular Weight : 639.32


2-(3,5-Dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carboxamide
2-(3,5-Dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carboxamide
Catalogue No.:PA 18 1541008
CAS :
2542029-02-5
Molecular Formula : C17H14Cl2N6O5
Molecular Weight : 453.24


2-(3,5-Dichloro-4-((4-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile
2-(3,5-Dichloro-4-((4-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile
Catalogue No.:PA 18 1541013
CAS :
NA
Molecular Formula : C17H12Cl2N6O4
Molecular Weight : 435.22


2-(3-Chloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile
2-(3-Chloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile
Catalogue No.:PA 18 1541014
CAS :
2639977-02-7
Molecular Formula : C17H13ClN6O4
Molecular Weight : 400.78


2-(3,5-Dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione
2-(3,5-Dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione
Catalogue No.:PA 18 1541017
CAS :
920509-34-8
Molecular Formula : C16H13Cl2N5O4
Molecular Weight : 410.21


Ethyl (Z)-(2-cyano-2-(2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-2-nitrosohydrazineylidene)acetyl)carbamate
Ethyl (Z)-(2-cyano-2-(2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-2-nitrosohydrazineylidene)acetyl)carbamate
Catalogue No.:PA 18 1541018
CAS :
NA
Molecular Formula : C19H17Cl2N7O6
Molecular Weight : 510.29


2-(3,5-Dichloro-4-((5-(1-hydroxypropan-2-yl)-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile
2-(3,5-Dichloro-4-((5-(1-hydroxypropan-2-yl)-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile
Catalogue No.:PA 18 1541019
CAS :
2222607-69-2
Molecular Formula : C17H12Cl2N6O5
Molecular Weight : 451.22


2-(3,5-Dichloro-4-hydroxyphenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile
2-(3,5-Dichloro-4-hydroxyphenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile
Catalogue No.:PA 18 1541020
CAS :
125001-18-5
Molecular Formula : C10H4Cl2N4O3
Molecular Weight : 299.07