regorafenib monohydrate and its Impurities

A monohydrate salt of Regorafenib, a multikinase inhibitor used in the treatment of metastatic colorectal cancer and advanced gastrointestinal stromal tumors. Shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition.Reference standards of Regorafenib Monohydrate API,and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below.